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List of works by Milena Soares

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

scientific article published on 24 November 2020

A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice

scientific article (publication date: June 2006)

A strategy for identifying serodiagnostically relevant antigens of Leishmania or other pathogens in genetic libraries.

scientific article

Activity of Physalin F in a Collagen-Induced Arthritis Model

article

Activity of antimalarial drugs in vitro and in a murine model of cutaneous leishmaniasis.

scientific article published on 28 March 2013

Activity of physalins purified from Physalis angulata in in vitro and in vivo models of cutaneous leishmaniasis. ⬇️

scientific article

Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy

scientific article published on 20 August 2013

Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice

scientific article

Alterations in pulmonary structure by elastase administration in a model of emphysema in mice is associated with functional disturbances

article

Anti-Trypanosoma cruzi activity of nicotinamide

scientific article

Anti-inflammatory properties of rose oxide

scientific article published on 01 November 2012

Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii

scientific article published on 04 July 2007

Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazole derivatives.

scientific article

Anticonvulsant activity of bone marrow cells in electroconvulsive seizures in mice

scientific article

Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model.

scientific article published on 09 August 2013

Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract

scientific article published on 12 June 2009

Antimalarial Activity of Physalins B, D, F, and G ⬇️

scientific article published on September 28, 2011

Antinociceptive Effect of Lupeol: Evidence for a Role of Cytokines Inhibition

article

Antinociceptive Properties of Bergenin

scientific article published on 22 September 2011

Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition

article

Antiparasitic activities of novel ruthenium/lapachol complexes.

scientific article published on 27 March 2014

Antiparasitic and immunomodulatory activities of 1,1-bis(4-hydroxyphenyl)-2-phenyl-but-1-ene and its protected and free 2-ferrocenyl derivatives

Antiparasitic evaluation of betulinic acid derivatives reveals effective and selective anti-Trypanosoma cruzi inhibitors

scientific article published on 11 April 2016

Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.

scientific article

Antitumor Properties of the leaf essential oil of Zornia brasiliensis.

scientific article published on 9 April 2015

Approaches for the development of new anti-Trypanosoma cruzi agents.

scientific article published on March 2009

Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease

scientific article

Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy.

scientific article published on 16 March 2017

Bioinformatics tools for screening of antiparasitic drugs.

scientific article published on March 2009

Biological studies and chromatograms aided by chemometric analysis in evaluation of seasonality and extraction method of Croton grewioides extracts

scientific article published in 2022

Bone marrow cell transplantation in Chagas' disease heart failure: report of the first human experience.

scientific article

Bone marrow cells migrate to the heart and skeletal muscle and participate in tissue repair after Trypanosoma cruzi infection in mice

scientific article

Bone marrow-derived cells migrate to the liver and contribute to the generation of different cell types in chronic Schistosoma mansoni infection

scientific article published on 18 August 2015

CALCITONIN GENE-RELATED PEPTIDE INHIBITS LOCAL ACUTE INFLAMMATION AND PROTECTS MICE AGAINST LETHAL ENDOTOXEMIA

article

Caffeoylquinic acids from antiplasmodial active extract of Xanthium cavanillesii fruits and their molecular modelling studies

scientific article published on 13 August 2016

Caspase inhibition reduces lymphocyte apoptosis and improves host immune responses to Trypanosoma cruzi infection

article

Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.

scientific article published on May 2007

Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells

scientific article published on 14 September 2020

Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection

scientific article published on 18 September 2006

Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice

Chemical composition of essential oils fromAnnona vepretorumMart. andAnnona squamosaL. (Annonaceae) leaves and their antimalarial and trypanocidal activities

article

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

scientific article published on 21 July 2016

Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease

scientific article

Conditioned Medium of Bone Marrow-Derived Mesenchymal Stromal Cells as a Therapeutic Approach to Neuropathic Pain: A Preclinical Evaluation.

scientific article published on 30 January 2018

Current status of stem cell therapy for liver diseases

scientific article published on 05 August 2009

Cyperus articulatus L. (Cyperaceae) Rhizome Essential Oil Causes Cell Cycle Arrest in the G2/M Phase and Cell Death in HepG2 Cells and Inhibits the Development of Tumors in a Xenograft Model

scientific article published on 09 June 2020

Cytotoxic Alkaloids from the Stem of Xylopia laevigata. ⬇️

scientific article published on 8 July 2016

Cytotoxic and Antifungal Amides Derived from Ferulic Acid: Molecular Docking and Mechanism of Action

scientific article published on 01 November 2021

Cytotoxic effect of leaf essential oil of Lippia gracilis Schauer (Verbenaceae).

scientific article published on 28 February 2013

Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni

scientific article published on 30 March 2004

Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents

scientific article published on 24 January 2014

Design, synthesis and structure–activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities

scientific article published on 20 April 2015

Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity ⬇️

scientific article

Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice.

scientific article published in August 2010

Down-regulation of CXCR2 on Neutrophils in Severe Sepsis Is Mediated by Inducible Nitric Oxide Synthase–derived Nitric Oxide

scientific article published on 30 November 2006

Early toxicity screening and selection of lead compounds for parasitic diseases

scientific article published on March 2009

Early transplantation of bone marrow mononuclear cells promotes neuroprotection and modulation of inflammation after status epilepticus in mice by paracrine mechanisms

scientific article published on 17 December 2013

Editorial [Hot Topic: Approaches for Development of New Antiprotozoan Drugs(Guest Editor: Milena B.P. Soares)]

article

Effects of umbelliferone in a murine model of allergic airway inflammation

scientific article published on 14 March 2009

Endogenous Interleukin-4 Downregulates the Type 1 CD4 T Cell-Mediated Immune Response Induced by Intramuscular DNA Immunization

scientific article published on 01 November 2002

Evaluation of Galectin-3 as a Novel Biomarker for Chagas Cardiomyopathy

scientific article

Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent.

scientific article published on 28 November 2014

Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate

scientific article published on 25 February 2013

Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.

scientific article

Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice

Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens

scientific article published in March 2002

GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells

scientific article published on 24 August 2020

Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy

scientific article

Gap junctions and chagas disease

scientific article published on January 2011

Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy

scientific article

Generation and characterization of transgenic mouse mesenchymal stem cell lines expressing hIGF-1 or hG-CSF.

scientific article published on 2 September 2017

Genetic vaccination against experimental infection with myotropic parasite strains of Trypanosoma cruzi

scientific article

Genomic databases and the search of protein targets for protozoan parasites.

scientific article published on March 2009

Genotoxicity and antileishmanial activity evaluation of Physalis angulata concentrated ethanolic extract

scientific article

Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function

scientific article published on 16 July 2009

Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy

scientific article published on 4 November 2005

Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection

article

IGF-1-Overexpressing Mesenchymal Stem/Stromal Cells Promote Immunomodulatory and Proregenerative Effects in Chronic Experimental Chagas Disease

scientific article published on 24 July 2018

Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study

scientific article published on 28 July 2017

Immunization with cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi stimulates a cellular immune response in mice

scientific article published in November 2004

In silico and in vitro: identifying new drugs.

scientific article published on December 2008

In vitro and in vivo antiparasitic activity of Physalis angulata L. concentrated ethanolic extract against Trypanosoma cruzi

scientific article published on 29 July 2015

Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.

scientific article

Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. ⬇️

scientific article published in January 2003

Intramyocardial transplantation of cardiac mesenchymal stem cells reduces myocarditis in a model of chronic Chagas disease cardiomyopathy

scientific article

Invasive and noninvasive correlations of B-type natriuretic peptide in patients with heart failure due to Chagas cardiomyopathy

scientific article published in May 2008

Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni.

scientific article

Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin

scientific article published on 18 March 2011

Mechanisms of the anti-inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury.

scientific article published in September 2005

Mesenchymal and embryonic characteristics of stem cells obtained from mouse dental pulp

scientific article published on 16 June 2011

Nitro/nitrosyl-ruthenium complexes are potent and selective anti-Trypanosoma cruzi agents causing autophagy and necrotic parasite death

scientific article

Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice

scientific article published on 31 August 2012

Patenting bioactive molecules from biodiversity: the Brazilian experience

scientific article

Pharmacological Properties of Riparin IV in Models of Pain and Inflammation.

scientific article published on 21 December 2016

Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi

scientific article published on 11 January 2016

Physalin F, a seco-steroid from Physalis angulata L., has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy.

scientific article published on 19 February 2016

Physalins B and F, seco-steroids isolated from Physalis angulata L., strongly inhibit proliferation, ultrastructure and infectivity of Trypanosoma cruzi.

scientific article published on 4 September 2013

Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection.

scientific article published on 12 October 2005

Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia

scientific article published on October 2014

Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy

scientific article

Production of Highly Active Antiparasitic Compounds from the Controlled Halogenation of the Arrabidaea brachypoda Crude Plant Extract

scientific article published on 09 September 2020

Prolonged shedding of Chikungunya virus in semen and urine: A new perspective for diagnosis and implications for transmission

scientific article (publication date: 2016)

Protein-drug interaction studies for development of drugs against Plasmodium falciparum.

scientific article published on March 2009

Recovery of pulmonary structure and exercise capacity by treatment with granulocyte-colony stimulating factor (G-CSF) in a mouse model of emphysema

scientific article published on 17 April 2013

Reduction of galectin-3 expression and liver fibrosis after cell therapy in a mouse model of cirrhosis

scientific article

Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells

scientific article

Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.

scientific article published on 19 January 2006

Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury.

scientific article published on 17 November 2014

Selection of molecular targets for drug development against trypanosomatids

scientific article published on January 2014

Selection of targets for drug development against protozoan parasites.

scientific article published on March 2009

Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection.

scientific article

Structural Investigation of Anti-Trypanosoma cruzi 2-Iminothiazolidin-4-ones Allows the Identification of Agents with Efficacy in Infected Mice

scientific article published on 07 December 2012

Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi.

scientific article

Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-Trypanosoma cruzi activity.

scientific article

Structural improvement of new thiazolidinones compounds with antinociceptive activity in experimental chemotherapy-induced painful neuropathy

scientific article published on 23 January 2017

Structural insights of SIR2rp3 proteins as promising biotargets to fight against Chagas disease and leishmaniasis.

scientific article

Structure-activity relationships of mononuclear metal-thiosemicarbazone complexes endowed with potent antiplasmodial and antiamoebic activities.

scientific article published on 21 July 2010

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.

scientific article

Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi

scientific article published on 3 February 2006

The MHC gene region of murine hosts influences the differential tissue tropism of infecting Trypanosoma cruzi strains

scientific article

The anti-hyperalgesic and anti-inflammatory profiles of p-cymene: Evidence for the involvement of opioid system and cytokines

scientific article published on 9 April 2015

The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet ⬇️

scientific article published on December 1, 2001

The triterpenoid lupeol attenuates allergic airway inflammation in a murine model.

scientific article published on 27 May 2008

Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy

scientific article published on 21 July 2017

Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni.

scientific article published on October 2008

Therapy with mesenchymal stromal cells or conditioned medium reverse cardiac alterations in a high-fat diet-induced obesity model

scientific article published on 8 August 2017

Transplantation of adipose tissue mesenchymal stem cells in experimental chronic chagasic cardiopathy

scientific article published on 9 April 2013

Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood-brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease

scientific article

Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats

scientific article

Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice.

scientific article published on 8 April 2013

Transplantation of stem cells obtained from murine dental pulp improves pancreatic damage, renal function, and painful diabetic neuropathy in diabetic type 1 mouse model.

scientific article published on 12 October 2012

Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations

scientific article

Trypanosoma cruzi: requirements for induction and maintenance of protective immunity conferred by immunization

Use of autologous mesenchymal stem cells derived from bone marrow for the treatment of naturally injured spinal cord in dogs.

scientific article published on 25 February 2014

Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice

scientific article published on 8 September 2011

Xylopine Induces Oxidative Stress and Causes G2/M Phase Arrest, Triggering Caspase-Mediated Apoptosis by p53-Independent Pathway in HCT116 Cells

scientific article

ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation

scientific article

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