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List of works by Stephen Dewhurst

9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity

scientific article (publication date: 2012)

9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles

scientific article

A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus

scientific article published on 31 January 2020

A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy.

scientific article published on 16 December 2015

A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells.

scientific article published on May 2003

A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda

scientific article

Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure

scientific article

Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal

scientific journal article

Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons

scientific journal article

Activation of nuclear factor kB in brains from children with HIV-I encephalitis

article

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells

scientific article

Adenovirus type 7 penton purification of soluble pentamers from Escherichia coli and development of an integrin-dependent gene delivery system

scientific article published in October 2000

Advances in HIV microbicide development

scientific article

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy

scientific article

Amplicons as vaccine vectors

scientific article published on June 2006

Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection

scientific article

Anti-idiotypic monobodies derived from a fibronectin scaffold

scientific article

Antibodies to HTLV-III/LAV in Venezuelan patients with acute malarial infections.

scientific article

Antibodies to acquired immune deficiency syndrome (AIDS)-associated virus (HTLV-III/LAV) in Venezuelan populations.

scientific article published on January 1986

Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14.

scientific article published in November 1996

Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex

scientific article

Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex

scientific article

Building community for deaf scientists.

scientific article published in January 2017

CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.

scientific article

CTSA-IP: a solution to identifying and aggregating intellectual property across the NIH Clinical Translational Science Award (CTSA) consortium of biomedical research institutes

scientific article

Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming

article

Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy

scientific article published on March 1, 1995

Cellular mono(ADP-ribosyl) transferase inhibits protein synthesis.

scientific article published on June 1991

Characteristics and Acquisition of Human Herpesvirus (HHV)–7 Infections in Relation to Infection with HHV‐6

scientific article published on 06 March 2006

Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity

scientific article

Classification of HHV-6A and HHV-6B as distinct viruses.

scientific article published on 6 November 2013

Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors

scientific article

Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7).

scientific article published in October 2004

Dazed and confused by HHV-6

scientific article published on 01 May 2011

Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env.

scientific article

Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence.

scientific article published on 21 February 2012

Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine

scientific article

Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images.

scientific article published on 18 January 2013

Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

scientific article

Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway

scientific journal article

Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.

scientific article published on January 2017

Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag.

scientific article published on 15 November 2006

Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frame

scientific article published in August 2003

Endogenous tumor necrosis factor-alpha contributes to lymphoproliferation induced by simian immunodeficiency virus variant, SIVsmmPBj14.

scientific article published in August 1998

Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin

scientific article

Enhanced transduction of dendritic cells by FcgammaRI-targeted adenovirus vectors.

scientific article published on December 2007

Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides

scientific article

Establishment of human glial cell lines chronically infected with the human immunodeficiency virus.

scientific article

Expression of glial fibrillary acidic protein in human glioma cell lines as detected by molecular hybridization.

scientific article published in January 1987

Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses

scientific article

Expression of pro‐ and anti‐apoptosis gene products in brains from paediatric patients with HIV‐1 encephalitis ⬇️

scientific article published on June 1, 1997

Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells

scientific article

Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells

scientific article

Fluorescence detection of cationic amyloid fibrils in human semen.

scientific article published on 8 July 2013

Functional Interplay Between Nuclear Factor-κB and c-Jun Integrated by Coactivator p300 Determines the Survival of Nerve Growth Factor-Dependent PC12 Cells

scientific article published on 01 February 2000

Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia.

scientific article published in March 2007

Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.

scientific article

Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.

scientific article published on 16 December 2006

HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells

scientific article published on 27 April 2017

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

scientific article

HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism

scientific article

HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells

scientific article

HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity

scientific article

HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis.

scientific article

HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1

scientific article

HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime

scientific article

Human Herpesvirus 6

scientific article published on 10 August 2001

Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against [...]

scientific article

Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children.

scientific article published in October 2004

Human herpesvirus-6 infection in children. A prospective study of complications and reactivation

scientific article (publication date: 18 August 1994)

Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.

scientific article published on 20 December 2006

Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons

scientific article published in May 2006

Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo

scientific article published on 22 January 2007

Hydrophobic Nanoparticles Reduce the β-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity.

scientific article published on 16 February 2017

Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7.

scientific article published on May 2000

Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands.

scientific article published in May 2004

Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14.

scientific article published in December 1998

Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging.

scientific article

Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development

scientific article

Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation.

scientific article published in July 2006

Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles.

scientific article published on 2 February 2015

Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS.

scientific article

Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders

scientific article

Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.

scientific article published on April 2009

Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption.

scientific article published in September 1998

MLK3 regulates fMLP-stimulated neutrophil motility

scientific article published on 3 January 2014

Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase

scientific article

Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences

scientific article

Mechanistic Understanding of an Altered Fidelity Simian Immunodeficiency Virus Reverse Transcriptase Mutation, V148I, Identified in a Pig-tailed Macaque ⬇️

scientific article published on May 8, 2003

Methamphetamine causes sustained depression in cerebral blood flow

scientific article

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells

scientific article

Molecular clones from a non-acutely pathogenic derivative of SIVsmmPBj14: characterization and comparison to acutely pathogenic clones

scientific article published on June 1, 1992

Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes.

scientific article published on July 2003

Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo

scientific article published on 19 March 2013

Nanoparticles decorated with viral antigens are more immunogenic at low surface density

scientific article

Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission

scientific article published on 15 August 2017

Nef gene evolution from a single transmitted strain in acute SIV infection

scientific article published on 08 June 2009

Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments

scientific article published on 23 November 2015

Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system

scientific article (publication date: February 2000)

Neuropathogenesis of AIDS.

scientific article published on January 1996

Neuroprotective activities of CEP-1347 in models of neuroAIDS.

scientific article

Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis.

scientific article published on September 2005

Oligovalent amyloid-binding agents reduce SEVI-mediated enhancement of HIV-1 infection.

scientific article published on 3 January 2012

Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death

scientific article

PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells

scientific article

Pathogenesis of simian immunodeficiency virus infection.

scientific article

Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.

scientific article published on 05 June 2013

Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model

scientific article

Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro

scientific article published on 27 November 2021

Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infants

scientific article published on September 1, 1992

Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis.

scientific article published in July 1998

Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures.

scientific article published on June 2012

Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia

scientific article published in March 1999

Proteasome inhibitors enhance bacteriophage lambda (lambda) mediated gene transfer in mammalian cells.

scientific article

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation.

scientific article

Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase

scientific article published on October 2010

Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier.

scientific article

SIVsmmPBj14 induces expression of a mucosal integrin on macaque lymphocytes

scientific article published in January 1996

Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase

scientific article

Semen-Derived Enhancer of Viral Infection (SEVI) Binds Bacteria, Enhances Bacterial Phagocytosis by Macrophages, and Can Protect against Vaginal Infection by a Sexually Transmitted Bacterial Pathogen ⬇️

scientific article published on March 18, 2013

Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide

scientific article published on 21 February 2012

Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors

scientific article published in February 2007

Stringent structural and sequence requirements of the human herpesvirus 6B lytic-phase origin of DNA replication

scientific article published on 01 May 1997

Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV).

scientific article published on March 1987

Telomeric sequences from human herpesvirus 6 do not mediate nuclear retention of episomal DNA in human cells.

scientific article published on January 1998

The Tyrosine-17 Residue of Nef in SIVsmmPBj14 Is Required for Acute Pathogenesis and Contributes to Replication in Macrophages

scientific article published on 01 May 1998

The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit

scientific article

The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro

scientific article

The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate

scientific article

The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.

scientific article

Theoretical model of critical issues in informed consent in HIV vaccine trials

scientific article

Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5 ⬇️

scientific article published on November 20, 2012

Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors

scientific article

Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia

scientific article published in June 1996

Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA

scientific article published on May 1995

Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?

scientific article

U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture

scientific article published on November 1998

Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies

scientific article

Valproic acid enhances gene expression from viral gene transfer vectors

scientific article published on 16 January 2005

Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment

scientific article

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