List of works - Nobuhiko Kamada

A complex microworld in the gut: Harnessing pathogen-commensal relations

scientific article published on 01 August 2012

A novel apoptosis-inducing monoclonal antibody (anti-LHK) against a cell surface antigen on colon cancer cells

scientific article published in October 2005

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

scientific article published in June 2013

A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice

scientific article published on 01 April 2019

Activated hepatic stellate cells mediate the differentiation of macrophages

scientific article published on 29 October 2012

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.

scientific article published in June 2012

Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions

scientific article published on 25 November 2011

Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis

scientific article published on 01 September 2010

Control of pathogens and pathobionts by the gut microbiota

scientific article

Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease

scientific article

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

scientific article published on 15 June 2016

Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut

scientific article published on 04 November 2019

Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages.

scientific article published on 7 October 2008

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

scientific article published on 7 April 2015

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

scientific article

Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes

scientific article published on 01 July 2007

Functional Characterization of Inflammatory Bowel Disease-Associated Gut Dysbiosis in Gnotobiotic Mice

scientific article published on 03 March 2016

Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.

scientific article published on July 2009

Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability.

scientific article published on 10 July 2009

Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.

scientific article published on 30 April 2015

IL-10 produced by macrophages regulates epithelial integrity in the small intestine

scientific article published in Scientific Reports

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

scientific article published on 24 July 2008

Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease

scientific article

Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease

scientific article published in June 2010

Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

scientific article

Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis

scientific article published on 01 April 2006

Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.

scientific article

Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

scientific article published on 17 February 2020

Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.

scientific article

Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages.

scientific article published on 24 February 2011

Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells.

scientific article published on 21 May 2007

Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3

scientific article published on 07 October 2020

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation.

scientific article

Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity

scientific article published in 2022

Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes.

scientific article published on 3 July 2017

Microbial adaptation to the healthy and inflamed gut environments

scientific article published on 01 November 2020

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

scientific article published on 30 January 2012

Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset

scientific article published on 27 January 2010

Multiple effects of dendritic cell depletion on murine norovirus infection

scientific article published on May 2013

NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity ⬇️

scientific article published on March 7, 2011

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

scientific article published on 11 April 2016

Nonpathogenic Escherichia coli strain Nissle1917 prevents murine acute and chronic colitis.

scientific article

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen

scientific article published on 16 March 2011

Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop

scientific article published on 10 August 2012

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.

scientific article

Regulation of the immune system by the resident intestinal bacteria.

scientific article published on 04 February 2014

Regulation of virulence: the rise and fall of gastrointestinal pathogens.

scientific article published on 10 November 2015

Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells

scientific article

Role of the gut microbiota in the development and function of lymphoid cells.

scientific article published on February 2013

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

scientific article

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

scientific article published on May 2013

TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease

scientific article published in April 2010

Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice

scientific article

Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.

scientific article

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.

scientific article published on 22 September 2015

The Bacterial Connection between the Oral Cavity and the Gut Diseases

scientific article published on 28 May 2020

The tuning of the gut nervous system by commensal microbiota

scientific article published in December 2013

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology

scientific article

Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis

scientific article published on June 2008

[Pathogenic roles of intestinal macrophages in inflammatory bowel disease]

scientific article published on 01 April 2009

List of works by Nobuhiko Kamada

A complex microworld in the gut: Harnessing pathogen-commensal relations

A novel apoptosis-inducing monoclonal antibody (anti-LHK) against a cell surface antigen on colon cancer cells

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice

Activated hepatic stellate cells mediate the differentiation of macrophages

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.

Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions

Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis

Control of pathogens and pathobionts by the gut microbiota

Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut

Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages.

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes

Functional Characterization of Inflammatory Bowel Disease-Associated Gut Dysbiosis in Gnotobiotic Mice

Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.

Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability.

Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.

IL-10 produced by macrophages regulates epithelial integrity in the small intestine

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease

Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease

Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis

Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.

Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.

Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages.

Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells.

Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation.

Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity

Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes.

Microbial adaptation to the healthy and inflamed gut environments

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset

Multiple effects of dendritic cell depletion on murine norovirus infection

NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity ⬇️

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

Nonpathogenic Escherichia coli strain Nissle1917 prevents murine acute and chronic colitis.

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen

Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.

Regulation of the immune system by the resident intestinal bacteria.

Regulation of virulence: the rise and fall of gastrointestinal pathogens.

Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells

Role of the gut microbiota in the development and function of lymphoid cells.

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease

Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice

Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.

The Bacterial Connection between the Oral Cavity and the Gut Diseases

The tuning of the gut nervous system by commensal microbiota

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology

Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis

[Pathogenic roles of intestinal macrophages in inflammatory bowel disease]