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List of works by Martin Koestenberger

"Additional but not identical information on systolic right ventricular function using the tricuspid annular peak systolic velocity or tricuspid annular plane systolic excursion in both adults and children".

scientific article published in January 2013

2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT

scientific article published on 21 June 2019

A Retrospective Analysis of the Clinical Effectiveness of Supraclavicular, Ultrasound-guided Brachiocephalic Vein Cannulations in Preterm Infants.

scientific article published on 13 September 2017

A left-to-right shunt via the ductus arteriosus is associated with increased regional cerebral oxygen saturation during neonatal transition

scientific article published on 22 February 2013

A novel echocardiographic approach indicates disease severity in pediatric pulmonary hypertension

scientific article published on 17 April 2020

A pediatric perspective on the TAPSE/PASP ratio in pulmonary arterial hypertension

scientific article published on 01 March 2019

Ability of the tricuspid annular peak systolic velocity (S') to detect systolic right ventricular impairment after congenital heart defect surgery in pediatric patients

scientific article published on 21 February 2013

Abnormalities in echocardiographic indices of right- and left-ventricular systolic function in pediatric pulmonary artery hypertension.

scientific article published on 9 February 2014

Accurate Estimation of Elevated Pulmonary Vascular Resistance Using Sophisticated Echocardiographic Variables in Children with Cardiomyopathy

scientific article published on 25 May 2018

Additive effects of anticoagulants: recombinant human activated protein C and heparin or melagatran, in tissue factor-activated umbilical-cord plasma

scientific article published on 01 July 2005

Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma

scientific article published on 01 March 2002

An evaluation of the procoagulant action of recombinant activated factor VII in cord whole blood versus adult whole blood using thromboelastography

scientific article published on 01 November 2005

Anomalous connection of the inferior vena cava to the left atrium: a surgical error in closing an atrial septal defect

scientific article published on 28 December 2007

Anticoagulant action of low, physiologic, and high albumin levels in whole blood

scientific article published on 11 August 2017

Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination

scientific article published in January 2005

Anticoagulant action of melagatran: a comparison between neonates and adults using calibrated automated thrombography (CAT)

scientific article published on 19 September 2006

Aortopulmonary window, critical pulmonary stenosis, and hypoplastic right ventricle

scientific article published on 02 May 2008

Assessment of Myocardial Function in Children before and after Autologous Peripheral Blood Stem Cell Transplantation: The Effect of Autologous Peripheral Blood Stem Cell Transplantation on Biventricular Systolic Function.

scientific article published in July 2016

Bed rest does not induce hypercoagulability

scientific article published on 01 January 2015

Biventricular repair despite hypoplastic tricuspid valve and right ventricle

scientific article published on 01 April 2009

Biventricular systolic function impairment in children after tetralogy of fallot repair

scientific article published on 04 February 2015

Borderline hypotension: how does it influence cerebral regional tissue oxygenation in preterm infants?

scientific article published on 18 September 2015

Cardiac MRI assessment of right ventricular function: impact of right bundle branch block on the evaluation of cardiac performance parameters.

scientific article published on 2 July 2015

Cardiac catheterization: haemostatic changes in pediatric versus adult patients

scientific article published on 01 October 2011

Cardiac magnetic resonance imaging and echocardiography in pediatric pulmonary arterial hypertension

scientific article published on March 2014

Cerebral tissue oxygen saturation is associated with N-terminal probrain natriuretic peptide in preterm infants on their first day of life

scientific article published on 16 November 2014

Changes of locoregional skin temperature in neonates undergoing laser needle acupuncture at the acupuncture point large intestine 4

scientific article

Clot strength: a comparison between cord and adult blood by means of thrombelastometry

scientific article published on 01 March 2008

Coagulation Changes during Central Hypovolemia across Seasons

scientific article published on 27 October 2020

Coagulation Changes during Presyncope and Recovery

scientific article published on August 2, 2012

Coagulation changes induced by lower-body negative pressure in men and women

scientific article published on 14 February 2019

Collagen/endogenous thrombin-induced platelet aggregation in cord versus adult whole blood

scientific article

Collagen/endogenous thrombin-induced platelet aggregation in whole blood samples

scientific article published on 01 September 2007

Combined effects of eptifibatide and anticoagulants: differences between LMWH and UH or rH in thrombin generation inhibition but not in platelet aggregation inhibition.

scientific article published in December 2002

Combined effects of melagatran and eptifibatide on platelet aggregation inhibition but not thrombin generation inhibition

scientific article published in March 2004

Commentary: Echocardiographic Evaluation of Pulmonary Pressures and Right Ventricular Function after Pediatric Cardiac Surgery: A Simple Approach for the Intensivist.

scientific article published on 8 May 2018

Continuous renal replacement therapy with Prismaflex HF20 disposable set in children from 4 to 15 kg

scientific article published on 01 September 2011

Correlation of pulmonary regurgitation fraction and right ventricular ejection fraction in patients with tetralogy of Fallot

scientific article published on 24 March 2011

Decreased tricuspid annular peak systolic velocity (S') and N-terminal B-type natriuretic pro-peptide values in children after tetralogy of Fallot repair

scientific article published on 01 January 2015

Diagnostic Accuracy of Echocardiography in ALCAPA: Is It Always Correct to Rely Only on Echocardiography? The Issue of False Negatives

scientific article published on 19 October 2017

Diagnostics in Children and Adolescents with Suspected or Confirmed Pulmonary Hypertension

scientific article published on 26 October 2016

Different indications for transcatheter and surgical patent ductus arteriosus closure in preterm infants less than 2kg

scientific article published on 01 September 2018

Drotrecogin alfa (activated, Xigris) in combination with heparin or melagatran: an in vitro investigation.

scientific article

Drotrecogin alfa activated (recombinant human activated protein C) in combination with heparin or melagatran: effects on prothrombin time and activated partial thromboplastin time

scientific article published in October 2004

Early impairment of systolic right ventricular function parameters in patients with primary systemic amyloidosis

scientific article published on 02 October 2012

Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension

scientific article

Echocardiographic estimation of elevated right ventricular afterload in preterm infants at risk for pulmonary hypertension: next steps

scientific article published on 23 August 2018

Echocardiography for the Assessment of Pulmonary Hypertension and Congenital Heart Disease in the Young

scientific article published on 31 December 2020

Effects of Exercise and Nutrition on the Coagulation System During Bedrest Immobilization.

scientific article

Effects of a single bout of walking exercise on blood coagulation parameters in obese women

scientific article published on 25 April 2013

Effects of beta2-glycoprotein-I on platelet aggregation in cord versus adult whole blood

scientific article published on 01 February 2007

Effects of melagatran on activated partial thromboplastin time and on ecarin clotting time in cord versus adult plasma.

scientific article published on November 2006

Effects of nadroparin, enoxaparin, and unfractionated heparin on endogenous factor Xa and IIa formation and on thrombelastometry profiles

scientific article published in January 2009

Effects of nadroparin, enoxaparin, and unfractionated heparin on endogenous formation of factor Xa and IIa and on thrombelastometry profiles in cord versus adult blood

scientific article published on 09 December 2010

Effects of the glycoprotein IIb/IIIa receptor antagonist c7E3 Fab and anticoagulants on platelet aggregation and thrombin potential under high coagulant challenge in vitro

scientific article published on 01 July 2000

Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells.

scientific article published on 25 January 2018

Executive summary. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK.

scientific article published on May 2016

Femoral vein access by contrast-guided puncture in cardiac catheterization in patients under one year of age

scientific article published on 14 April 2009

First clinical experience with the Kora pacemaker system in congenital complete heart block in newborn infants

scientific article published on 24 April 2019

First experience with the Prismaflex HF 20 set in four infants

scientific article published on 01 January 2011

Future Applications of the Selective Prostacyclin (IP) Receptor Agonist Selexipag in Pediatric Pulmonary Hypertension

scientific article published on 7 August 2017

Gadolinium-free MR in coarctation-can contrast-enhanced MR angiography be replaced?

scientific article published on 15 January 2016

Hemodiafiltration in infants with complications during peritoneal dialysis

scientific article published on 16 March 2012

Heparinase-modified thrombelastometry: inactivation of heparin in plasma samples.

scientific article published in January 2010

High availability of intravascular tissue factor in neonates.

scientific article

High titre inhibitor after continuous factor VIII administration for surgery in a young infant

scientific article published in March 2000

How does the time of diagnosis affect the course of disease in children with kawasaki syndrome? A retrospective analysis at one center

scientific article published on 4 March 2009

How should I treat an adult with unoperated complex cyanotic heart disease with severe pulmonary stenosis?

scientific article published on 01 June 2014

Impairment of tricuspid annular plane systolic excursion and tricuspid annular peak systolic velocity after arterial switch operation

scientific article published on 02 January 2014

Impairment of tricuspid annular plane systolic excursion and tricuspid annular peak systolic velocity after ventricular septal defect correction

scientific article published on 12 May 2013

Impairment of tricuspid annular plane systolic excursion and tricuspid annular peak systolic velocity in patients with pectus excavatum

scientific article published on 02 July 2013

Importance of quantifiable right heart systolic function evaluation using tricuspid annular plane systolic excursion (TAPSE) in fetuses and neonates

scientific article published in September 2013

Improvement of systolic right ventricular function in overweight children participating in a three month football training determined by tricuspid annular plane systolic excursion (TAPSE)

scientific article published on 26 March 2014

In vitro oxidation of LDL by ozone

scientific article published on 13 May 2014

Incidence and natural history of neonatal isolated ventricular septal defects: Do we know everything? A 6-year single-center Italian experience follow-up

scientific article published on 30 August 2017

Isovolumic acceleration measurement at the lateral tricuspid annulus: a promising parameter in pediatric right heart function determination

scientific article published on 01 March 2015

Laser Acupuncture for Neonatal Abstinence Syndrome: A Randomized Controlled Trial.

scientific article published on 26 October 2015

Late development of a large intrahepatic fistula after "closure" of an atrial septal defect

scientific article published on 23 February 2009

Left and Right Atrial Strain in Healthy Caucasian Children by Two-Dimensional Speckle-Tracking Echocardiography

scientific article published on 17 November 2018

Left ventricular long-axis function: reference values of the mitral annular plane systolic excursion in 558 healthy children and calculation of z-score values.

scientific article published on 20 June 2012

Left ventricular-right ventricular interaction in paediatric idiopathic dilated cardiomyopathy

scientific article published on 8 February 2013

Letter to the editor regarding "abnormalities in echocardiographic indices of right ventricular systolic function in children with elevated pulmonary artery pressure".

scientific article

Longitudinal systolic left ventricular function in preterm and term neonates: reference values of the mitral annular plane systolic excursion (MAPSE) and calculation of z-scores

scientific article published on 31 July 2014

Longitudinal systolic ventricular interaction in pediatric and young adult patients with TOF: a cardiac magnetic resonance and M-mode echocardiographic study

scientific article published on 3 July 2013

M-Mode and tissue Doppler imaging derived normal values of left and right ventricular function in healthy infants

scientific article published on 2 December 2012

Mature and immature platelets during the first week after birth and incidence of patent ductus arteriosus

scientific article published on 28 April 2020

Menstrual Phase Affects Coagulation and Hematological Parameters during Central Hypovolemia

scientific article published on 27 September 2020

Mitral annular peak systolic velocity in pediatric patients with ectopic atrial tachycardia

scientific article published on 5 May 2015

More on: mild hemophilia A and inhibitor development

scientific article published in April 2004

Myocardial infarction in an adolescent: anomalous origin of the left main coronary artery from the right coronary sinus in association with combined prothrombotic defects

scientific article published on 01 August 2007

Near-infrared spectroscopy for objectifying cerebral effects of laser acupuncture in term and preterm neonates

scientific article

Nomograms for echocardiographic right ventricular sub-costal view dimensions in healthy Caucasian children: A new approach to measure the right ventricle.

scientific article published on 8 September 2017

Nomograms of pulsed Doppler velocities, times, and velocity time integrals for semilunar valves and great arteries in healthy Caucasian children

scientific article published on 03 March 2019

Non-Invasive Imaging for Congenital Heart Disease: Recent Innovations in Transthoracic Echocardiography

scientific article

Normal Pediatric Values of the Subcostal Tricuspid Annular Plane Systolic Excursion (S-TAPSE) and Its Value in Pediatric Pulmonary Hypertension

scientific article published on 02 February 2019

Normal Reference Values and z Scores of the Pulmonary Artery Acceleration Time in Children and Its Importance for the Assessment of Pulmonary Hypertension

scientific article published in January 2017

Normal basic 2D echocardiographic values to screen and follow up the athlete's heart from juniors to adults: What is known and what is missing. A critical review

scientific article published on 02 July 2019

Normative Data for Left and Right Ventricular Systolic Strain in Healthy Caucasian Italian Children by Two-Dimensional Speckle-Tracking Echocardiography

scientific article published on 08 March 2018

Novel algorithm to screen for heart murmurs using computer-aided auscultation in neonates: a prospective single center pilot observational study

scientific article published on 02 July 2018

One-year safe use of the Prismaflex HF20(®) disposable set in infants in 220 renal replacement treatment sessions

scientific article published on 19 February 2011

Orthostatic Challenge Shifts the Hemostatic System of Patients Recovered from Stroke toward Hypercoagulability.

scientific article published on 07 February 2017

PFA-100 closure times in preoperative screening in 500 pediatric patients

scientific article published on 01 July 2007

Pediatric echocardiographic nomograms: What has been done and what still needs to be done

scientific article published on 19 January 2017

Pediatric patients with congenital heart disease: thrombin generation measured by calibrated automated thrombography

scientific article published in July 2008

Perioperative Right Ventricular Systolic Function Determination in Children With Tetralogy of Fallot

scientific article published on 03 April 2019

Pulmonary arterial wall thickness as a promising echocardiographic follow-up parameter in severe pediatric pulmonary hypertension

scientific article published on 29 September 2015

Quantification of Left Ventricular Size and Function by 2-Dimensional Echocardiography: So Basic and So Difficult: How to Increase the Accuracy and Reproducibility in Children?

scientific article published in November 2017

Racial differences of the tricuspid annular plane systolic excursion

scientific article published on 01 February 2015

Radial and longitudinal right ventricular function in children

scientific article published on 01 August 2014

Recombinant human activated protein C, heparin and melagatran in umbilical cord versus adult plasma

scientific article published in July 2005

Recommendations from the Association for European Paediatric and Congenital Cardiology for training in pulmonary hypertension

scientific article published on 26 September 2019

Reference values and calculation of z-scores of echocardiographic measurements of the normal pediatric right ventricle

scientific article published on 27 August 2014

Reference values of the mitral annular peak systolic velocity (Sm) in 690 healthy pediatric patients, calculation of Z-score values, and comparison to the mitral annular Plane systolic excursion (MAPSE).

scientific article published on 7 February 2014

Reference values of the right ventricular outflow tract (RVOT) proximal diameter in 665 healthy children and calculation of Z-score values

scientific article published on 16 October 2013

Reference values of the right ventricular outflow tract systolic excursion in 711 healthy children and calculation of z-score values

scientific article published on 23 March 2014

Reference values of tricuspid annular peak systolic velocity in healthy pediatric patients, calculation of z score, and comparison to tricuspid annular plane systolic excursion

scientific article published on 23 September 2011

Relevance of Right Ventricular Outflow Tract Velocity Time Integral (RVOT VTI) and Tricuspid Regurgitation Velocity/RVOT VTI Ratio Determination in Children Following Heart Transplantation

scientific article published on 13 February 2018

Relevance of longitudinal systolic heart function in fetuses with intrauterine growth restriction

scientific article published on 01 January 2014

Relevance of tissue Doppler imaging for assessment of right ventricular performance in preterm neonates

scientific article published on 28 March 2015

Relevance of tricuspid annular peak systolic velocity (s') to detect systolic right-ventricular impairment after anthracycline cancer treatment in childhood.

scientific article

Remote monitoring leads to early recognition and treatment of critical arrhythmias in adults after atrial switch operation for transposition of the great arteries.

scientific article

Reply to "Diagnostic and prognostic value of echocardiography in pulmonary arterial hypertension"

scientific article published on 21 August 2018

Right Atrial Dilatation, Determined by Echocardiography, and Correlation with Right Atrial Pressure, Determined with Cardiac Catheterization, in Children with Pulmonary Hypertension

scientific article published on 02 June 2016

Right Ventricular Outflow Tract (RVOT) Changes in Children with an Atrial Septal Defect: Focus on RVOT Velocity Time Integral, RVOT Diameter, and RVOT Systolic Excursion

scientific article published in September 2016

Right Ventricular Outflow Tract Velocity Time Integral Determination in 570 Healthy Children and in 52 Pediatric Atrial Septal Defect Patients.

scientific article

Right Ventricular Size and Function in Neonates after Use of Antidepressants during Pregnancy

scientific article published on 11 June 2019

Right ventricular base/apex ratio in the assessment of pediatric pulmonary arterial hypertension: Results from the European Pediatric Pulmonary Vascular Disease Network

scientific article published on 18 August 2018

Right ventricular end-systolic remodeling index in the assessment of pediatric pulmonary arterial hypertension. The European Pediatric Pulmonary Vascular Disease Network (EPPVDN)

scientific article published on 10 January 2020

Right ventricular function impairment in children after tetralogy of fallot repair

scientific article published on 01 March 2014

Right ventricular function in Juvenile idiopathic arthritis patients

scientific article published on 08 August 2012

Right ventricular function in infants, children and adolescents: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 640 healthy patients and calculation of z score values

scientific article

Right ventricular function in systemic sclerosis-associated pulmonary arterial hypertension

scientific article published on 01 January 2013

Right ventricular function parameters in the neonatal population

scientific article published on 20 December 2011

Right ventricular long-axis response to different loading conditions

scientific article

Right ventricular outflow tract velocity time integral (RVOT VTI) and tricuspid regurgitation velocity/RVOT VTI ratio in pediatric pulmonary hypertension.

scientific article published on 24 March 2016

Right ventricular performance in preterm and term neonates: reference values of the tricuspid annular peak systolic velocity measured by tissue Doppler imaging

scientific article

Right ventricular stroke work in children with pulmonary arterial hypertension: a promising approach

scientific article published on 16 July 2014

Right ventricular systolic function, determined by echocardiography, after percutaneous balloon valvuloplasty in children with isolated pulmonary stenosis

scientific article published on 04 February 2017

Selexipag for the treatment of children with pulmonary arterial hypertension: First multicenter experience in drug safety and efficacy

scientific article published on 07 April 2020

Should we use the oral selective IP receptor agonist selexipag off-label in children with pulmonary arterial hypertension?

scientific article published on 01 July 2018

Signs of thrombin generation in pediatric cardiac catheterization with unfractionated heparin bolus or subcutaneous low molecular weight heparin for antithrombotic cover

scientific article published in January 2003

Stent implantation in the superficial femoral artery: short thrombelastometry-derived coagulation times identify patients with late in-stent restenosis

scientific article published on 29 April 2012

Subclinical deterioration of systolic right ventricular function parameters in adolescents with mild cystic fibrosis

scientific article published on 10 November 2012

Successful occlusion of a persistent left vertical vein with an Amplatzer muscular ventricular septal defect occluder

scientific article published on 04 June 2007

Systolic Right Ventricular Function in Children with Cystic Fibrosis

scientific article published on 13 April 2016

Systolic right ventricular function in children and young adults with pulmonary artery hypertension secondary to congenital heart disease and tetralogy of Fallot: tricuspid annular plane systolic excursion (TAPSE) and magnetic resonance imaging data

scientific article

Systolic right ventricular function in pediatric and adolescent patients with tetralogy of Fallot: echocardiography versus magnetic resonance imaging

scientific article published on 12 November 2010

Systolic right-ventricular function impairment in healthy children after endurance stress.

scientific article published on 13 July 2013

The anticoagulant action of recombinant human activated protein C (rhAPC, Drotrecogin alpha activated): comparison between cord and adult plasma

scientific article published in May 2004

The respective and combined anticoagulant effects of recombinant human activated protein C, melagatran and heparins using CAT.

scientific article published on 19 May 2006

The right ventricular outflow tract in pediatric pulmonary hypertension-Data from the European Pediatric Pulmonary Vascular Disease Network.

scientific article published on 5 March 2018

Three-Dimensional Echocardiography Derived Nomograms for Left Ventricular Volumes in Healthy Caucasian Italian Children

scientific article published on 01 April 2019

Thrombin generation determined by calibrated automated thrombography (CAT) in pediatric patients with congenital heart disease

scientific article published on 03 October 2007

Thrombin generation in factor VIII-depleted neonatal plasma: nearly normal because of physiologically low antithrombin and tissue factor pathway inhibitor

scientific article published in May 2006

Thrombin generation in paediatric patients with congenital heart disease. Determination by calibrated automated thrombography.

scientific article published in October 2008

Transcarotid balloon valvuloplasty for critical aortic stenosis in a premature neonate weighing 1100 g

scientific article published on 01 June 2010

Transcatheter closure of an atrial septal defect in a newborn with aortic stenosis

scientific article published on 27 November 2008

Transthoracic echocardiography for the evaluation of children and adolescents with suspected or confirmed pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric

scientific article published in May 2016

Transthoracic echocardiography in the evaluation of pediatric pulmonary hypertension and ventricular dysfunction

scientific article

Tricuspid Annular Plane Systolic Excursion Is Reduced in Infants with Pulmonary Hypertension: Value of Tricuspid Annular Plane Systolic Excursion (TAPSE) to Determine Right Ventricular Function in Various Conditions of Pediatric Pulmonary Hypertensi

scientific article published on 03 March 2015

Tricuspid annular peak systolic velocity (S') in children and young adults with pulmonary artery hypertension secondary to congenital heart diseases, and in those with repaired tetralogy of Fallot: echocardiography and MRI data

scientific article

Tricuspid annular peak systolic velocity (s') in pediatric patients with mild cystic fibrosis

scientific article published on 10 January 2013

Tricuspid annular plane systolic excursion (TAPSE) in pediatric pulmonary hypertension: Integrating right ventricular ejection efficiency (RVEe) into advanced multi-parametric imaging

scientific article published on 03 July 2018

Tricuspid annular plane systolic excursion and right ventricular ejection fraction in pediatric and adolescent patients with tetralogy of Fallot, patients with atrial septal defect, and age-matched normal subjects

scientific article published on 12 September 2010

Use of linear and convex ultrasound transducers for evaluation of retrosternal area in patients after cardiac surgery

scientific article published on 21 December 2017

Value of Right Ventricular Dilatation, Determined by Echocardiography, in Estimating Hemodynamic Significance in Children with Atrial Septal Defect

scientific article published on 09 May 2016

Value of systolic right ventricular function parameters in children with pulmonary arterial hypertension associated with congenital heart diseases

scientific article published on 18 September 2013

Value of the tricuspid annular plane systolic excursion as a follow-up parameter in patients with hypoplastic left heart syndrome

scientific article published on 01 June 2013

Value of tricuspid annular peak systolic velocity (s') measurement in scleroderma-associated pulmonary arterial hypertension: comment on the article by Gopal et al

scientific article published on 01 October 2014

Value of tricuspid annular plane systolic excursion and peak systolic velocity in children with pulmonary hypertension

scientific article published on 03 October 2012

Ventricular-ventricular interaction variables correlate with surrogate variables of clinical outcome in children with pulmonary hypertension.

scientific article published in April 2019

Virtually same oxidizability of LDL but higher Lp(a) levels in arterial compared to venous plasma

scientific article published on 18 September 2014

Why Use Percentiles and Not Z Scores to Calculate Pediatric Echocardiographic Nomograms? The Need for a Uniform Approach to Data Normalization

scientific article published on 18 June 2018

Z-Value of Mitral Annular Plane Systolic Excursion Is a Useful Indicator to Predict Left Ventricular Stroke Volume in Children: Comparing Longitudinal and Radial Contractions

scientific article published on 01 February 2016