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List of works by Kim Brosen

A Comparative Pharmacokinetic Study in Healthy Volunteers of the Effect of Carbamazepine and Oxcarbazepine on Cyp3a4

scientific article published on 01 March 2007

A Comprehensive Review of Drug-Drug Interactions with Metformin

scientific article published on 06 May 2015

A Dual Label Oligonucleotide Ligation Assay for Detection of theCYP2C19*1, CYP2C19*2, and CYP2C19*3 Alleles Involving Time-Resolved Fluorometry

scientific article published on 01 February 1998

A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C).

scientific article

A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers

scientific article published on 6 August 2013

A fluvoxamine-caffeine interaction study

scientific article published on 01 June 1996

A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin

scientific article published in October 2013

A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype

scientific article published on 01 October 1995

A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24

scientific article published on 02 August 2019

A randomised, double-blind, placebo-controlled trial of metformin on myocardial efficiency in insulin-resistant chronic heart failure patients without diabetes

scientific article published on 21 December 2019

A randomized trial of laypersons' perception of the benefit of osteoporosis therapy: Number needed to treat versus postponement of hip fracture

scientific article published on 01 October 2003

A twin study of the trough plasma steady-state concentration of metformin

article by Tore Bjerregaard Stage et al published May 2015 in Pharmacogenetics and Genomics

Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans

scientific article published in April 2002

Adverse drug reactions and drug non-compliance as primary causes of admission to a cardiology department

scientific article published on 01 January 1988

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

scientific article published in June 1993

BCPT Focused Nordic Conference

BCPT Nordic Prize in Basic & Clinical Pharmacology & Toxicology for 2011 to Pertti J. Neuvonen ⬇️

scientific article published on March 1, 2012

BCPT Nordic Prize in Basic and Clinical Pharmacology and Toxicology for 2012 to Michael J. Mulvany

scientific article

CYP2C19*17increases clopidogrel-mediated platelet inhibition but does not alter the pharmacokinetics of the active metabolite of clopidogrel

scientific article published on 01 November 2014

CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages

scientific article

CYP2D6 genotype determination in the Danish population

scientific article published in January 1994

CYP2D6 polymorphism in relation to tramadol metabolism: a study of faroese patients

scientific article published in June 2008

CYP2D6 polymorphism in systemic lupus erythematosus patients

scientific article published on 01 March 1999

Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls

journal article published in 2006

Can the genotype or phenotype of two polymorphic drug metabolising cytochrome P450-enzymes identify oral lichenoid drug eruptions?

scientific article published on 12 May 2010

Carriers of genetic variants in the HNF1A gene are more common among dead opioid addicts than among living addicts.

scientific article

Clinical Pharmacology in Denmark in 2016 - 40 Years with the Danish Society of Clinical Pharmacology and 20 Years as a Medical Speciality

scientific article published on 29 September 2016

Clinical pharmacology in research, teaching and health care: Considerations by IUPHAR, the International Union of Basic and Clinical Pharmacology

scientific article published on 01 July 2010

Clinically important interaction between azathioprine (Imurel) and phenprocoumon (Marcoumar)

scientific article published on 01 January 1997

Clopidogrel-Paclitaxel Drug-Drug Interaction: A Pharmacoepidemiologic Study.

scientific article published on 22 February 2017

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

scientific article published on 01 January 1996

Codeine in post-operative pain

scientific article published on 01 August 1998

Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo

scientific article published in September 2005

Cytochrome P450 2D6 genotype-phenotype characterization through population pharmacokinetic modeling of tedatioxetine

scientific article published on 15 August 2021

Determination of Theophylline Metabolites in Human Liver Microsomes by High-Performance Liquid Chromatography

scientific article published on 01 October 1994

Determination of imipramine and seven of its metabolites in human liver microsomes by a high-performance liquid chromatographic method

scientific article published on 01 August 1990

Determination of quinidine, dihydroquinidine, (3S)-3-hydroxyquinidine and quinidine N-oxide in plasma and urine by high-performance liquid chromatography

scientific article published on 01 October 1994

Determination of tacrine and its metabolites in human plasma and urine by high-performance liquid chromatography and fluorescence detection

scientific article published on 01 August 1998

Determination of theophylline and its metabolites in human urine and plasma by high-performance liquid chromatography

scientific article published on 01 February 1996

Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans

scientific article published in June 1996

Dextropropoxyphene kinetics after single and repeated oral doses in man.

scientific article

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

scientific article published on 4 November 2017

Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

Dose-dependent inhibition of the CYP2D6 catalyzed oxidation of sparteine by mepyramine in healthy volunteers.

scientific article published in December 2001

Dose-dependent pharmacokinetics of delavirdine in combination with amprenavir in healthy volunteers

scientific article

Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis

scientific article published on August 1993

Drug-Metabolizing Enzymes and Therapeutic Drug Monitoring in Psychiatry

scientific article published on 01 August 1996

Duplication of CYP2D6 predicts high clearance of desipramine but high clearance does not predict duplication of CYP2D6

scientific article published on 01 May 2001

Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine

scientific article

Effect of fluvoxamine on the pharmacokinetics of quinidine.

scientific article

Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men.

scientific article published in March 2002

Effects of metformin, rosiglitazone and insulin on bone metabolism in patients with type 2 diabetes.

scientific article

Enantioselective HPLC method for quantitative determination of tramadol andO-desmethyltramadol in plasma and urine: Application to clinical studies

Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers

scientific article published on 09 June 2006

Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial.

scientific article published on 14 August 2015

Erratum to: A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers

scholarly article published in European Journal of Clinical Pharmacology

Erratum to: Carriers of genetic variants in the HNF1A gene are more common among dead opioid addicts than among living addicts.

scientific article

Escitalopram in painful polyneuropathy: a randomized, placebo-controlled, cross-over trial

scientific article

Escitalopram is a weak inhibitor of the CYP2D6-catalyzed O-demethylation of (+)-tramadol but does not reduce the hypoalgesic effect in experimental pain

scientific article

Expressing effects of osteoporosis interventions in terms of postponing of fractures

scientific article published on 09 November 2002

Expression of two drug-metabolizing cytochrome P450-enzymes in human salivary glands

scientific article published on 10 February 2008

Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro

scientific article published in November 1998

Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide*

scientific article published on 01 September 1997

Fluvoxamine inhibits the CYP2C9 catalyzed biotransformation of tolbutamide.

scientific article

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

scientific article published on 01 March 1993

GWAS-based association between RWDD3 and TECTA variants and paclitaxel induced neuropathy could not be confirmed in Scandinavian ovarian cancer patients

scientific article published on 9 August 2012

Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans.

scientific article published on 5 April 2017

Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands

journal article published in 2008

Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevity

scientific article published on 01 July 1998

Globalization means that the relationship

scientific article published in January 2014

Griseofulvin and fluvoxamine interactions with the metabolism of theophylline.

scientific article published on February 1997

HPLC Method for Determination of Rosiglitazone in Plasma

Hepatic exposure of metformin in patients with non-alcoholic fatty liver disease

scientific article published on 18 June 2019

High-performance liquid chromatography of imipramine and six metabolites in human plasma and urine

scientific article published on 01 January 1993

Imipramine and pregabalin combination for painful polyneuropathy: a randomized controlled trial

scientific article published on May 2015

Imipramine demethylation in vivo: Impact of CYP1A2, CYP2C19, and CYP3A4*

scientific article published on 01 March 1997

Imipramine metabolism in relation to the sparteine oxidation polymorphism - a family study

scientific article published on 01 December 1996

Impact of ABCB1 variants on neutrophil depression: a pharmacogenomic study of paclitaxel in 92 women with ovarian cancer

scientific article

Impact of CYP2C19 phenotypes on escitalopram metabolism and an evaluation of pupillometry as a serotonergic biomarker.

scientific article published on 29 April 2009

Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer.

scientific article published on 6 April 2010

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

scientific article published on January 1996

Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia

scientific article published on 31 August 2009

Impaired Glucose Tolerance in Healthy Men Treated with St. John's Wort.

scientific article

Implementation of a rational pharmacotherapy intervention for inpatients at a psychiatric department

scientific article published in January 2008

In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses.

scientific article published on 28 July 2016

In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids

scientific article published in May 2002

In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s

scientific article

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

scientific article published on 01 January 1993

Inhibitory effect of oral contraceptives on CYP2C19 activity is not significant in carriers of the CYP2C19*17 allele

scientific article published in October 2013

Initiation of glucose-lowering treatment decreases international normalized ratio levels among users of vitamin K antagonists: a self-controlled register study

scientific article

Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone

scientific article

Interaction between tramadol and phenprocoumon

scientific article published in The Lancet

Isozyme specific drug oxidation: Genetic polymorphism and drug-drug interactions

Isozyme specific drug oxidation: Genetic polymorphism and drug-drug interactions

Lack of Association ofOPRM1andABCB1Single-Nucleotide Polymorphisms to Oxycodone Response in Postoperative Pain

scientific article published on 01 February 2012

Lack of effect of mianserin on the symptoms of diabetic neuropathy

scientific article published on 01 January 1992

Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics.

scientific article published on 4 January 2017

Letter from the Editor

Letter from the Editor

scientific article published on 01 January 2013

Letter from the Editor

Letter from the Editor

scientific article published on 01 January 2011

Letter from the Editor

Letter from the Editor

scientific article published on 01 January 2009

Letter from the Editor

Letter from the Editor

Letter from the Editor

Letter from the Editor

Letter from the Editor

scientific article published on 13 December 2017

Letter from the Editor

scientific article published in January 2019

Letter from the Editor

scientific article published in January 2017

Limited sampling strategy for determining metformin area under the plasma concentration-time curve

scientific article published on 20 June 2016

Linkage disequilibrium between the CYP2C19*17 allele and other clinically important CYP2C allelic variants in a healthy Scandinavian population

scientific article published on 04 April 2012

Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations

scientific article published on 28 July 2010

Magnus Ingelman-Sundberg is awarded the 2018 BCPT Nordic Prize in Basic and Clinical Pharmacology and Toxicology

scientific article published on 19 October 2018

Metformin increases endogenous glucose production in non-diabetic individuals and individuals with recent-onset type 2 diabetes

scientific article published on 11 April 2019

Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

scientific article published on 01 June 1995

Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinoma

scientific article published on 7 October 2015

No evidence for taxane/platinum pharmacogenetic markers: just lack of power?

scientific article published in April 2008

Open letter on access to the BIA 10-2474 clinical trial data

scientific article published on 7 December 2016

Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol

scientific article published in April 2005

Pharmacogenetics of drug oxidation via cytochrome P450 (CYP) in the populations of Denmark, Faroe Islands and Greenland

scientific article published on 23 January 2015

Pharmacogenomics and migraine: possible implications

scientific article published on 24 January 2008

Pharmacokinetic interaction between amprenavir and delavirdine after multiple-dose administration in healthy volunteers

scientific article published in January 2003

Pharmacokinetic interaction between rifampin and the combination of indinavir and low-dose ritonavir in HIV-infected patients

scientific article

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

scientific article published on 19 February 2018

Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population.

scientific article

Philippe Grandjean is the 2015 BCPT Nordic Prize Awardee.

scientific article

Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults

journal article published in 2007

Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population

scientific article published on 16 July 2005

Preface

Probe Depth Matters in Dermal Microdialysis Sampling of Benzoic Acid after Topical Application: An ex vivo Study in Human Skin

scientific article published on 17 August 2011

Professor Folke Fritz Adolf Sjöqvist (28 May 1933-30 March 2020)

scientific article published on 05 May 2020

Professor Folke Sjöqvist is the 2013 BCPT Nordic Prize Winner in Basic & Clinical Pharmacology & Toxicology

scientific article published on 5 May 2014

Professor Jens Sølver Schou 10 October 1929-8 March 2017.

scientific article

Professor Olavi Pelkonen is the 2014 BCPT Nordic Prize Winner in Basic and Clinical Pharmacology and Toxicology

scientific article published in September 2015

Professor Thue W. Schwartz is the BCPT Nordic Prize Winner 2017 in Basic & Clinical Pharmacology & Toxicology.

scientific article published on 9 October 2017

Quantification of morphine, morphine 6-glucuronide, buprenorphine, and the enantiomers of methadone by enantioselective mass spectrometric chromatography in whole blood

scientific article published on 24 March 2015

Quantitation of metformin in human plasma and urine by hydrophilic interaction liquid chromatography and application to a pharmacokinetic study.

scientific article published in April 2014

Quantitative Determination of Tolbutamide and Its Metabolites in Human Plasma and Urine by High-Performance Liquid Chromatography and UV Detection

scientific article published on 01 December 1999

Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6.

scientific article

Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel--letter.

scientific article

Retrospective study of the impact of pharmacogenetic variants on paclitaxel toxicity and survival in patients with ovarian cancer

scientific article published on 16 February 2011

Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide

scientific article published on 19 March 2004

Risk factors in elderly taking psychotropic drugs: Significance of genetic polymorphism in drug oxidation

Role of cytochrome P450 2C8*3 (CYP2C8*3) in paclitaxel metabolism and paclitaxel-induced neurotoxicity.

scientific article

Some aspects of genetic polymorphism in the biotransformation of antidepressants

scientific article published on January 2004

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

scientific article published on 01 January 1986

Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers

scientific article published on 05 May 2015

Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group

scientific article published in January 1992

Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women

scientific article published on 6 October 2010

Tacrine is not an ideal probe drug for measuring CYP1A2 activity in vivo

scientific article

The ABCB1, rs9282564, AG and TT Genotypes and the COMT, rs4680, AA Genotype are Less Frequent in Deceased Patients with Opioid Addiction than in Living Patients with Opioid Addiction.

scientific article published on 9 April 2016

The BCPT 2016 prize to Jan Alexander, Norway.

scientific article published in July 2017

The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population

scientific article published on 31 August 2007

The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients.

scientific article

The Pharmacogenetics of Tramadol.

scientific article published on 25 April 2015

The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6.

scientific article published in January 2006

The antinociceptive effect and adverse drug reactions of oxycodone in human experimental pain in relation to genetic variations in the OPRM1 and ABCB1 genes

scientific article published on 21 October 2009

The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects

scientific article published on 12 July 2006

The hypoalgesic effect of imipramine in different human experimental pain models

scientific article published on 01 March 1995

The hypoalgesic effect of oxycodone in human experimental pain models in relation to the CYP2D6 oxidation polymorphism

scientific article published on 27 February 2009

The hypoalgesic effect of tramadol in relation to CYP2D6*

scientific article published on 01 December 1996

The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide

scientific article published in January 2006

The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors

scientific article published in August 2002

The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors

scientific article published in May 1998

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.

scientific article published in December 2011

The relative bioavailability of loratadine administered as a chewing gum formulation in healthy volunteers.

scientific article

The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARγ on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes

scientific article published on 01 April 2013

The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms

scientific article

The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: a meta-analysis

scientific article published in January 1997

Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study

scientific article published in June 2005

Tramadol relieves pain and allodynia in polyneuropathy: a randomised, double-blind, controlled trial.

scientific article

Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's O-demethylation via CYP2D6.

scientific article published on 31 March 2010

Use of Dicloxacillin and Risk of Pregnancy among Users of Oral Contraceptives

scientific article published on 16 April 2018

Using a limited sampling strategy (LSS) to investigate the interindividual pharmacokinetic variability in metformin - a large prospective trial

scientific article published on 28 October 2020

Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics

scientific article published on 30 October 2018

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

scientific article

[The genome and pharmacology] ⬇️

scientific article published on 01 November 2014

[The use of the monoamine oxidase inhibitor isocarboxazide in treatment-resistant depression]. ⬇️

scientific article published in December 2015

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