List of works - Alexis-Pierre Bemelmans

A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina

scientific article

A Single Cisterna Magna Injection of AAV Leads to Binaural Transduction in Mice

scientific article published on 01 January 2021

A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

scientific article published on 30 October 2019

A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina

scientific article

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

scientific article

An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity

scientific article published in January 1996

Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration

scientific article

Author Correction: TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

scientific article published in Nature Communications

BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge

scientific article

Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer

scientific article published in December 1999

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

scientific article

Connexin 30 controls astroglial polarization during postnatal brain development.

scientific article published on 23 February 2018

Cover Image, Volume 113, Number 12, December 2016.

scientific article published on December 2016

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

scientific article published on 8 October 2015

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing

scientific article published on 20 October 2021

Efficient lentiviral gene transfer into corneal stroma cells using a femtosecond laser

scientific article

Evaluation of tolerance to lentiviral LV-RPE65 gene therapy vector after subretinal delivery in nonhuman primates.

scientific article

Fast calcium transients in dendritic spines driven by extreme statistics

scientific article published on 04 June 2019

Functional reinnervation from remaining DA terminals induced by GDNF lentivirus in a rat model of early Parkinson's disease.

scientific article

Gene therapy of the central nervous system: general considerations on viral vectors for gene transfer into the brain.

scientific article

Gene therapy regenerates protein expression in cone photoreceptors in Rpe65(R91W/R91W) mice

scientific article

Grafts of brain-derived neurotrophic factor and neurotrophin 3-transduced primate Schwann cells lead to functional recovery of the demyelinated mouse spinal cord.

scientific article

Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability

scientific article published on 29 August 2013

IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats

scientific article

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

scientific article published on 01 March 2020

Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8.

scientific article published on 4 June 2016

Insulin growth factor-1 protects against excitotoxicity in the rat striatum

scientific article published in October 2004

Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis

scientific article

Lentiviral gene transfer-mediated cone vision restoration in RPE65 knockout mice

scientific article published in January 2008

Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA.

scientific article published in January 2006

Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge

scientific article

Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning

scientific article published on 01 August 2020

Loss of Otx2 in the adult retina disrupts retinal pigment epithelium function, causing photoreceptor degeneration

scientific article published on June 2013

Mammalian vesicular glutamate transporter VGLUT1 reduces synaptic vesicle superpool size and spontaneous release frequency

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease

scientific article published on 16 October 2018

Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy

scientific article published on 10 April 2019

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

scientific article published in July 2005

Physiological synaptic activity and recognition memory require astroglial glutamine

scientific article published on 08 February 2022

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.

scientific article published on 14 December 2017

Progenitors from the central nervous system drive neurogenesis in cancer

scientific article published on 15 May 2019

Publisher Correction: Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy

scientific article published on 09 May 2019

Publisher Correction: Progenitors from the central nervous system drive neurogenesis in cancer

scientific article published on 01 January 2020

Remaining rod activity mediates visual behavior in adult Rpe65-/- mice.

scientific article published on 11 August 2010

Repair of rhodopsin mRNA by spliceosome-mediated RNA trans-splicing: a new approach for autosomal dominant retinitis pigmentosa

scientific article published on 26 January 2015

Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter.

scientific article published in October 2005

Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histology

scientific article

Structural and functional connections between the median and the ventrolateral preoptic nucleus

scientific article published on 06 September 2019

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons.

scientific article

Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors

scientific article

Taurine provides neuroprotection against retinal ganglion cell degeneration

scientific article

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

scientific article published on 09 October 2019

The intellectual disability protein Oligophrenin-1 controls astrocyte morphology and migration

scientific article published on 19 February 2020

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

scientific article published on 9 March 2018

Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

scientific article (publication date: 2016)

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.

scientific article published on 4 November 2015

mRNA trans-splicing in gene therapy for genetic diseases

scientific article

rAAV-Mediated Cochlear Gene Therapy: Prospects and Challenges for Clinical Application

scientific article published on 21 February 2020

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.

scientific article

List of works by Alexis-Pierre Bemelmans

A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina

A Single Cisterna Magna Injection of AAV Leads to Binaural Transduction in Mice

A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity

Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration

Author Correction: TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge

Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

Connexin 30 controls astroglial polarization during postnatal brain development.

Cover Image, Volume 113, Number 12, December 2016.

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing

Efficient lentiviral gene transfer into corneal stroma cells using a femtosecond laser

Evaluation of tolerance to lentiviral LV-RPE65 gene therapy vector after subretinal delivery in nonhuman primates.

Fast calcium transients in dendritic spines driven by extreme statistics

Functional reinnervation from remaining DA terminals induced by GDNF lentivirus in a rat model of early Parkinson's disease.

Gene therapy of the central nervous system: general considerations on viral vectors for gene transfer into the brain.

Gene therapy regenerates protein expression in cone photoreceptors in Rpe65(R91W/R91W) mice

Grafts of brain-derived neurotrophic factor and neurotrophin 3-transduced primate Schwann cells lead to functional recovery of the demyelinated mouse spinal cord.

Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability

IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8.

Insulin growth factor-1 protects against excitotoxicity in the rat striatum

Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis

Lentiviral gene transfer-mediated cone vision restoration in RPE65 knockout mice

Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA.

Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge

Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning

Loss of Otx2 in the adult retina disrupts retinal pigment epithelium function, causing photoreceptor degeneration

Mammalian vesicular glutamate transporter VGLUT1 reduces synaptic vesicle superpool size and spontaneous release frequency

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease

Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

Physiological synaptic activity and recognition memory require astroglial glutamine

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.

Progenitors from the central nervous system drive neurogenesis in cancer

Publisher Correction: Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy

Publisher Correction: Progenitors from the central nervous system drive neurogenesis in cancer

Remaining rod activity mediates visual behavior in adult Rpe65-/- mice.

Repair of rhodopsin mRNA by spliceosome-mediated RNA trans-splicing: a new approach for autosomal dominant retinitis pigmentosa

Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter.

Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histology

Structural and functional connections between the median and the ventrolateral preoptic nucleus

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons.

Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors

Taurine provides neuroprotection against retinal ganglion cell degeneration

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

The intellectual disability protein Oligophrenin-1 controls astrocyte morphology and migration

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.

mRNA trans-splicing in gene therapy for genetic diseases

rAAV-Mediated Cochlear Gene Therapy: Prospects and Challenges for Clinical Application

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.