List of works - Andrew Harkin

A role for serotonin in the antidepressant activity of NG-Nitro-L-arginine, in the rat forced swimming test.

scientific article published on 26 November 2009

A study of VitalView for behavioural and physiological monitoring in laboratory rats.

scientific article published on September 2002

A toxicokinetic study of nickel-induced immunosuppression in rats

scientific article published in November 2003

Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression.

scientific article

Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1 beta independent of a catecholamine-driven increase in IL-10 production

scientific article published on 8 December 2004

Adenosine A1 receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination

scientific article published in December 2004

C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy.

scientific article published on 6 August 2013

Caffeine induces a profound and persistent tachycardia in response to MDMA ("Ecstasy") administration

scientific article published on 03 November 2006

Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").

scientific article

Caffeine provokes adverse interactions with 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) and related psychostimulants: mechanisms and mediators ⬇️

scientific article published on November 1, 2012

Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression

scientific article published on 28 May 2014

Characterization of d-fenfluramine-induced hypothermia: evidence for multiple sites of action

article

Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat.

scientific article

Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats

scientific article published on 26 February 2016

Corrigendum to: “Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors” [Eur. J. Pharmacol. 389 (2000) 187–192]

scientific article published on 01 June 2000

DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic–pituitary–adrenal axis activity and to early life emotional abuse

article

Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder.

scientific article published on 24 October 2017

Dopamine D1 receptor-mediated intracellular responses in the hypothalamus after co-administration of caffeine with MDMA.

scientific article

Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test

scientific article published on 01 April 2000

Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity

scientific article published on 01 January 1999

Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression

scientific article published on 10 March 2014

Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder

scientific article

Glial fibrillary acidic protein (GFAP) immunoreactivity correlates with cortical perfusion parameters determined by bolus tracking arterial spin labelling (bt-ASL) magnetic resonance (MR) imaging in the Wistar Kyoto rat.

scientific article

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?

scientific article published on 7 June 2008

Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour

scientific article published on 29 January 2014

Investigation of the mechanisms mediating MDMA "Ecstasy"-induced increases in cerebro-cortical perfusion determined by btASL MRI.

scientific article published in November 2014

Ketamine and depression: A special kase for kynurenic acid?

Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism.

scientific article published on 2 March 2013

L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents

scientific article published on 09 January 2019

L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats

scientific article published on 29 March 2019

Lipids and essential fatty acids in patients presenting with self-harm

scientific article published on 01 February 2007

MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI

scientific article published on July 2013

Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor necrosis factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10.

scientific article

Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin

scientific article

Methylenendioxyamphetamine produces serotonin nerve terminal loss and diminished behavioural and neurochemical responses to the antidepressant fluoxetine

scientific article published in August 2003

Metyrapone displays antidepressant-like properties in preclinical paradigms.

scientific article

Modulation of MK-801-induced behaviour by noradrenergic agents in mice

scientific article published in March 2001

Muscling in on depression

scientific article

Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test

scientific article

Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test

scientific article published on 01 May 1999

Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex

scientific article published on 31 March 2010

Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration.

scientific article published in March 2010

Noradrenaline acting on astrocytic β₂-adrenoceptors induces neurite outgrowth in primary cortical neurons

scientific article published on 12 October 2013

Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.

scientific article published on 12 January 2010

Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration

scientific article

Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors

scientific article published on 01 February 2000

Olfactory bulbectomy in mice induces alterations in exploratory behavior

scientific article published in February 2005

Pharmacological targeting of β2 -adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson's disease

scientific article published on 12 December 2019

Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression

scientific article published on 29 November 2012

Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats

scientific article

Reboxetine attenuates forced swim test-induced behavioural and neurochemical alterations in the rat.

scientific article

Reduced efficacy of fluoxetine following MDMA ("Ecstasy")-induced serotonin loss in rats

scientific article published on 13 September 2008

Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity

scientific article published on 26 August 2016

Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors

scientific article published in April 2003

Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice.

scientific article published on 27 February 2013

Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons

scientific article

Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1.

scientific article

Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB.

scientific article published on 26 July 2013

Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders.

scientific article published on 12 December 2015

The PSD-95/nNOS complex: new drugs for depression?

scientific article

The functional sensitisation of sigma receptors following chronic selective serotonin reuptake inhibitor treatment

scientific article published in April 1998

The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes ⬇️

scientific article published on 08 August 2012

The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity.

scientific article published on 3 July 2010

Treatment with the noradrenaline re-uptake inhibitor atomoxetine alone and in combination with the α2-adrenoceptor antagonist idazoxan attenuates loss of dopamine and associated motor deficits in the LPS inflammatory rat model of Parkinson's disease

scientific article published on 12 January 2018

Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation

scientific article published on 6 June 2012

Varying responses to the rat forced-swim test under diurnal and nocturnal conditions

scientific article published on 01 June 2000

List of works by Andrew Harkin

A role for serotonin in the antidepressant activity of NG-Nitro-L-arginine, in the rat forced swimming test.

A study of VitalView for behavioural and physiological monitoring in laboratory rats.

A toxicokinetic study of nickel-induced immunosuppression in rats

Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression.

Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1 beta independent of a catecholamine-driven increase in IL-10 production

Adenosine A1 receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination

C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy.

Caffeine induces a profound and persistent tachycardia in response to MDMA ("Ecstasy") administration

Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").

Caffeine provokes adverse interactions with 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) and related psychostimulants: mechanisms and mediators ⬇️

Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression

Characterization of d-fenfluramine-induced hypothermia: evidence for multiple sites of action

Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat.

Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats

Corrigendum to: “Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors” [Eur. J. Pharmacol. 389 (2000) 187–192]

DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic–pituitary–adrenal axis activity and to early life emotional abuse

Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder.

Dopamine D1 receptor-mediated intracellular responses in the hypothalamus after co-administration of caffeine with MDMA.

Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test

Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity

Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression

Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder

Glial fibrillary acidic protein (GFAP) immunoreactivity correlates with cortical perfusion parameters determined by bolus tracking arterial spin labelling (bt-ASL) magnetic resonance (MR) imaging in the Wistar Kyoto rat.

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?

Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour

Investigation of the mechanisms mediating MDMA "Ecstasy"-induced increases in cerebro-cortical perfusion determined by btASL MRI.

Ketamine and depression: A special kase for kynurenic acid?

Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism.

L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents

L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats

Lipids and essential fatty acids in patients presenting with self-harm

MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI

Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor necrosis factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10.

Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin

Methylenendioxyamphetamine produces serotonin nerve terminal loss and diminished behavioural and neurochemical responses to the antidepressant fluoxetine

Metyrapone displays antidepressant-like properties in preclinical paradigms.

Modulation of MK-801-induced behaviour by noradrenergic agents in mice

Muscling in on depression

Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test

Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test

Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex

Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration.

Noradrenaline acting on astrocytic β₂-adrenoceptors induces neurite outgrowth in primary cortical neurons

Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.

Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration

Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors

Olfactory bulbectomy in mice induces alterations in exploratory behavior

Pharmacological targeting of β2 -adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson's disease

Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression

Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats

Reboxetine attenuates forced swim test-induced behavioural and neurochemical alterations in the rat.

Reduced efficacy of fluoxetine following MDMA ("Ecstasy")-induced serotonin loss in rats

Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity

Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors

Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice.

Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons

Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1.

Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB.

Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders.

The PSD-95/nNOS complex: new drugs for depression?

The functional sensitisation of sigma receptors following chronic selective serotonin reuptake inhibitor treatment

The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes ⬇️

The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity.

Treatment with the noradrenaline re-uptake inhibitor atomoxetine alone and in combination with the α2-adrenoceptor antagonist idazoxan attenuates loss of dopamine and associated motor deficits in the LPS inflammatory rat model of Parkinson's disease

Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation

Varying responses to the rat forced-swim test under diurnal and nocturnal conditions