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List of works by Yasushi Fujio

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

scientific article published on 21 December 2017

A case of hypereosinophilic syndrome presenting mid-ventricular obstruction

scientific article published on 01 March 2002

Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation

scientific article published in December 2001

Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes ⬇️

scientific article published on July 28, 1998

Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes

scientific article

Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes

scientific article published on 01 April 1998

Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo

scientific article

Adrenergic beta1 receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients.

scientific article

Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis.

scientific article

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

scientific article published on June 1999

Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization.

scientific article

Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway

scientific article

Altered Fibronectin-Dependent Cell Adhesion by PDGF Accompanies Phenotypic Modulation of Vascular Smooth Muscle Cells ⬇️

scientific article published on October 29, 1993

Angiotensin II interferes with leukemia inhibitory factor-induced STAT3 activation in cardiac myocytes

scientific article published on 01 December 1998

Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population

scientific article published on 28 July 2011

Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes

scientific article published on 17 March 2008

Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation

article

Beneficial effect of taurine treatment against doxorubicin-induced cardiotoxicity in mice

scientific article published in January 2009

Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy

scientific article published on 01 May 2001

Blockade of NKG2D/NKG2D Ligand Interaction Attenuated Cardiac Remodeling after Myocardial Infarction

scientific article published on 01 March 2019

Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway

scientific journal article

CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation

scientific article published in March 2006

Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) delta independent of the IP receptor signaling pathway

scientific article published on 12 April 2007

Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice

scientific article published on 24 August 2010

Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling

scientific article published on 08 June 2015

Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart.

scientific article published on 14 December 2001

Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies

scientific article

Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling

scientific article published on 15 July 2013

Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy

scientific article published on 07 August 2018

Caveolae-specific activation loop between CaMKII and L-type Ca2+ channel aggravates cardiac hypertrophy in α1-adrenergic stimulation

scientific article published on 30 December 2016

Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes

scientific article published on 21 October 2010

Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure

scientific article published on 01 September 2004

Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension.

scientific article published on 20 February 2009

Connective tissue growth factor induces cardiac hypertrophy through Akt signaling

scientific article published on 28 March 2008

Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes

scientific article published on 13 November 2006

Disruption of cell-cell adhesion in an inbred strain of hereditary cardiomyopathic hamster (Bio 14.6).

scientific article published in December 1995

Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.

scientific article

Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension

scientific article

Elevated calcium level induces calcium-dependent proteolysis of A-CAM (N-cadherin) in heart--analysis by detergent-treated model

scientific article published on 01 December 1995

Endothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation and atherosclerosis in apolipoprotein E knockout mice

scientific article published on 19 May 2012

Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer

scientific article published on 25 December 2018

Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells

scientific article published on August 2004

Four cases of investigational therapy with interleukin-11 against acute myocardial infarction

scientific article published on 21 January 2016

Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.

scientific article

Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy

scientific article

Glycoprotein 130 cytokine signal as a therapeutic target against cardiovascular diseases

scientific article

Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages.

scientific article published on September 2003

Hypoxic stress induces cardiotrophin-1 expression in cardiac myocytes

scientific article published on 01 October 1999

IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis

scientific article published on 27 May 2011

Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine

scientific article published on 01 May 2007

Images in cardiovascular medicine. Specific cardiomyopathy caused by multisystemic lipid storage in Jordan's anomaly

scientific article published on 01 July 2002

Immunocytochemical localization of calspectin (a non-erythroid spectrin-like protein) in thyroid glands of normal and TSH-treated rats

scientific article published in January 1987

Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes.

scientific article

Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.

scientific article published on 7 July 2009

Interleukin-27 induces the endothelial differentiation in Sca-1+ cardiac resident stem cells

scientific article

Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte

scientific article published in January 2009

Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation

scientific article published on 01 July 2000

Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells

scientific article published on 28 December 2005

MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation

scientific article

MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients

scientific article

Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study

scientific article published on 12 December 2012

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation

scientific article published on 24 June 2016

Molecular mechanisms of cardioprotection by taurine on ischemia-induced apoptosis in cultured cardiomyocytes

scientific article published on 01 January 2006

Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.

scientific article published on 17 December 2015

Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice

scientific article published on 23 January 2019

Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles.

scientific article published on March 2006

Myogenic induction of taurine transporter prevents dexamethasone-induced muscle atrophy.

scientific article published on January 2006

N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes

scientific journal article

N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes

scientific article published on 01 January 2005

No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population

scientific article published in October 2005

Novel insertional mutation in the bone morphogenetic protein receptor type II associated with sporadic primary pulmonary hypertension

scientific article published in June 2004

Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy

scientific article (publication date: February 1997)

Old-Age Onset Progressive Cardiac Contractile Dysfunction in a Patient with Polycystic Kidney Disease Harboring a PKD1 Frameshift Mutation

scientific article published on 20 November 2018

Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations

scientific article published on 19 March 2008

Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.

scientific article

Polymorphisms of CYP2D6 gene and gefitinib-induced hepatotoxicity

scientific article published on 9 May 2013

Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy

scientific article published on 03 April 2007

Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells

scientific article published on 16 March 2020

Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress.

scientific article published in October 2001

RGS2 determines the preventive effects of ARBs against vascular remodeling: toward personalized medicine of anti-hypertensive therapy with ARBs

scientific article published on 21 October 2010

RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction

scientific article published on 21 August 2017

Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress

scientific article published on 27 December 2006

Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells

scientific article published in August 1999

Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes

scientific article published on 17 April 2007

Requirement of SLD5 for early embryogenesis

scientific journal article

Responses of smooth muscle cells to platelet-derived growth factor are inhibited by herbimycin-A tyrosine kinase inhibitor.

scientific article published on August 1993

SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene

scientific article published on 11 March 2010

STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart

scientific article published in February 2005

STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo.

scientific article

Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism

scientific article published on 18 April 2011

Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma

scientific article published in July 2004

Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

scientific article

Signals through glycoprotein 130 regulate the endothelial differentiation of cardiac stem cells

scientific article published on 12 February 2009

Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes

scientific journal article

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.

scientific article published on June 1997

Sustained Activation of Guanylate Cyclase-A with TDT, a Natriuretic Peptide Derivative, Exhibits Cardiorenal Protection in Dahl Salt-Sensitive Hypertensive Rats

scientific article

TauT gene expression is regulated by TonEBP and plays a role in cell survival.

scientific article published on January 2006

Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy

scientific article published on 18 March 2008

Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome

scientific article published on 14 July 2004

Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway

scientific article published in April 2004

The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells

scientific article published on 01 November 2019

The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation

scientific article published on 02 January 2019

The cardioprotective effect of interleukin-11 against ischemia-reperfusion injury in a heart donor model.

scientific article published in January 2018

The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes

scientific article

Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.

scientific article published on 25 January 2010

Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart

scientific article published on 15 June 2012

Thorough QT/QTc Study Shows That a Novel 5-HT4 Receptor Partial Agonist Minesapride Has No Effect on QT Prolongation

scientific article published on 22 February 2020

Verification of pharmacogenomics-based algorithms to predict warfarin maintenance dose using registered data of Japanese patients

scientific article published on 09 March 2019

Warfarin dose requirement for patients with both VKORC1 3673A/A and CYP2C9*3/*3 genotypes

scientific article published on 01 November 2006

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