List of works - Gian Gaetano Tartaglia

A Computational Approach for the Discovery of Protein–RNA Networks

scientific article published on 01 January 2016

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

scientific article published on 16 June 2016

A Method for RNA Structure Prediction Shows Evidence for Structure in lncRNAs

article

A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

scientific article published in 2012

A high-throughput approach to profile RNA structure

scientific article published on 28 November 2016

A metastable subproteome underlies inclusion formation in muscle proteinopathies

scientific article published on 03 December 2019

A method for RNA structure prediction shows evidence for structure in lncRNAs

article

A relationship between mRNA expression levels and protein solubility in E. coli

scientific article published on 10 March 2009

ALMOST: an all atom molecular simulation toolkit for protein structure determination.

scientific article

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

scientific article published on 23 September 2011

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

scientific article

Advances in the characterization of RNA-binding proteins

scientific article

Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate

scientific article published on 15 May 2009

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

scientific article published on January 2011

An Integrative Study of Protein-RNA Condensates Identifies Scaffolding RNAs and Reveals Players in Fragile X-Associated Tremor/Ataxia Syndrome

scientific article published on 01 December 2018

Assembly of Proteins by Free RNA during the Early Phase of Proteostasis Stress

scientific article published on 18 June 2019

BacFITBase: a database to assess the relevance of bacterial genes during host infection

scientific article published on 01 January 2020

By the company they keep: interaction networks define the binding ability of transcription factors

scientific article published on 18 June 2015

CROSSalive: a web server for predicting the in vivo structure of RNA molecules

scientific article published on 01 February 2020

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins

article

Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin

scientific article (publication date: 2012)

Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin

scientific article published on 24 December 2008

Competition between intramolecular and intermolecular interactions in an amyloid-forming protein

scientific article published on 23 April 2009

Computational analysis of the S. cerevisiae proteome reveals the function and cellular localization of the least and most amyloidogenic proteins

article

Constitutive patterns of gene expression regulated by RNA-binding proteins

scientific article

Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisations

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

scientific article published on 18 February 2011

Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing

scientific article published on 15 July 2020

Discovering the 3' UTR-mediated regulation of alpha-synuclein

scientific article published on 15 November 2017

Discovery of protein-RNA networks

scientific article published on 23 April 2014

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

scientific article published on 10 June 2011

DnaK functions as a central hub in the E. coli chaperone network

scientific article published on 8 March 2012

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

article

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity

scientific article

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

scientific article published in April 2018

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells

scientific article published on 02 July 2019

Homage to Chris Dobson

scientific article published on 12 December 2019

Insights into the structure-driven protein interactivity of RNA molecules

Insights on protein thermal stability: a graph representation of molecular interactions

scientific article published on 22 June 2018

Insights on protein thermal stability: a graph representation of molecular interactions

scientific article published on 01 August 2019

Interactions in the native state of monellin, which play a protective role against aggregation

article

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide

scientific article

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

article

Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex

scientific article published on 04 February 2020

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

scientific article published on 01 July 2021

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

article

Modulation of human corticospinal excitability by paired associative stimulation in patients with amyotrophic lateral sclerosis and effects of Riluzole

scientific article published on 7 February 2018

Molecular Pathophysiology of Fragile X-Associated Tremor/Ataxia Syndrome and Perspectives for Drug Development.

scientific article

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

scientific article published in May 2008

Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase

scientific article published on 12 September 2008

Neurodegeneration and Cancer: Where the Disorder Prevails

scientific article published on 23 October 2015

Neurodegeneration as an RNA disorder ⬇️

scientific article published on October 10, 2012

Neurodegenerative diseases: quantitative predictions of protein-RNA interactions

scientific article published on 21 December 2012

Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma

scientific article published in August 2017

Nivolumab as a safe and effective treatment in an HIV patient with refractory Hodgkin lymphoma

article

Non-random distribution of homo-repeats: links with biological functions and human diseases

scientific article published on 03 June 2016

Organism complexity anti-correlates with proteomic beta-aggregation propensity

scientific article

Phase Separations Driven by RNA Scaffolds and Protein Sequestration in FXTAS

Phase separation drives X-chromosome inactivation: a hypothesis

scientific article published on 01 May 2019

Physicochemical Principles of Protein Aggregation

scientific article published on January 1, 2013

Physicochemical determinants of chaperone requirements

scientific article

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

scholarly article

Position-dependent electrostatic protection against protein aggregation

scientific article published in May 2009

Post-transcriptional regulatory patterns revealed by protein-RNA interactions

Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1

scientific article published on 06 May 2019

Predicting protein associations with long noncoding RNAs

scientific article published in June 2011

Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences

Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

scientific article

Prediction of aggregation-prone regions in structured proteins

scientific article published on 13 May 2008

Prediction of protein-RNA interactions from single-cell transcriptomic data

scientific article published in 2024

Predictions of protein-RNA interactions

article published in 2012

Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein

scientific article published on 03 September 2013

Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation

scientific article published on 01 December 2018

Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets

scientific article published on 16 December 2015

Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs

scientific article published on 20 November 2017

Proteome-level interplay between folding and aggregation propensities of proteins

scientific article

Proteome-wide observation of the phenomenon of life on the edge of solubility

scientific article published on 31 December 2019

Quantitative predictions of protein interactions with long noncoding RNAs

scientific article published in December 2016

RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43

RNA structure drives interaction with proteins

scientific article published on 19 July 2019

RNA-centric approaches to study RNA-protein interactions in vitro and in silico

scientific article published on 26 September 2019

RNA-protein interactions: Central players in coordination of regulatory networks

scientific article published on 07 December 2020

RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data

scientific article published on 01 January 2019

Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome/interstitial cystitis

scientific article published on 24 May 2018

SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation

scientific article published on 29 October 2018

SeAMotE: a method for high-throughput motif discovery in nucleic acid sequences

scientific article

Sequence-Based Prediction of Protein Behavior

Sequence-based prediction of protein solubility

scientific article

Short-Term Ultramicronized Palmitoylethanolamide Therapy in Patients with Myasthenia Gravis: a Pilot Study to Possible Future Implications of Treatment

scientific article published on 01 January 2019

Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides

scientific article published on June 2007

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

scientific article

Structural analysis of SARS-CoV-2 and predictions of the human interactome

scientific article published on 01 April 2020

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

scientific article

The Grand Challenge of Characterizing Ribonucleoprotein Networks

scientific article published on 9 June 2016

The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.

scientific article

The Zyggregator method for predicting protein aggregation propensities

scientific article published on 27 May 2008

The cleverSuite approach for protein characterization: predictions of structural properties, solubility, chaperone requirements and RNA-binding abilities.

scientific article

The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution.

scientific article

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism

scientific article published on 01 May 2019

The mutational landscape of a prion-like domain

scientific article published on 13 September 2019

The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates

scientific article published on 28 May 2004

Towards quantitative predictions in cell biology using chemical properties of proteins

scientific article published on 04 September 2008

Translationally optimal codons associate with aggregation-prone sites in proteins

scientific article

Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy.

scientific article published on 22 December 2017

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

scientific article published on 31 October 2013

X-inactivation: quantitative predictions of protein interactions in the Xist network.

scientific article published on 22 October 2012

catRAPID omics: a web server for large-scale prediction of protein-RNA interactions

scientific article

catRAPID signature: identification of ribonucleoproteins and RNA-binding regions

scientific article published on 31 October 2015

ccSOL omics: a webserver for solubility prediction of endogenous and heterologous expression in Escherichia coli

scientific article published on July 2014

omiXcore: a web server for prediction of protein interactions with large RNA.

scientific article

List of works by Gian Gaetano Tartaglia

A Computational Approach for the Discovery of Protein–RNA Networks

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

A Method for RNA Structure Prediction Shows Evidence for Structure in lncRNAs

A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

A high-throughput approach to profile RNA structure

A metastable subproteome underlies inclusion formation in muscle proteinopathies

A method for RNA structure prediction shows evidence for structure in lncRNAs

A relationship between mRNA expression levels and protein solubility in E. coli

ALMOST: an all atom molecular simulation toolkit for protein structure determination.

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

Advances in the characterization of RNA-binding proteins

Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

An Integrative Study of Protein-RNA Condensates Identifies Scaffolding RNAs and Reveals Players in Fragile X-Associated Tremor/Ataxia Syndrome

Assembly of Proteins by Free RNA during the Early Phase of Proteostasis Stress

BacFITBase: a database to assess the relevance of bacterial genes during host infection

By the company they keep: interaction networks define the binding ability of transcription factors

CROSSalive: a web server for predicting the in vivo structure of RNA molecules

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins

Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin

Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin

Competition between intramolecular and intermolecular interactions in an amyloid-forming protein

Computational analysis of the S. cerevisiae proteome reveals the function and cellular localization of the least and most amyloidogenic proteins

Constitutive patterns of gene expression regulated by RNA-binding proteins

Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisations

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing

Discovering the 3' UTR-mediated regulation of alpha-synuclein

Discovery of protein-RNA networks

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

DnaK functions as a central hub in the E. coli chaperone network

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells

Homage to Chris Dobson

Insights into the structure-driven protein interactivity of RNA molecules

Insights on protein thermal stability: a graph representation of molecular interactions

Insights on protein thermal stability: a graph representation of molecular interactions

Interactions in the native state of monellin, which play a protective role against aggregation

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

Modulation of human corticospinal excitability by paired associative stimulation in patients with amyotrophic lateral sclerosis and effects of Riluzole

Molecular Pathophysiology of Fragile X-Associated Tremor/Ataxia Syndrome and Perspectives for Drug Development.

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase

Neurodegeneration and Cancer: Where the Disorder Prevails

Neurodegeneration as an RNA disorder ⬇️

Neurodegenerative diseases: quantitative predictions of protein-RNA interactions

Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma

Nivolumab as a safe and effective treatment in an HIV patient with refractory Hodgkin lymphoma

Non-random distribution of homo-repeats: links with biological functions and human diseases

Organism complexity anti-correlates with proteomic beta-aggregation propensity

Phase Separations Driven by RNA Scaffolds and Protein Sequestration in FXTAS

Phase separation drives X-chromosome inactivation: a hypothesis

Physicochemical Principles of Protein Aggregation

Physicochemical determinants of chaperone requirements

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

Position-dependent electrostatic protection against protein aggregation

Post-transcriptional regulatory patterns revealed by protein-RNA interactions

Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1

Predicting protein associations with long noncoding RNAs

Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences

Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

Prediction of aggregation-prone regions in structured proteins

Prediction of protein-RNA interactions from single-cell transcriptomic data

Predictions of protein-RNA interactions

Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein

Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation

Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets

Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs

Proteome-level interplay between folding and aggregation propensities of proteins

Proteome-wide observation of the phenomenon of life on the edge of solubility

Quantitative predictions of protein interactions with long noncoding RNAs

RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43