List of works - Daniel Krappmann

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

scientific article published on 28 August 2017

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

scientific article

A20 and CYLD do not share significant overlapping functions during B cell development and activation

scientific article published on 21 September 2012

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

scientific article

AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation.

scientific article published on 22 July 2014

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

scientific article published on August 2002

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas

scientific article

Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells

scientific article

Attacking MALT1 for ABC-DLBCL therapy ⬇️

scientific article published on December 1, 2012

B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.

scientific article published on 18 November 2016

BCL10 - Bridging CARDs to Immune Activation

scientific article published on 04 July 2018

BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

scientific article published on 20 November 2018

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

scientific article published on 28 May 2019

CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB.

scientific article

COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation

scientific article

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

scientific article

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation

scientific article

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.

scientific article

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

scientific article published in May 2001

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells ⬇️

scientific article published on December 15, 1997

Controlling NF-kappaB activation in T cells by costimulatory receptors

scientific article

Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

scientific article published on 01 August 2019

Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

scientific article

Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling

scientific article

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

scientific article

Detection of recombinant and cellular MALT1 paracaspase activity

scientific article published in January 2015

Development of new Malt1 inhibitors and probes.

scientific article

Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells

scientific article

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases

scientific journal article

Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation

scientific article published in July 2006

GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10.

scientific article published on 22 January 2018

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

scientific article published in Nature Communications

Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.

scientific article published on 31 January 2017

In vitro detection of NEMO-ubiquitin binding using DELFIA and microscale thermophoresis assays.

scientific article

In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity.

scientific article

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma

scientific article published on 19 August 2016

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

scientific article published on 7 January 2016

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

scientific article published in November 2009

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome.

scientific article

Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism

scientific article

MALT1 activation by TRAF6 needs neither BCL10 nor CARD11

scientific article published on 15 October 2018

MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

scientific article published on 29 July 2007

MALT1 protease: equilibrating immunity versus tolerance.

scientific article published on 31 October 2014

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

scientific article

Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies

scientific article published on 27 January 2014

Mechanisms of NF-κB deregulation in lymphoid malignancies

scientific article

Molecular architecture and regulation of BCL10-MALT1 filaments

scientific article published in Nature Communications

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

scientific article published on January 1999

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

scientific article

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

scientific article

Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

scientific article

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

scientific article

Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.

scientific article

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

scientific article

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

scientific article published on December 2012

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

scientific article

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

scientific article published on 17 May 2013

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.

scientific article

Purification and characterization of the human elongator complex

scientific article

Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma

scientific article published on 22 March 2019

Regulation of the endosomal SNX27-retromer by OTULIN

scientific article published on 20 September 2019

Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

scientific article published on July 2004

Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation

scientific article

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells ⬇️

scientific article published on 7 September 2017

Shaping oncogenic NF-κB activity in the nucleus

scientific article published in September 2013

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

scientific article

Signal-dependent degradation of I B is mediated by an inducible destruction box that can be transferred to NF- B, Bcl-3 or p53 ⬇️

scientific article published on April 1, 1998

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

scientific article published on 18 January 2011

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

scientific article

Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome.

scientific article published on 15 January 2016

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

scientific article published on 27 June 2018

The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation ⬇️

scientific article published on January 3, 2011

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

scientific article

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component

scientific article published in September 2000

The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.

scientific article

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

scientific article

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

scientific article

Ubiquitin Conjugation and Deconjugation in NF-κB Signaling

scientific article published on January 2010

Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.

scientific article

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

scientific article

List of works by Daniel Krappmann

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

A20 and CYLD do not share significant overlapping functions during B cell development and activation

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation.

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas

Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells

Attacking MALT1 for ABC-DLBCL therapy ⬇️

B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.

BCL10 - Bridging CARDs to Immune Activation

BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB.

COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells ⬇️

Controlling NF-kappaB activation in T cells by costimulatory receptors

Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

Detection of recombinant and cellular MALT1 paracaspase activity

Development of new Malt1 inhibitors and probes.

Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases

Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation

GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10.

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.

In vitro detection of NEMO-ubiquitin binding using DELFIA and microscale thermophoresis assays.

In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity.

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome.

Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism

MALT1 activation by TRAF6 needs neither BCL10 nor CARD11

MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

MALT1 protease: equilibrating immunity versus tolerance.

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies

Mechanisms of NF-κB deregulation in lymphoid malignancies

Molecular architecture and regulation of BCL10-MALT1 filaments

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.

Purification and characterization of the human elongator complex

Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma

Regulation of the endosomal SNX27-retromer by OTULIN

Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells ⬇️

Shaping oncogenic NF-κB activity in the nucleus

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

Signal-dependent degradation of I B is mediated by an inducible destruction box that can be transferred to NF- B, Bcl-3 or p53 ⬇️

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome.

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation ⬇️

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component

The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

Ubiquitin Conjugation and Deconjugation in NF-κB Signaling

Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.