List of works - Romolo Nonno

1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues

scientific article published in June 1997

2-[125I]iodomelatonin binding sites in the bovine hippocampus are not sensitive to guanine nucleotides

scientific article published on 01 July 1995

2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

scientific article published on September 1998

A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models

scientific article published on 07 March 2019

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

scientific article published on 15 March 2016

A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties.

scientific article

A new method for the characterization of strain-specific conformational stability of protease-sensitive and protease-resistant PrPSc

scientific article

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

scientific article published on 07 August 2017

Animal Transmissible Spongiform Encephalopathies and Genetics

article

Assessment of the genetic susceptibility of sheep to scrapie by protein misfolding cyclic amplification and comparison with experimental scrapie transmission studies

scientific article published on 15 June 2011

Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature.

scientific article published on 23 November 2017

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains

scientific article

Biochemical characterization of prion strains in bank voles

scientific article

Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains

scientific article published on 08 January 2020

Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases

scientific article

Co-existence of classical scrapie and Nor98 in a sheep from an Italian outbreak

scientific article published on 23 December 2009

Cofactors influence the biological properties of infectious recombinant prions.

scientific article published in November 2017

Comparative performance of three TSE rapid tests for surveillance in healthy sheep affected by scrapie

scientific article published on 21 January 2011

Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study

scientific article published in June 1997

Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo

scientific article

Correlation between infectivity and disease associated prion protein in the nervous system and selected edible tissues of naturally affected scrapie sheep

scientific article

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

scientific article published on 23 October 2019

Diagnosis and PrP genotype target of scrapie in clinically healthy sheep of Massese breed in the framework of a scrapie eradication programme.

scientific article

Distribution and characterization of the melatonin receptors in the hypothalamus and pituitary gland of three domestic ungulates

scientific article published on 01 May 1995

EU-approved rapid tests might underestimate bovine spongiform encephalopathy infection in goats.

scientific article published on January 2017

Early behavioural changes in mice infected with BSE and scrapie: automated home cage monitoring reveals prion strain differences

scientific article published on August 2002

Efficient transmission and characterization of Creutzfeldt-Jakob disease strains in bank voles

scientific article

Further characterisation of transmissible spongiform encephalopathy phenotypes after inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain

scientific article

Genetic and Pathological Follow-Up Study of Goats Experimentally and Naturally Exposed to a Sheep Scrapie Isolate.

scientific article

Gerstmann-Sträussler-Scheinker disease subtypes efficiently transmit in bank voles as genuine prion diseases

scientific article

Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.

scientific article

Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie

article

In vitro replication highlights the mutability of prions

scientific article published on 01 January 2014

Intracerebral administration of interleukin-12 (IL-12) and IL-18 modifies the course of mouse scrapie

scientific article

Isolation of a Defective Prion Mutant from Natural Scrapie

scientific article

L-type bovine spongiform encephalopathy in genetically susceptible and resistant sheep: changes in prion strain or phenotypic plasticity of the disease-associated prion protein?

scientific article published on 11 November 2013

Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists

scientific article

Magnetic fields produced by power lines do not affect growth, serum melatonin, leukocytes and fledging success in wild kestrels.

scientific article

Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study

scientific article published in September 1998

Methods for the evaluation of drug action at the human melatonin receptor subtypes.

scientific article

Molecular analysis of cases of Italian sheep scrapie and comparison with cases of bovine spongiform encephalopathy (BSE) and experimental BSE in sheep

scientific article published in September 2003

Molecular discrimination of sheep bovine spongiform encephalopathy from scrapie

scientific article published on April 2011

Neurochemistry of myenteric plexus neurons of bank vole (Myodes glareolus) ileum.

scientific article

Nor98-like sheep scrapie in the United Kingdom in 1989.

scientific article published in May 2007

Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

scientific article published on 01 December 2018

Novel prion protein conformation and glycotype in Creutzfeldt-Jakob disease

scientific article

Oral pravastatin prolongs survival time of scrapie-infected mice

scientific article published on 12 March 2009

PRNP genetic variability and molecular typing of natural goat scrapie isolates in a high number of infected flocks

scientific article

Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells ⬇️

scientific article published on June 1, 1998

PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report

scientific article published in October 2001

PrPC Governs Susceptibility to Prion Strains in Bank Vole, While Other Host Factors Modulate Strain Features.

scientific article

PrPSc in salivary glands of scrapie-affected sheep

scientific article published on 14 February 2007

Prion Disease in Dromedary Camels, Algeria.

scientific article published on 17 June 2018

Prion Strain Characterization of a Novel Subtype of Creutzfeldt-Jakob Disease.

scientific article

Prion disease tempo determined by host-dependent substrate reduction

scientific article published on 16 January 2014

Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy

scientific article published on 18 April 2007

Prion protein amino acid determinants of differential susceptibility and molecular feature of prion strains in mice and voles

scientific article

Protective effect of the AT137RQ and ARQK176 PrP allele against classical scrapie in Sarda breed sheep.

scientific article published on 27 January 2009

Quantitative profiling of the pathological prion protein allotypes in bank voles by liquid chromatography-mass spectrometry.

scientific article

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

scientific article published on 31 January 2018

Small ruminant nor98 prions share biochemical features with human gerstmann-sträussler-scheinker disease and variably protease-sensitive prionopathy

scientific article (publication date: 2013)

Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America

scientific article published on 23 November 2020

Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

scientific article published on April 2001

The bank vole (Myodes glareolus) as a sensitive bioassay for sheep scrapie

scientific article

The melatonin receptor in the human brain: cloning experiments and distribution studies

scientific article published on 01 July 1996

The mouse model for scrapie: inoculation, clinical scoring, and histopathological techniques

scientific article published on 01 January 2012

Transmissibility of Gerstmann-Sträussler-Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity.

scientific article published on 28 November 2016

Ultra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technology

scientific article

Variable Protease-Sensitive Prionopathy Transmission to Bank Voles

article

List of works by Romolo Nonno

1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues

2-[125I]iodomelatonin binding sites in the bovine hippocampus are not sensitive to guanine nucleotides

2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties.

A new method for the characterization of strain-specific conformational stability of protease-sensitive and protease-resistant PrPSc

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

Animal Transmissible Spongiform Encephalopathies and Genetics

Assessment of the genetic susceptibility of sheep to scrapie by protein misfolding cyclic amplification and comparison with experimental scrapie transmission studies

Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature.

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains

Biochemical characterization of prion strains in bank voles

Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains

Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases

Co-existence of classical scrapie and Nor98 in a sheep from an Italian outbreak

Cofactors influence the biological properties of infectious recombinant prions.

Comparative performance of three TSE rapid tests for surveillance in healthy sheep affected by scrapie

Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study

Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo

Correlation between infectivity and disease associated prion protein in the nervous system and selected edible tissues of naturally affected scrapie sheep

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

Diagnosis and PrP genotype target of scrapie in clinically healthy sheep of Massese breed in the framework of a scrapie eradication programme.

Distribution and characterization of the melatonin receptors in the hypothalamus and pituitary gland of three domestic ungulates

EU-approved rapid tests might underestimate bovine spongiform encephalopathy infection in goats.

Early behavioural changes in mice infected with BSE and scrapie: automated home cage monitoring reveals prion strain differences

Efficient transmission and characterization of Creutzfeldt-Jakob disease strains in bank voles

Further characterisation of transmissible spongiform encephalopathy phenotypes after inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain

Genetic and Pathological Follow-Up Study of Goats Experimentally and Naturally Exposed to a Sheep Scrapie Isolate.

Gerstmann-Sträussler-Scheinker disease subtypes efficiently transmit in bank voles as genuine prion diseases

Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.

Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie

In vitro replication highlights the mutability of prions

Intracerebral administration of interleukin-12 (IL-12) and IL-18 modifies the course of mouse scrapie

Isolation of a Defective Prion Mutant from Natural Scrapie

L-type bovine spongiform encephalopathy in genetically susceptible and resistant sheep: changes in prion strain or phenotypic plasticity of the disease-associated prion protein?

Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists

Magnetic fields produced by power lines do not affect growth, serum melatonin, leukocytes and fledging success in wild kestrels.

Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study

Methods for the evaluation of drug action at the human melatonin receptor subtypes.

Molecular analysis of cases of Italian sheep scrapie and comparison with cases of bovine spongiform encephalopathy (BSE) and experimental BSE in sheep

Molecular discrimination of sheep bovine spongiform encephalopathy from scrapie

Neurochemistry of myenteric plexus neurons of bank vole (Myodes glareolus) ileum.

Nor98-like sheep scrapie in the United Kingdom in 1989.

Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

Novel prion protein conformation and glycotype in Creutzfeldt-Jakob disease

Oral pravastatin prolongs survival time of scrapie-infected mice

PRNP genetic variability and molecular typing of natural goat scrapie isolates in a high number of infected flocks

Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells ⬇️

PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report

PrPC Governs Susceptibility to Prion Strains in Bank Vole, While Other Host Factors Modulate Strain Features.

PrPSc in salivary glands of scrapie-affected sheep

Prion Disease in Dromedary Camels, Algeria.

Prion Strain Characterization of a Novel Subtype of Creutzfeldt-Jakob Disease.

Prion disease tempo determined by host-dependent substrate reduction

Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy

Prion protein amino acid determinants of differential susceptibility and molecular feature of prion strains in mice and voles

Protective effect of the AT137RQ and ARQK176 PrP allele against classical scrapie in Sarda breed sheep.

Quantitative profiling of the pathological prion protein allotypes in bank voles by liquid chromatography-mass spectrometry.

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

Small ruminant nor98 prions share biochemical features with human gerstmann-sträussler-scheinker disease and variably protease-sensitive prionopathy

Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America

Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

The bank vole (Myodes glareolus) as a sensitive bioassay for sheep scrapie

The melatonin receptor in the human brain: cloning experiments and distribution studies

The mouse model for scrapie: inoculation, clinical scoring, and histopathological techniques

Transmissibility of Gerstmann-Sträussler-Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity.

Ultra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technology

Variable Protease-Sensitive Prionopathy Transmission to Bank Voles