List of works by Pamela Lein

2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice

scientific article

3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism

scholarly article by Sunjay Sethi et al published November 2018 in Archives of Toxicology

A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films

A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.

scientific article

A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling

scientific article published on 21 June 2017

A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression

scientific article

A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation

scientific article

Acute hippocampal slice preparation and hippocampal slice cultures

scientific article

Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers

scientific article

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats

scientific article published on 11 September 2020

Animal models of autism spectrum disorders: information for neurotoxicologists

scientific article

Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity

scientific article

BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action

scientific article published on 20 March 2017

BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.

scientific article published on 13 December 2015

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine

scientific article (publication date: 2015)

Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio)

article published in 2018

Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers

journal article published in 2011

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

scientific article

Bone morphogenetic proteins regulate ionotropic glutamate receptors in human retina

scientific article published in October 2004

Cerebrospinal fluid contains biologically active bone morphogenetic protein-7.

scientific article published in December 2001

Changes in thyroid hormone activity disrupt photomotor behavior of larval zebrafish

scientific article published on 20 May 2019

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine

scientific article

Characterization of α-cypermethrin exposure in Egyptian agricultural workers

scientific article

Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity

scientific article

Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase

scientific article

Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures

scientific article published in September 2005

Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior

scientific article

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

scientific article published on 14 April 2015

Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor

scientific article published on 19 March 2019

Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure

scientific article

Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells

scientific article published on 9 April 2008

Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences

scientific article

Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity

Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns

scientific article published on 29 December 2016

Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons

scientific article published on 16 May 2017

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

scientific article

Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats

scientific article published on 17 August 2020

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats

scientific article published on April 2008

Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats

scientific article published on 12 September 2008

Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio

scientific article

Distinct spatial localization of specific mRNAs in cultured sympathetic neurons

scientific article published on 01 December 1990

Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity

scientific article published on 14 April 2017

Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.

scientific article published on 7 March 2017

Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice

scientific article

Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes

scientific article published on 01 October 1988

Effects of cytokines on nuclear factor-kappa B, cell viability, and synaptic connectivity in a human neuronal cell line

scientific article published on 21 January 2020

Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats

scientific article published on 27 May 2020

Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio)

scientific article published on 15 November 2018

Emerging concepts in neurotoxicology: Models, mechanisms and modifying factors

scientific article published on 12 April 2012

Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures

scientific article

Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity

scientific article published on 04 February 2020

Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos

journal article published in 2012

Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals

scientific article

Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons

scientific journal article

From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms

scientific article

From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.

scientific article

Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice

scientific article published on 10 December 2014

High abundant protein removal from rodent blood for biomarker discovery

scientific article

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies

scientific article published on 24 January 2020

Immunologic and neurodevelopmental susceptibilities of autism

scientific article

In vitro and other alternative approaches to developmental neurotoxicity testing (DNT).

scientific article published on 25 January 2005

In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons

scientific article published on 16 August 2017

Increased Severity of Fragile X Spectrum Disorders in the Agricultural Community of Ricaurte, Colombia

scientific article published on 29 October 2018

Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats

scientific article

Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in vitro

scientific article published on 01 December 1989

Laminin selectively enhances axonal growth and accelerates the development of polarity by hippocampal neurons in culture

scientific article published in October 1992

Leukemia inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of rat sympathetic neurons

scientific article published in December 1997

Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers

scientific article

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs

scientific article

Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins.

scientific article

Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces.

scientific article published on 31 May 2016

Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation

scientific article

Mechanisms of neuronal polarity

scientific article published on 01 October 1997

Mechanisms of organophosphate insecticide-induced airway hyperreactivity

scientific article

Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma

article

Meeting report: alternatives for developmental neurotoxicity testing

scientific article published on 29 January 2007

Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent

scientific article published on 12 April 2013

Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker

scientific article

Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron

scientific article published on 10 June 2014

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

scientific article

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents

scientific article

Mutagenic activity of surface waters adjacent to a nuclear fuel processing facility

scientific article published on 01 September 1987

Mutant IDH1 and seizures in patients with glioma.

scientific article published on 12 April 2017

Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance.

scientific article

Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size.

scientific article published on 2 March 2015

Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity.

scientific article

Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society.

scientific article published in March 2017

Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury

scientific article

Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury

scientific article published on 11 May 2012

Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders

scientific article

Neurotoxicity in preclinical models of occupational exposure to organophosphorus compounds

journal article published in 2017

Neurotoxicity of polychlorinated biphenyls and related organohalogens

scientific article published on 11 April 2019

Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons

scientific article

Nucleic acid binding agents exert local toxic effects on neurites via a non-nuclear mechanism

scientific article

Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls

scientific article published on 16 January 2007

Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons

scientific article

Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells

scientific article published on 01 November 2019

Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms

scientific article

Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons

scientific article published on 01 September 1995

Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line

scientific article

PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms

scientific article

PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms

scholarly article by Kimberly P Keil et al published October 2018 in Archives of Toxicology

PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth

scientific article

PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms

scientific article

PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos

scientific article

Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity

scientific article

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

scientific article published on 12 October 2016

Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos

scientific article

Phenobarbital use and neurological problems in FMR1 premutation carriers

scientific article

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

scientific article published on 01 March 2022

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

scientific article published on 17 September 2020

Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor

scientific article published in July 2003

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication

scientific article

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication

scientific article published on 07 March 2019

Protein synthesis is required for the initiation of dendritic growth in embryonic rat sympathetic neurons in vitro

scientific article published in June 1991

Putative adverse outcome pathways relevant to neurotoxicity

scientific article

Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture

scientific article

Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons

scientific article

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

scientific article

Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides

scientific article published on 13 January 2016

Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation

scientific article

Sex-dependent effects of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on dendritic arborization of primary mouse neurons

scientific article published on 01 March 2019

Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication

scientific article

Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11).

scientific article published on 23 December 2017

Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation

scientific article

Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons

scientific article

Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.

scientific article

Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists

scientific article published on 04 December 2019

Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio)

scientific article published on 01 January 2019

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation

scientific article

The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats

scholarly article by Frances C Shaffo et al published 1 September 2018 in Toxicological Sciences

The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity

scientific article published on 18 April 2020

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

scientific article published on 12 November 2019

The effects of extracellular matrix and osteogenic protein-1 on the morphological differentiation of rat sympathetic neurons.

scientific article published in June 1996

The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.

scientific article published on January 2014

The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity

scientific article

The novel GTPase Rit differentially regulates axonal and dendritic growth

scientific article

Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth

scientific article (publication date: 2011)

Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95.

scientific article

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

scientific article

Translational Toxicology in Zebrafish

scientific article published on 08 June 2020

Using the Morris water maze to assess spatial learning and memory in weanling mice

scientific article

Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models

scientific article

Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies

scientific article published on 6 February 2007

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