List of works - Colin Adrain

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

scientific article

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

scientific article

Apoptosis: calling time on apoptosome activity

scientific article published on 6 October 2009

Apoptosomes: protease activation platforms to die from

scientific article

Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival

scientific article

CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways

scientific article

CELL BIOLOGY: Double Knockout Blow for Caspases

scientific article published in Science

Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man.

scientific article published on 21 June 2004

Caspases: Agents of Defense and Destruction

Defying death: showing Bcl-2 the way home

scientific article

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

scientific article published on 31 October 2019

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

scientific article published on 31 October 2000

Human and murine granzyme B exhibit divergent substrate preferences

scientific article

Inactive rhomboid proteins: New mechanisms with implications in health and disease.

scientific article

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

scientific article

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.

scientific article published on 23 August 2013

Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

scientific article

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.

scientific article published on 11 July 2012

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

scientific article published in October 2017

Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex

scientific article

Proteases, proteasomes and apoptosis: breaking Ub is hard to do.

scientific article published in September 2005

Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery.

scientific article published on 7 December 2017

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.

scientific article published on 4 August 2017

Regulation of receptor tyrosine kinase ligand processing

scientific article published on January 2014

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

scientific article

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

scientific article published on 06 June 2016

Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

scientific article published on March 2006

Search for Drosophila caspases bears fruit: STRICA enters the fray

scientific article published in April 2001

The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C

scientific article published on March 2003

The complex life of rhomboid pseudoproteases

scientific article published on 07 September 2020

The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics

scientific article published on 16 January 2006

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

scientific article

iRhom2 and TNF: Partners or enemies?

scientific article published on 29 October 2019

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

scientific article published on 13 June 2018

List of works by Colin Adrain

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

Apoptosis: calling time on apoptosome activity

Apoptosomes: protease activation platforms to die from

Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival

CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways

CELL BIOLOGY: Double Knockout Blow for Caspases

Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man.

Caspases: Agents of Defense and Destruction

Defying death: showing Bcl-2 the way home

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

Human and murine granzyme B exhibit divergent substrate preferences

Inactive rhomboid proteins: New mechanisms with implications in health and disease.

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.

Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex

Proteases, proteasomes and apoptosis: breaking Ub is hard to do.

Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery.

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.

Regulation of receptor tyrosine kinase ligand processing

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

Search for Drosophila caspases bears fruit: STRICA enters the fray

The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C

The complex life of rhomboid pseudoproteases

The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

iRhom2 and TNF: Partners or enemies?

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.