List of works by Jesus M. Paramio

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer

scientific article published on 17 October 2015

A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer

scientific article

A humanized mouse model of HPV-associated pathology driven by E7 expression

scientific article

A novel tumor suppressor network in squamous malignancies

scientific article

A role for phosphorylation in the dynamics of keratin intermediate filaments.

scientific article published on January 1999

Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

scientific article published on 10 December 2016

Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.

scientific article published in June 2003

Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma.

scientific article published on 27 January 2009

Akt mediates an angiogenic switch in transformed keratinocytes

scientific article published on 4 March 2004

Akt pathway as a target for therapeutic intervention in HNSCC.

scientific article published on October 2008

Akt signaling leads to stem cell activation and promotes tumor development in epidermis.

scientific article published on July 2014

Altered T cell differentiation and Notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus.

scientific article published in June 2005

Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer.

scientific article

BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer.

scientific article

Beyond structure: do intermediate filaments modulate cell signalling?

scientific article

Bosutinib Inhibits EGFR Activation in Head and Neck Cancer

scientific article published on 21 June 2018

CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status

scientific article published on 21 September 2018

Clusterization in head and neck squamous carcinomas based on lncRNA expression: molecular and clinical correlates.

scientific article published on 08 April 2017

Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.

scientific article

Comparative study of the lethal effects of near-UV light (360 nm) and 8-methoxypsoralen plus near-UV on plasmid DNA

scientific article published on 01 January 1991

Competitive Repopulation Assay of Long-Term Epidermal Stem Cell Regeneration Potential

scientific article published on 01 January 2020

DNA Methylation as a Therapeutic Target for Bladder Cancer

scientific article published on 07 August 2020

Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer

scientific article

Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo.

scientific article published on 4 May 2010

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.

scientific article published on 30 September 2016

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis

scientific article published on 30 July 2018

Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes

scientific article published on 14 October 2019

Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation

scientific article

E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis

scientific article published on 13 August 2012

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours

scientific article

EZH2 in Bladder Cancer, a Promising Therapeutic Target

scientific article

Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia.

scientific article published on 3 March 2005

Epigenetics of Bladder Cancer: Where Biomarkers and Therapeutic Targets Meet

scientific article published on 18 November 2019

Establishment of a murine epidermal cell line suitable for in vitro and in vivo skin modelling ⬇️

scientific article

Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis.

scientific article published on December 2002

Ezh2-dependent therapies in bladder cancer: synthetic lethality

scientific article published in December 2017

Functional roles of Akt signaling in mouse skin tumorigenesis.

scientific article published on January 2002

Further studies on the lethal and mutagenic effects of 8-methoxypsoralen-induced lesions on plasmid DNA

scientific article published on 01 January 1991

G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas

scientific article published on 18 December 2019

Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status

scientific article published on 17 July 2019

Gene expression profiling as a tool for basic analysis and clinical application of human cancer.

scientific article published on August 2008

Gene expression profiling of mouse epidermal keratinocytes

scientific article published on January 2010

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy

scientific article

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis.

scientific article

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

scientific article published on 01 June 2020

Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway

scientific article published on 13 November 2003

IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization

scientific article published on 07 February 2019

IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development.

scientific article published on 8 October 2016

IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent

scientific article

Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis

scientific journal article

Impaired hair growth and wound healing in mice lacking thyroid hormone receptors

scientific article

In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.

scientific article published on 24 September 2014

In vivo transplantation of genetically modified mouse embryonic epidermis

scientific article published on 01 January 2010

Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells.

scientific article published on 29 June 2017

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

scientific article published on 03 July 2019

Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A

scientific article

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

scientific article

Integrative Metabolomic and Transcriptomic Analysis for the Study of Bladder Cancer.

scientific article published on 16 May 2019

Is the loss of pRb essential for the mouse skin carcinogenesis?

scientific article

Isolation of adult mouse stem keratinocytes using magnetic cell sorting (MACS)

scientific article published on 01 January 2010

Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins.

scientific article published on May 1997

Lethal and mutagenic effects of 8-methoxypsoralen-induced lesions on plasmid DNA.

scientific article

Liquid Biopsy Biomarkers in Bladder Cancer: A Current Need for Patient Diagnosis and Monitoring

scientific article published on 24 August 2018

Macrophage polarization as a novel weapon in conditioning tumor microenvironment for bladder cancer: can we turn demons into gods?

scientific article published on 05 October 2018

Molecular determinants of Akt-induced keratinocyte transformation

scientific article

NOTCH pathway inactivation promotes bladder cancer progression

scientific article

Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma.

scientific article published on 23 March 2017

On the origin of epidermal cancers

scientific article published on April 2009

Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer

scientific article published on 2 January 2017

Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation

scientific article published on 01 December 2000

Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway.

scientific article

PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors

scientific article published on 18 December 2013

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

scientific article

Premature aging and cancer development in transgenic mice lacking functional CYLD

article

Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.

scientific article published on 03 March 2016

RNA Detection in Urine: From RNA Extraction to Good Normalizer Molecules

scientific article published on 14 November 2015

Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis

scientific article published in October 2001

Role of protin kinases in the in vitro differentiation of human epidermal HaCaT cells ⬇️

scientific article published on July 1, 1997

Skin Tumors Rb(eing) Uncovered.

scientific article published on 17 December 2013

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

scientific article published on 01 February 2008

Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation

scientific article

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.

scientific article published in November 2008

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models

scientific article

The Ras-related gene ERAS is involved in human and murine breast cancer

scientific article published in Scientific Reports

The Rb family connects with the Tp53 family in skin carcinogenesis

scientific article published on August 2007

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior

scientific article

The ends of a conundrum?

scientific article published on 01 April 2007

The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis

scientific article

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis

scientific journal article

The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.

scientific article

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

scientific article published on 19 May 2015

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

scientific article

The thyroid hormone receptors as modulators of skin proliferation and inflammation

scientific article

The thyroid hormone receptors modulate the skin response to retinoids

scientific article

The transcriptional co-activator YAP: A new player in head and neck cancer

scientific article published on 11 September 2018

Thyroid Hormone Receptor β Inhibits Self-Renewal Capacity of Breast Cancer Stem Cells

scientific article published on 30 December 2019

Thyroid Hormone Receptors Regulate the Expression of microRNAs with Key Roles in Skin Homeostasis

scientific article published on 11 June 2018

Thyroid hormone signaling controls hair follicle stem cell function.

scientific article published on 5 February 2015

Transient transfections and heterokaryons as tools for the analysis of keratin IF dynamics.

scientific article

Unexpected roles for pRb in mouse skin carcinogenesis

scientific article published on 01 November 2005

Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis

scientific article published in June 2004

UroMark-a urinary biomarker assay for the detection of bladder cancer.

scientific article published on 31 January 2017

Urothelial cancer proteomics provides both prognostic and functional information.

scientific article published on 17 November 2017

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

scientific article published on 22 September 2020

Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms

scientific article published on 07 August 2018

p107 acts as a tumor suppressor in pRb-deficient epidermis.

scientific article

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

scientific article published on 14 October 2013

p53 is phosphorylated at the carboxyl terminus and promotes the differentiation of human HaCaT keratinocytes.

scientific article

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