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List of works by David J. Klinke

A multi-scale model of dendritic cell education and trafficking in the lung: implications for T cell polarization

scientific article

A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12

scientific article published on 15 September 2010

A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model

scientific article

Age-corrected beta cell mass following onset of type 1 diabetes mellitus correlates with plasma C-peptide in humans

scientific article

An age-structured model of dendritic cell trafficking in the lung.

scientific article published on November 2006

An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets

scientific article published on 22 August 2019

An empirical Bayesian approach for model-based inference of cellular signaling networks

scientific article

An evolutionary perspective on anti-tumor immunity

scientific article published on January 2012

An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

scientific article published on 08 January 2020

CD8(+) T cell response to adenovirus vaccination and subsequent suppression of tumor growth: modeling, simulation and analysis

scientific article published on 6 June 2015

Cell Communication Network Factor 4 (CCN4/WISP1) Shifts Melanoma Cells from a Fragile Proliferative State to a Resilient Metastatic State

scientific article published on 17 October 2019

Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis

scientific article

Eavesdropping on altered cell-to-cell signaling in cancer by secretome profiling

scientific article published on 14 April 2015

Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study

scientific article

Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration

scientific article published on 5 February 2018

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers.

scientific article published on 02 September 2015

Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus

scientific article

Identification and classification of bcl genes and proteins of Bacillus cereus group organisms and their application in Bacillus anthracis detection and fingerprinting

scientific article published on 18 September 2009

Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs.

scientific article published on 19 January 2016

Identifying local mechanisms for tumor-derived immunosuppression: an integrated phenotypic screening approach

scientific article published on 6 November 2014

In silico model-based inference: a contemporary approach for hypothesis testing in network biology

scientific article

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines

scientific article

Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study

scientific article (publication date: 2014)

Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models

scientific article

Inferring predominant pathways in cellular models of breast cancer using limited sample proteomic profiling

scientific article

Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells

scientific article

Inferring the Impact of Regulatory Mechanisms that Underpin CD8+ T Cell Control of B16 Tumor Growth In vivo Using Mechanistic Models and Simulation

scientific article published on January 2016

Integrating epidemiological data into a mechanistic model of type 2 diabetes: validating the prevalence of virtual patients

scientific article

Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway.

scientific article

Is immune checkpoint modulation a potential therapeutic option in triple negative breast cancer?

scientific article published on 7 November 2014

Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function.

scientific article published on 08 December 2016

Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer

scientific article published on 22 February 2012

Quantifying crosstalk among interferon-γ, interleukin-12, and tumor necrosis factor signaling pathways within a TH1 cell model

scientific article

Scalable analysis of flow cytometry data using R/Bioconductor

scientific article published in August 2009

Signal transduction networks in cancer: quantitative parameters influence network topology

scientific article

Simulation Study on Effects of Order and Step Size of Runge-Kutta Methods that Solve Contagious Disease and Tumor Models

scientific article published on 30 September 2016

The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity

scientific article

Timescale analysis of rule‐based biochemical reaction networks ⬇️

scientific article published on September 26, 2011

Understanding immunology via engineering design: the role of mathematical prototyping.

scientific article

WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition

scientific article published on 05 February 2019

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