List of works - Gisele Zapata-Sudo

A novel Ca2+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension

scientific article

Activation of GPER ameliorates experimental pulmonary hypertension in male rats

scientific article published on 8 November 2016

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats

scientific article published on 09 May 2016

Activity of Cecropia lyratiloba extract on contractility of cardiac and smooth muscles in Wistar rats

scientific article published in January 2006

Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension

scientific article published on 4 December 2017

Adipose-derived stem-cell treatment of skeletal muscle injury.

scientific article published in April 2012

Anesthetic profile of a non-lipid propofol nanoemulsion

scientific article published on September 2010

Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats

scientific article published in July 2013

Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor

scientific article published on 7 July 2012

Antinociception induced by a novel α2A adrenergic receptor agonist in rodents acute and chronic pain models

scientific article published on 18 September 2017

Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Açaí) in a rodent model of acute and neuropathic pain

scientific article published on 2 July 2015

Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model

scientific article published on 19 June 2012

Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR.

scientific article

Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis

scientific article

Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats

scientific article published on 17 November 2010

Comparative effects of tramadol on vascular reactivity in normotensive and spontaneously hypertensive rats

scientific article published in June 2008

Could a high-fat diet rich in unsaturated fatty acids impair the cardiovascular system? ⬇️

scientific article published on December 1, 2010

Dantrolene sodium can increase or attenuate activity of skeletal muscle ryanodine receptor calcium release channel. Clinical implications

scientific article published in June 1996

Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile

scientific article

Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs

scientific article published in November 2005

Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat.

scientific article published on 22 March 2016

Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle

scientific article

Effects of moderate and deep hypothermia on Ca2+ signaling in rat ventricular myocytes

scientific article

FKBP12 depletion leads to loss of sarcoplasmic reticulum Ca(2+) stores in rat vas deferens.

scientific article published in February 2009

Halothane cooling contractures of skinned mammalian muscle fibers

scientific article published in November 1990

Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine

scientific article published in January 2010

Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice

scientific article published on 19 March 2013

In vitro and in vivo vasodilator activity of racemic tramadol and its enantiomers in Wistar rats

scientific article published on 20 December 2005

In-vitro vasodilatory activity of the hexanic extract of leaves and stems from Piper truncatum Vell. in rats

scientific article

Inflammatory and mitochondrial gene expression data in GPER-deficient cardiomyocytes from male and female mice

scientific article

Inibição da corrente de cálcio tipo L por tramadol e enantiômeros em miócitos cardíacos de ratos

scientific article published on 30 September 2011

Interaction of morphine with a new alpha2-adrenoceptor agonist in mice

scientific article published on 22 October 2009

Intravenous administration of azumolene to reverse malignant hyperthermia in swine

scientific article published on 24 June 2010

LASSBio-294, A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca²(+) influx into sarcoplasmic reticulum after myocardial infarction

scientific article published on 29 July 2010

Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae).

scientific article published on October 2016

Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats

scientific article published on 12 March 2016

Microwave-assisted synthesis and structure-activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives

scientific article published on 16 November 2009

Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats

scientific article

Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats

article

Na(+)-ATPase in spontaneous hypertensive rats: possible AT(1) receptor target in the development of hypertension

scientific article published on 26 June 2009

New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis

scientific article published on 17 August 2020

Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study.

scientific article published in May 2015

Novel agonist of α 4 β 2 * neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain

scientific article published on 30 October 2018

Novel orally active analgesic and anti-inflammatory cyclohexyl-N-acylhydrazone derivatives.

scientific article published on 12 February 2015

Novel skeletal muscle ryanodine receptor mutation in a large Brazilian family with malignant hyperthermia

scientific article

Oral treatment with Euterpe oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction

scientific article

Pharmacological activity of novel 2-hydroxyacetophenone isatin derivatives on cardiac and vascular smooth muscles in rats

scientific article published in January 2011

Pharmacological characterization of (3-thienylidene)-3,4-methylenedioxybenzoylhydrazide: a novel muscarinic agonist with antihypertensive profile

scientific article published on 3 December 2009

Rats undernourished in utero have altered Ca2+ signaling and reduced fertility in adulthood

scientific article

Regulation of intracellular calcium by bupivacaine isomers in cardiac myocytes from Wistar rats

scientific article published in March 2006

Relaxation of tracheal smooth muscle independent on functional epithelium cells induced by lidocaine, bupivacaine and isomers in rats

scientific article published on 19 March 2009

Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors.

scientific article published on 24 July 2009

Sedative and anticonvulsant activities of methanol extract of Dorstenia arifolia in mice

scientific article published on 20 March 2010

Sedative-hypnotic profile of novel isatin ketals

scientific article published on 22 February 2007

Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives

scientific article published on 08 May 2009

Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats

scientific article published on 20 April 2018

Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues

scientific article published in May 2005

Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents

scientific article published on 09 September 2016

The influence of age on bupivacaine cardiotoxicity

scientific article published on 8 February 2011

The lignan eudesmin extracted from Piper truncatum induced vascular relaxation via activation of endothelial histamine H1 receptors

scientific article published on 5 February 2009

The synergistic interaction between morphine and maprotiline after intrathecal injection in rats

scientific article published in October 2009

Thienylhydrazone derivative increases sarcoplasmic reticulum Ca2+ release in mammalian skeletal muscle

scientific article published on 01 May 2003

Toxicological evaluation of azumolene after repeated intraperitoneal administration in rats

scientific article published on 3 November 2009

Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation.

scientific article

Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil

scientific article published on 14 May 2010

Vasodilator activity of the essential oil from aerial parts of Pectis brevipedunculata and its main constituent citral in rat aorta.

scientific article published on 7 March 2013

Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca²⁺ channels

scientific article published on 7 September 2012

Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound

scientific article published on 09 November 2011

Vasodilatory activity of novel carbamate derivatives of isatin

scientific article published on 25 May 2008

List of works by Gisele Zapata-Sudo

A novel Ca2+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension

Activation of GPER ameliorates experimental pulmonary hypertension in male rats

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats

Activity of Cecropia lyratiloba extract on contractility of cardiac and smooth muscles in Wistar rats

Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension

Adipose-derived stem-cell treatment of skeletal muscle injury.

Anesthetic profile of a non-lipid propofol nanoemulsion

Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats

Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor

Antinociception induced by a novel α2A adrenergic receptor agonist in rodents acute and chronic pain models

Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Açaí) in a rodent model of acute and neuropathic pain

Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model

Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR.

Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis

Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats

Comparative effects of tramadol on vascular reactivity in normotensive and spontaneously hypertensive rats

Could a high-fat diet rich in unsaturated fatty acids impair the cardiovascular system? ⬇️

Dantrolene sodium can increase or attenuate activity of skeletal muscle ryanodine receptor calcium release channel. Clinical implications

Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile

Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs

Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat.

Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle

Effects of moderate and deep hypothermia on Ca2+ signaling in rat ventricular myocytes

FKBP12 depletion leads to loss of sarcoplasmic reticulum Ca(2+) stores in rat vas deferens.

Halothane cooling contractures of skinned mammalian muscle fibers

Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine

Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice

In vitro and in vivo vasodilator activity of racemic tramadol and its enantiomers in Wistar rats

In-vitro vasodilatory activity of the hexanic extract of leaves and stems from Piper truncatum Vell. in rats

Inflammatory and mitochondrial gene expression data in GPER-deficient cardiomyocytes from male and female mice

Inibição da corrente de cálcio tipo L por tramadol e enantiômeros em miócitos cardíacos de ratos

Interaction of morphine with a new alpha2-adrenoceptor agonist in mice

Intravenous administration of azumolene to reverse malignant hyperthermia in swine

LASSBio-294, A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca²(+) influx into sarcoplasmic reticulum after myocardial infarction

Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae).

Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats

Microwave-assisted synthesis and structure-activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives

Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats

Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats

Na(+)-ATPase in spontaneous hypertensive rats: possible AT(1) receptor target in the development of hypertension

New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis

Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study.

Novel agonist of α 4 β 2 * neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain

Novel orally active analgesic and anti-inflammatory cyclohexyl-N-acylhydrazone derivatives.

Novel skeletal muscle ryanodine receptor mutation in a large Brazilian family with malignant hyperthermia

Oral treatment with Euterpe oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction

Pharmacological activity of novel 2-hydroxyacetophenone isatin derivatives on cardiac and vascular smooth muscles in rats

Pharmacological characterization of (3-thienylidene)-3,4-methylenedioxybenzoylhydrazide: a novel muscarinic agonist with antihypertensive profile

Rats undernourished in utero have altered Ca2+ signaling and reduced fertility in adulthood

Regulation of intracellular calcium by bupivacaine isomers in cardiac myocytes from Wistar rats

Relaxation of tracheal smooth muscle independent on functional epithelium cells induced by lidocaine, bupivacaine and isomers in rats

Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors.

Sedative and anticonvulsant activities of methanol extract of Dorstenia arifolia in mice

Sedative-hypnotic profile of novel isatin ketals

Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives

Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats

Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues

Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents

The influence of age on bupivacaine cardiotoxicity

The lignan eudesmin extracted from Piper truncatum induced vascular relaxation via activation of endothelial histamine H1 receptors

The synergistic interaction between morphine and maprotiline after intrathecal injection in rats

Thienylhydrazone derivative increases sarcoplasmic reticulum Ca2+ release in mammalian skeletal muscle

Toxicological evaluation of azumolene after repeated intraperitoneal administration in rats

Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation.

Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil

Vasodilator activity of the essential oil from aerial parts of Pectis brevipedunculata and its main constituent citral in rat aorta.

Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca²⁺ channels

Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound

Vasodilatory activity of novel carbamate derivatives of isatin