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List of works by Vadivel Ganapathy

A high-affinity, tryptophan-selective amino acid transport system in human macrophages

scientific article published on 22 September 2006

A novel pineal-specific product of the oligopeptide transporter PepT1 gene: circadian expression mediated by cAMP activation of an intronic promoter

scientific journal article

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger

scientific article

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

scientific article

Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia

scientific article published on February 2013

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia

scientific article published on 10 July 2014

Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs

scientific article published on 08 April 2015

Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2) ⬇️

scientific article published on August 4, 2010

Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes

scientific article published on 18 October 2006

An anti-tumor role for cGMP-dependent protein kinase

scientific article published on 25 October 2005

Analysis of sigma receptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

scientific article

Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells

scientific article published on 17 April 2013

Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans

scientific article

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases

scientific article published on 2 July 2010

Carnitine Deficiency in OCTN2−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response ⬇️

scientific article published on October 24, 2012

Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice

scientific journal article

Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health

scientific article published on 10 August 2017

Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer

scientific article

Citrate transport and metabolism in mammalian cells: prostate epithelial cells and prostate cancer

scientific article published on January 2009

Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types

scientific article

Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)

scientific journal article

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.

scientific article published on January 2009

Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth

scientific article published on 05 April 2016

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

scientific article

Cystathionine beta synthase expression in mouse retina

scientific article published on 07 March 2013

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

scientific article published on 24 April 2015

Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis

scientific article

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer

scientific article published on 13 May 2015

Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1 ⬇️

scientific article published on November 30, 2012

Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon

scientific article

Differential modulation of sodium- and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids

scientific article published on 26 January 2007

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

scientific article

Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer.

scientific article published on September 2007

Drugs of abuse and human placenta ⬇️

scientific article published on October 16, 2010

Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells

scientific article published on 21 January 2009

Electrophysiological Characterization of the Polyspecific Organic Cation Transporter Plasma Membrane Monoamine Transporter ⬇️

scientific article published on March 6, 2012

Enzymes involved in L-carnitine biosynthesis are expressed by small intestinal enterocytes in mice: implications for gut health

scientific article

Evidence for two different broad-specificity oligopeptide transporters in intestinal cell line Caco-2 and colonic cell line CCD841 ⬇️

scientific article published on February 9, 2011

Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells

scientific article published on November 2005

Expression and function of iron-regulatory proteins in retina

scientific article published on May 2010

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

scientific article published on 08 August 2008

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines

scientific journal article

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

scientific article

Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.

scientific article published on 16 February 2009

Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis

scientific article

Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells

scientific article published on December 2006

Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development

scientific article

Functional and molecular identification of sodium-coupled dicarboxylate transporters in rat primary cultured cerebrocortical astrocytes and neurons

scientific journal article

Functional characterization, localization, and molecular identification of rabbit intestinal N-amino acid transporter

scientific article

Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for tricarboxylic acid cycle intermediates

scientific journal article

Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids

scientific article (publication date: 2 April 2004)

Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE.

scientific article published on 10 September 2008

Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates

scientific article

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy

scientific article

GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

scientific article published on 10 March 2009

Glutamine transporters in mammalian cells and their functions in physiology and cancer

scientific article published on 24 December 2015

H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.

scientific article published in November 2004

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe.

scientific article published on April 2008

Heterologous expression of Pharaonis halorhodopsin in Xenopus laevis oocytes and electrophysiological characterization of its light-driven Cl- pump activity

scientific article

Heterologous expression systems for studying placental transporters

scientific article published on January 2006

Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function

scientific journal article

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

scientific article

Human solute carrier SLC6A14 is the beta-alanine carrier

scientific article published on 03 July 2008

IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression

scientific article

IFN-γ Upregulates Survivin and Ifi202 Expression to Induce Survival and Proliferation of Tumor-Specific T Cells ⬇️

scientific article published on November 22, 2010

IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer

scientific article published on 3 March 2015

Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

scientific article published on October 2003

Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells

scientific article published on 30 July 2009

Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain

scientific article published on July 2006

Identity of the high-affinity sodium/carboxylate cotransporter NaC3 as the N-acetyl-L-aspartate transporter

scientific article published on January 2006

Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors

scientific article

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine

scientific article published on 09 May 2008

Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis

scientific article published on April 2016

Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium

scientific article

Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8).

scientific article published on June 2006

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

scientific article

Interferon-γ induces a tryptophan-selective amino acid transporter in human colonic epithelial cells and mouse dendritic cells

scientific article

Iron-mediated retinal degeneration in haemojuvelin-knockout mice ⬇️

scientific article published on January 15, 2012

Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles

scientific article

Kidney Proximal Tubular Epithelial-Specific Overexpression of Netrin-1 Suppresses Inflammation and Albuminuria through Suppression of COX-2-Mediated PGE2 Production in Streptozotocin-Induced Diabetic Mice ⬇️

scientific article published on October 2, 2012

L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium

scientific article published on 07 January 2014

Lactobacillus GG and tributyrin supplementation reduce antibiotic-induced intestinal injury

scientific article

Late-Onset Inner Retinal Dysfunction in Mice Lacking Sigma Receptor 1 (σR1) ⬇️

scientific article published on September 29, 2011

Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis

scientific article published on 14 April 2010

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells

scientific article published on 7 January 2013

Molecular and biochemical characterization of folate transport proteins in retinal Müller cells

scientific article

Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier

scientific journal article

Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells

scientific article

Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina

scientific article

NF-κB Directly Regulates Fas Transcription to Modulate Fas-mediated Apoptosis and Tumor Suppression ⬇️

scientific article published on June 5, 2012

National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development

scientific article

Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery

scientific article published on 29 October 2016

Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond

scientific article

Osmoregulation of taurine transporter function and expression in retinal pigment epithelial, ganglion, and müller cells

scientific article published on February 2004

Plasma Membrane Na⁺-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy

scientific article published on 28 February 2017

Polarized Distribution of Heme Transporters in Retinal Pigment Epithelium and Their Regulation in the Iron-Overload Disease Hemochromatosis ⬇️

scientific article published on November 29, 2011

Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand

scientific article

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

scientific article published on 07 December 2015

Protein Expressions and Genetic Variations of SLC5A8 in Prostate Cancer Risk and Aggressiveness ⬇️

scientific article published on July 29, 2011

Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis

scientific article

Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine

scientific article published on June 2016

Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart

scientific article

Regulation of proton‐coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate ⬇️

scientific article published on November 9, 2011

Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells ⬇️

scientific article published on December 1, 2003

Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate

scientific article published on January 2005

Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

scientific article

Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans

scientific article published on April 2004

Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells

scientific article

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia

scientific article published on April 2015

Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis

scientific article

Retinal transfer of nicotinate by H+-monocarboxylate transporter at the inner blood-retinal barrier ⬇️

scientific article published on June 29, 2011

Role of transporters in placental transfer of drugs

scientific article

SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer

scientific article published on 15 September 2011

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

scientific article

SLC19: the folate/thiamine transporter family

scientific article (publication date: February 2004)

SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter

scientific article

SLC5A8 Nuclear Translocation and Loss of Expression are Associated With Poor Outcome in Pancreatic Ductal Adenocarcinoma ⬇️

scientific article published on August 1, 2012

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases

scientific article

SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer ⬇️

scientific article published on July 19, 2011

Serine racemase and D-serine transport in human placenta and evidence for a transplacental gradient for D-serine in humans

scientific article

Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain

scientific article published on October 2015

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger

scientific article

Sigma Receptor 1 Modulates Endoplasmic Reticulum Stress in Retinal Neurons ⬇️

scientific article published on January 25, 2011

Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

scientific article published on December 2014

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

scientific article published on 28 January 2014

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

scientific article published on 18 May 2015

Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family

scientific article published on May 2005

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter

scientific article

Sodium-coupled monocarboxylate transporters in normal tissues and in cancer

scientific article published on 02 April 2008

Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer

scientific article

Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis

scientific article published on 23 August 2012

Species-specific influence of lithium on the activity of SLC13A5 (NaCT): lithium-induced activation is specific for the transporter in primates

scientific article

Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice

scientific article

Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2.

scientific article

Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2

scientific article

Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain

scientific journal article

Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2 ⬇️

scientific article published on May 16, 2003

Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2).

scientific article

The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function ⬇️

scientific article published on February 15, 2013

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

scientific article published on April 2004

Transcellular transfer of folate across the retinal pigment epithelium

scientific article published on February 2002

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

scientific article published on October 2009

Transport characteristics of N-acetyl-L-aspartate in rat astrocytes: involvement of sodium-coupled high-affinity carboxylate transporter NaC3/NaDC3-mediated transport system

scientific journal article

Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon

scientific article

Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+)

scientific article published on 13 September 2007

Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis ⬇️

scientific article published on January 8, 2011

Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract

scientific article

Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine

scientific article published on 29 September 2009

Transport of the synthetic opioid peptide DADLE ([D-Ala2,D-Leu5]-enkephalin) in neuronal cells

scientific article published on 08 September 2011

Transport systems for opioid peptides in mammalian tissues

scientific article

Transport via SLC5A8 (SMCT1) Is Obligatory for 2-Oxothiazolidine-4-Carboxylate to Enhance Glutathione Production in Retinal Pigment Epithelial Cells ⬇️

scientific article published on July 29, 2011

Transporter occluded-state conformation-induced endocytosis: Amino acid transporter ATB0,+-mediated tumor targeting of liposomes for docetaxel delivery for hepatocarcinoma therapy

scientific article published on 31 October 2016

Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

scientific article published on 23 August 2013

Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa

scientific article published on May 3, 2012

Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans

scientific article

c/ebpdelta Null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney

scientific article published on 26 July 2006

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