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List of works by Douglas V Laurents

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

scientific article published on 15 January 2014

(1)H, (13)C and (15)N resonance assignments of the Onconase FL-G zymogen

scientific article published on 4 March 2012

3D Domain Swapping Provides a Minor Alternative Refolding Pathway for Ribonuclease A

scientific article published on 01 May 2011

A new method for determining the heat capacity change for protein folding

scientific article published on 01 March 1989

A pulse-chase-competition experiment to determine if a folding intermediate is on or off-pathway: application to ribonuclease A

article

Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization.

scientific article published on 19 November 2004

An Arg-rich putative prebiotic protein is as stable as its Lys-rich variant

scientific article published on 26 September 2012

Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.

scientific article published on 16 July 2009

Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.

scientific article

Characterization of the unfolding pathway of hen egg white lysozyme

scientific article published in February 1997

Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides.

scientific article published in July 2005

Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).

scientific article published in January 2003

Combining Classical MD and QM calculations to elucidate complex system nucleation: a twisted, three-stranded, parallel β-sheet seeds amyloid fibril conception.

scientific article

Common features at the start of the neurodegeneration cascade

scientific article

Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly

scientific article published on 27 October 2011

Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers

scientific article published on 19 November 2010

Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A.

scientific article

Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease A.

scientific article published on 11 January 2008

Different protein sequences can give rise to highly similar folds through different stabilizing interactions.

scientific article published on November 1994

Dimerization and Folding Processes ofTreponemadenticolaCystalysin: The Role of Pyridoxal 5‘-Phosphate†

scientific article published on 01 November 2006

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities

scientific article

Folding Kinetics of Phage 434 Cro Protein†

scientific article published on 01 November 2000

Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli.

scientific article published on August 2005

Formation, Structure, and Dissociation of the Ribonuclease S Three-dimensional Domain-swapped Dimer

scientific article published in Journal of Biological Chemistry

Gemini surfactants affect the structure, stability, and activity of ribonuclease Sa.

scientific article published on 26 August 2014

Getting specificity from simplicity in putative proteins from the prebiotic Earth

scientific article

Glycosylation and specific deamidation of ribonuclease B affect the formation of three-dimensional domain-swapped oligomers.

scientific article

Helix-Stabilizing Nonpolar Interactions between Tyrosine and Leucine in Aqueous and TFE Solutions: 2D-1H NMR and CD Studies in Alanine-Lysine Peptides†

scientific article published on 01 December 1998

Holo- and apo-cystalysin from Treponema denticola: two different conformations

scientific article published on 15 September 2006

Increase of RNase AN-terminus Polarity orC-terminus Apolarity Changes the Two Domains' Propensity To Swap and Form the Two Dimeric Conformers of the Protein†

scientific article published on 01 September 2006

Interaction of PiB-derivative metal complexes with beta-amyloid peptides: selective recognition of the aggregated forms

scientific article published on 25 February 2015

Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8.

scientific article

Interactions of gemini surfactants with two model proteins: NMR, CD, and fluorescence spectroscopies

article

Kinetic analysis provides insight into the mechanism of ribonuclease A oligomer formation

scientific article

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.

scientific article published on 26 January 2016

NMR spectroscopy reveals a preferred conformation with a defined hydrophobic cluster for polyglutamine binding peptide 1.

scientific article published on 5 July 2014

NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping.

scientific article

NMR structural determinants of eosinophil cationic protein binding to membrane and heparin mimetics

scientific article

Nucleotide-induced folding of cell division protein FtsZ from Staphylococcus aureus

scientific article published on 29 January 2020

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

scientific article published on 31 May 2017

Preparation of Ribonuclease S Domain-Swapped Dimers Conjugated with DNA and PNA: Modulating the Activity of Ribonucleases

scientific article published on 29 December 2007

Pressure-jump-induced kinetics reveals a hydration dependent folding/unfolding mechanism of ribonuclease A

scientific article published on 23 June 2006

Protein Folding: Matching Theory and Experiment ⬇️

scientific article published on July 1, 1998

Purification of recombinant ribonuclease T1 expressed in Escherichia coli.

scientific article published on March 1990

Putative one-pot prebiotic polypeptides with ribonucleolytic activity

scientific article published in May 2010

Salt anions promote the conversion of HypF-N into amyloid-like oligomers and modulate the structure of the oligomers and the monomeric precursor state

scientific article published on 3 October 2012

Sequential assignment and solution secondary structure of doubly labelled ribonuclease Sa

scientific article published on 01 May 1999

Some biological actions of PEG-conjugated RNase A oligomers.

scientific article published on January 2006

Structural and functional relationships of natural and artificial dimeric bovine ribonucleases: new scaffolds for potential antitumor drugs

scientific article published on 07 October 2013

Structural similarity of DNA-binding domains of bacteriophage repressors and the globin core.

scientific article published in March 1993

Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation

scientific article published on 22 October 2020

Structure of a simplified β-hairpin and its ATP complex.

scientific article published on 27 June 2013

Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei

scientific article

Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases.

scientific article published in January 2003

Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments

article

The Singular NMR Fingerprint of a Polyproline II Helical Bundle

scientific article published on 29 November 2018

The TDP-43 N-terminal domain structure at high resolution

scientific article

The structural determinants that lead to the formation of particular oligomeric structures in the pancreatic-type ribonuclease family.

scientific article published on August 2008

Thermal stability and enzymatic activity of RNase A in the presence of cationic gemini surfactants

scientific article published on 24 January 2012

Thermodynamic Analysis of the Structural Stability of Phage 434 Cro Protein†

article

Three-dimensional domain-swapped oligomers of ribonuclease A: identification of a fifth tetramer, pentamers and hexamers, and detection of trace heptameric, octameric and nonameric species

scientific article published on 8 November 2005

Towards tricking a pathogen's protease into fighting infection: the 3D structure of a stable circularly permuted onconase variant cleavedby HIV-1 protease

scientific article

Urea denaturation of barnase: pH dependence and characterization of the unfolded state

scientific article published on 01 March 1992

pH dependence of the urea and guanidine hydrochloride denaturation of ribonuclease A and ribonuclease T1.

scientific article

pH-Dependent Conformational Stability of the Ribotoxin α-Sarcin and Four Active Site Charge Substitution Variants†

scientific article published on 01 November 2006

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