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List of works by Jan Brábek

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

scientific article published on 06 June 2019

A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18

scientific article published on 20 October 2020

A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

scientific article published on 07 July 2021

ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility

scientific article published on 5 June 2017

Affordable cancer care

scientific article published on 01 January 2012

Assaying protein kinase activity

scientific article published in January 2004

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics.

scientific article published on 25 August 2013

CAS promotes invasiveness of Src-transformed cells

scientific article

Cancer, checkpoint inhibitors, and confusion

scientific article published on 31 October 2017

Cell polarity signaling in the plasticity of cancer cell invasiveness

scientific article

Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression.

scientific article

Contractile forces in tumor cell migration

scientific article published on 04 March 2008

Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells

scientific article

Drugs for solid cancer: the productivity crisis prompts a rethink

scientific article published on 26 June 2013

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

scientific article published on 27 November 2021

Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes.

scientific article published on 12 February 2018

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

scientific article (publication date: May 2003)

Global impact of oncogenic Src on a phosphotyrosine proteome

scientific article

High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen

scientific article published on 27 May 2020

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

scientific article published on 26 October 2020

Interleukin-6: a molecule with complex biological impact in cancer

scientific article published on 04 September 2018

Invadopodia Structure in 3D Environment Resolved by Near-Infrared Branding Protocol Combining Correlative Confocal and FIB-SEM Microscopy ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2021

Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life ⬇️

scientific article published on 4 April 2013

Limits to Precision Cancer Medicine.

scientific article

Mechanosensors in integrin signaling: the emerging role of p130Cas

scientific article (publication date: October 2014)

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.

scientific article published on 30 July 2013

Microtubule-targeting agents and their impact on cancer treatment

scientific article published on 01 May 2020

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. ⬇️

scientific article

Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?

scientific article published on 16 November 2019

NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells.

scientific article

Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.

scientific article

Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions

scientific article published on 13 December 2018

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

scientific article published on 29 April 2015

Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration

scientific article published in 2022

Pragmatic medicine in solid cancer: a translational alternative to precision medicine

scientific article

Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion

scientific article published in Scientific Reports

RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment

scientific article published on 2 October 2018

ROCK inhibitors as emerging therapeutic candidates for sarcomas

scientific article published on March 2010

Regulation and localization of CAS substrate domain tyrosine phosphorylation

scientific article published in May 2004

Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications

scientific article published on 01 June 2020

SH3 domain tyrosine phosphorylation--sites, role and evolution.

scientific article published on 15 May 2012

Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness

scientific article published on 21 April 2016

Solid cancer: the new tumour spread endpoint opens novel opportunities

scientific article published on 20 August 2019

Src kinase: key effector in mechanosignalling

scientific article published on 21 December 2020

Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background

scientific article published in February 2009

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners.

scientific article published on 14 August 2017

Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells

scientific article published on 28 August 2020

The SH3 domain of Src can downregulate its kinase activity in the absence of the SH2 domain-pY527 interaction.

scientific article

The fission yeast ortholog of the coregulator SKIP interacts with the small subunit of U2AF.

scientific article published in June 2001

The interaction of p130Cas with PKN3 promotes malignant growth

The interaction of p130Cas with PKN3 promotes malignant growth

scientific article published on 03 December 2018

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells.

scientific article published on 26 August 2009

The role of focal adhesion anchoring domains of CAS in mechanotransduction

scientific article published on 13 April 2017

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.

scientific article published on 07 September 2010

The structure of invadopodia in a complex 3D environment.

scientific article published on September 2010

Translation in solid cancer: are size-based response criteria an anachronism?

scientific article

Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness

scientific article published on 21 September 2011

Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces

scientific article published on 01 September 2008

Vimentin Intermediate Filaments as Potential Target for Cancer Treatment

scientific article published on 11 January 2020

Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans

scientific article published on 24 April 2015

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