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List of works by Breandan N Kennedy

1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature

scientific article published in 2024

A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model.

scientific article published on 12 September 2017

A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab

scientific article published on 29 December 2016

A method for isolation of cone photoreceptors from adult zebrafish retinae

scientific article

A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy

scientific article published on 5 May 2016

A novel, evolutionarily conserved enhancer of cone photoreceptor-specific expression

scientific article

A sustained release formulation of novel quininib-hyaluronan microneedles inhibits angiogenesis and retinal vascular permeability in vivo.

scientific article published on 13 April 2016

Applying transgenic zebrafish technology to study the retina.

scientific article published on January 2006

Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration

scientific article

CRALBP transcriptional regulation in ciliary epithelial, retinal Müller and retinal pigment epithelial cells

scientific article

Calcitriol and Non-Calcemic Vitamin D Analogue, 22 Oxacalcitriol, Attenuate Developmental and Pathological Ocular Angiogenesis Ex Vivo and In Vivo

Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo

scientific article published on 04 February 2020

Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells

scientific article published on 20 February 2019

Characterisation of expression patterns and functional role of Cactin in early zebrafish development

scientific article published on 27 March 2010

Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

scientific article published on 26 February 2020

Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4

scientific article published on 01 May 2020

Current and emerging therapies for ocular neovascularisation.

scientific article published on January 2014

Deciphering combinations of PI3K/AKT/mTOR pathway drugs augmenting anti-angiogenic efficacy in vivo

scientific article

Duplication and divergence of zebrafish CRALBP genes uncovers novel role for RPE- and Muller-CRALBP in cone vision

scientific article published on 23 May 2008

Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis

scientific article published on 26 August 2019

Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response

scientific article

Emerging Drug Therapies for Inherited Retinal Dystrophies

scientific article published on 01 January 2019

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

scientific article published on 11 April 2018

Establishment and characterization of a retinal Müller cell line.

scientific article published in January 1998

Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer

scientific article

Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma

scientific article published on 01 September 2018

First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype

scientific article (publication date: December 2011)

GATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation end products

scientific article published on 21 March 2022

Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis

scientific article

Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration

scientific article published on 17 March 2020

Genetic determinants of hyaloid and retinal vasculature in zebrafish

scientific article

Genome editing: the breakthrough technology for inherited retinal disease?

scientific article

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

scientific article published on 13 October 2020

Histone Deacetylase: Therapeutic Targets in Retinal Degeneration

scientific article published on 01 January 2016

Identification of a zebrafish cone photoreceptor-specific promoter and genetic rescue of achromatopsia in the nof mutant

scientific article published in February 2007

Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis

scientific article

Inhibition of the Pim1 oncogene results in diminished visual function

scientific article

Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data

scientific article

Isolation of a zebrafish rod opsin promoter to generate a transgenic zebrafish line expressing enhanced green fluorescent protein in rod photoreceptors.

scientific article

Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof.

scientific article published in January 2003

Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.

scientific article

Molecular characterization of the mouse gene encoding cellular retinaldehyde-binding protein

scientific article published on September 4, 1998

Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa

scientific article

Non-photopic and photopic visual cycles differentially regulate immediate, early and late-phases of cone photoreceptor-mediated vision

scientific article published on 01 April 2020

Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

scientific article published on 24 May 2019

PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors

scientific article

Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease

scientific article published on 27 February 2019

Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis

scientific article published on 4 February 2016

Photoreceptor guanylate cyclases and cGMP phosphodiesterases in zebrafish

scientific article published on January 2010

Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer.

scientific article published on 14 October 2016

Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy.

scientific article published on 8 February 2010

Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

scientific article published on 21 July 2020

Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish

scientific article published on 4 December 2017

Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.

scientific article published on 19 December 2016

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

scientific article published on 26 August 2020

Selective inhibition of retinal angiogenesis by targeting PI3 kinase

scientific article

Targeting the PI3K/Akt/mTOR pathway in ocular neovascularization

scientific article published on January 2014

The genetics of outer segment morphogenesis in zebrafish.

scientific article published on January 2012

The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration

scientific article published on 01 January 2019

Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology.

scientific article published on 15 January 2013

Unexpected genetic heterogeneity for primary ciliary dyskinesia in the Irish Traveller population.

scientific article

Vacuolar ATPases and their role in vision.

scientific article published on January 2014

Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation

scientific article published in March 2001

Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre-miR-21 and VEGF.

scientific article

Zebrafish Tg(7.2mab21l2:EGFP)ucd2 transgenics reveal a unique population of retinal amacrine cells

scientific article

Zebrafish rx3 and mab21l2 are required during eye morphogenesis

scientific article

mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation

scientific article published on 28 February 2011

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