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List of works by Bharath Wootla

A Comparison of Human Natural Monoclonal Antibodies and Aptamer Conjugates for Promotion of CNS Remyelination: Where Are We Now and What Comes Next?

scientific article published on 20 February 2018

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis.

scientific article published on 28 May 2015

A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes

scholarly article

A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.

scientific article published on 29 April 2015

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

scientific article published on 14 April 2020

Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice

scientific article published on 28 May 2015

Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease

scientific article

Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases

scientific article

Autoantibodies with enzymatic properties in human autoimmune diseases

scientific article

CD8(+) T cells in multiple sclerosis.

scientific article published on 06 July 2013

Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire.

scientific article published on September 2013

Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis

scientific article

Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis

scientific article

Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation.

scientific article published in January 2008

Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia

scientific article

Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients.

scientific article published on 11 April 2016

High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance.

scientific article

IVIg treatment reduces catalytic antibody titers of renal transplanted patients

scientific article

Immune response against therapeutic factor VIII in hemophilia A patients--a survey of probable risk factors.

scientific article published on 13 April 2007

Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: A mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies

article

Is Multiple Sclerosis an Autoimmune Disease?

scientific article (publication date: 2012)

NHE4 is critical for the renal handling of ammonia in rodents

scientific article

Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases.

scientific article published on 21 September 2015

Need for a paradigm shift in therapeutic approaches to CNS injury

scientific article

PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor

scientific article

Pathophysiology of catalytic antibodies

scientific article

Physiopathology of catalytic antibodies: the case for factor VIII-hydrolyzing immunoglobulin G.

scientific article

Polyclonal and monoclonal antibodies in clinic

scientific article published on January 2014

Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders.

scientific article

Proteolytic antibodies activate factor IX in patients with acquired hemophilia.

scientific article published on 3 December 2010

Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice.

scientific article

The road to remyelination in demyelinating diseases: current status and prospects for clinical treatment.

scientific article published on June 2013

Tissue kallikrein permits early renal adaptation to potassium load

scientific article

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors.

scientific article published on 19 September 2006

Varied immune response to FVIII: presence of proteolytic antibodies directed to factor VIII in different human pathologies

scientific article published on October 2009

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