List of works - Daniel Watterson

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

scientific article

A Step-up Approach for Cell Therapy in Stroke: Translational Hurdles of Bone Marrow-Derived Stem Cells.

scientific article published on 18 November 2011

A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase

scientific article

A knowledge-based system for cassette mutagenesis experimental design.

scientific article published in January 1988

A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation

scientific article

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

scientific article published on 4 September 2007

A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.

scientific article

A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns

scientific article published in November 2007

Affinity chromatography purification of a cyclic nucleotide phosphodiesterase using immobilized modulator protein, a troponin C-like protein from brain ⬇️

scientific article published on November 8, 1976

Amino acid sequence of the phosphorylation site of bovine cardiac myosin light chain

scientific article published on 01 May 1985

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

scientific article

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

scientific article published in November 2004

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury

scientific article

Analysis of differences between coomassie blue stain and silver stain procedures in polyacrylamide gels: conditions for the detection of calmodulin and troponin C.

scientific article published in June 1983

Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties

scientific article

Application of NMR spectroscopy in medicinal chemistry and drug discovery

scientific article

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis

scientific article

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

scientific article published on 10 April 2015

Chemical synthesis and expression of a calmodulin gene designed for site-specific mutagenesis

scientific article published in September 1985

Cloning, expression, and properties of the microtubule-stabilizing protein STOP

scientific article

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

scientific article published on April 2015

Comparative biochemistry of calmodulins and calmodulin-like proteins

scientific article published on 01 January 1980

Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction"

scientific article published on 16 July 2020

Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration

scientific article

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

scientific article

DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury

scientific journal article

De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders

scientific article published on July 2006

Death-associated protein kinase as a potential therapeutic target

scientific article

Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis

scientific article published on November 2006

Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function

scientific article published on 29 July 2005

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

scientific article

Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: a lead compound that attenuates vascular leak.

scientific article published on 11 August 2006

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

scientific article published on 17 October 2006

Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound

scientific article published in January 2002

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's

scientific article published on January 2003

Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins

scientific article

Drug-protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin

scientific article published in January 1985

Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.

scientific article published on 06 September 2009

Elucidation of a minimal immunoreactive site of vertebrate calmodulin

scientific article published on 01 December 1983

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

scientific article published on 6 June 2009

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid

scientific article published in August 2005

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

scientific article

Fluorescence characterization of VU-9 calmodulin, an engineered calmodulin with one tryptophan in calcium binding domain III.

scientific article

Gain of function mutations for yeast calmodulin and calcium dependent regulation of protein kinase activity.

scientific article

Generation and behavior characterization of CaMKIIβ knockout mice

scientific article

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

scientific article published in January 2006

Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches

scientific article published on January 2007

Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation

scientific article

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter

scientific article

Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch protein

scientific article published on 01 June 1999

Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase

scientific article (publication date: 2013)

Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis.

scientific article published on 30 August 2007

Interaction of smooth muscle caldesmon with calmodulin mutants

scientific article published on 01 February 1995

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid

scientific article

Isolation and characterization of calmodulin from the motile green alga Chlamydomonas reinhardtii

scientific article published on 01 February 1984

Isolation of a protein from brain using calcium-dependent affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates

scientific article published on 01 January 1980

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

scientific article

MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice

scientific article published on 16 February 2007

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses

scientific article published on 12 February 2016

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

scientific article

Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB.

scientific article published in September 2001

Mechanism of interleukin-1β induced-increase in mouse intestinal permeability in vivo

scientific article

Metabolically 35S-labeled recombinant calmodulin as a ligand for the detection of calmodulin-binding proteins.

scientific article

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

scientific article

Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures

scientific article

Multiple gene products are produced from a novel protein kinase transcription region.

scientific article published on October 1995

Mutation of Lys-75 affects calmodulin conformation

scientific article

Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes

scientific article published on 01 July 2006

Neuroinflammation: a potential therapeutic target

scientific article

Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.

scientific article

Optimizing the use of CROs by academia and small companies

scientific article published in July 2013

Phosphorylation Regulates Interaction of 210-kDa Myosin Light Chain Kinase N-terminal Domain with Actin Cytoskeleton.

scientific article

Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles

scientific article published in January 2001

Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice.

scientific article published on February 2007

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

scientific article

Rapid separation and quantitation of 3',5'-cyclic nucleotides and 5'-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography

scientific article published on 01 March 1980

Replacement of Lys-75 of calmodulin affects its interaction with smooth muscle caldesmon

scientific article

Reproducible production and characterization of anti-calmodulin antisera

scientific article published on 01 January 1980

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology.

scientific article published on 15 December 2016

Sequence alignment of calmodulin domains by metric analysis

scientific article published on 01 January 1980

Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands

scientific article published on 01 November 2001

Site-directed mutagenesis of the glycine-rich loop of death associated protein kinase (DAPK) identifies it as a key structure for catalytic activity

scientific article

Sites of interaction between kinase-related protein and smooth muscle myosin.

scientific article

Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon.

scientific article published in January 2002

Structural and functional properties of calmodulin from the eukaryotic microorganism Dictyostelium discoideum

scientific article published in June 1984

Structural characterization of the calcium binding protein s100 from adipose tissue

scientific article published in August 1985

Structural insight into nucleotide recognition by human death-associated protein kinase

scientific article

Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death

scientific article

Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase

scientific article published on 01 May 1999

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

scientific article

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

scientific article

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

scientific article

Targeting protein kinases in central nervous system disorders

scientific article

The 6th drug discovery for neurodegeneration conference: an intensive course on translating research into drugs.

scientific article published on 23 October 2012

The heterodimer calmodulin: myosin light-chain kinase as a prototype vertebrate calcium signal transduction complex

scientific article published on 01 November 1992

The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target

scientific article

Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton

scientific article

Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model

scientific article

List of works by Daniel Watterson

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

A Step-up Approach for Cell Therapy in Stroke: Translational Hurdles of Bone Marrow-Derived Stem Cells.

A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase

A knowledge-based system for cassette mutagenesis experimental design.

A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.

A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns

Affinity chromatography purification of a cyclic nucleotide phosphodiesterase using immobilized modulator protein, a troponin C-like protein from brain ⬇️

Amino acid sequence of the phosphorylation site of bovine cardiac myosin light chain

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury

Analysis of differences between coomassie blue stain and silver stain procedures in polyacrylamide gels: conditions for the detection of calmodulin and troponin C.

Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties

Application of NMR spectroscopy in medicinal chemistry and drug discovery

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

Chemical synthesis and expression of a calmodulin gene designed for site-specific mutagenesis

Cloning, expression, and properties of the microtubule-stabilizing protein STOP

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

Comparative biochemistry of calmodulins and calmodulin-like proteins

Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction"

Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury

De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders

Death-associated protein kinase as a potential therapeutic target

Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis

Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: a lead compound that attenuates vascular leak.

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's

Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins

Drug-protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin

Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.

Elucidation of a minimal immunoreactive site of vertebrate calmodulin

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

Fluorescence characterization of VU-9 calmodulin, an engineered calmodulin with one tryptophan in calcium binding domain III.

Gain of function mutations for yeast calmodulin and calcium dependent regulation of protein kinase activity.

Generation and behavior characterization of CaMKIIβ knockout mice

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches

Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter

Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch protein

Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase

Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis.

Interaction of smooth muscle caldesmon with calmodulin mutants

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid

Isolation and characterization of calmodulin from the motile green alga Chlamydomonas reinhardtii

Isolation of a protein from brain using calcium-dependent affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB.

Mechanism of interleukin-1β induced-increase in mouse intestinal permeability in vivo

Metabolically 35S-labeled recombinant calmodulin as a ligand for the detection of calmodulin-binding proteins.

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures

Multiple gene products are produced from a novel protein kinase transcription region.

Mutation of Lys-75 affects calmodulin conformation

Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes

Neuroinflammation: a potential therapeutic target

Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.

Optimizing the use of CROs by academia and small companies

Phosphorylation Regulates Interaction of 210-kDa Myosin Light Chain Kinase N-terminal Domain with Actin Cytoskeleton.

Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles

Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice.

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

Rapid separation and quantitation of 3',5'-cyclic nucleotides and 5'-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography

Replacement of Lys-75 of calmodulin affects its interaction with smooth muscle caldesmon

Reproducible production and characterization of anti-calmodulin antisera

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology.