List of works by Ming Lei

18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.

scientific article

A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases.

scientific article published on July 2011

A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin

scientific article

Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A

scientific article published on 24 September 2011

Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification

scientific article published on 25 June 2013

Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.

scientific article

Altered expression of gap junction connexin proteins may partly underlie heart rhythm disturbances in the streptozotocin-induced diabetic rat heart

scientific article published on 14 July 2007

Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.

scientific article published on 27 January 2012

Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/- hearts.

scientific article

Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction.

scientific article published on 16 June 2010

Cardiac arrhythmogenesis: a tale of two clocks?

scientific article published on 04 December 2019

Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

scientific article published on 5 March 2009

Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.

scientific article published on 18 January 2010

Characterisation of the transient outward K+ current in rabbit sinoatrial node cells

scientific article published on 01 June 2000

Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression

scientific article

Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes

scientific article published on August 2007

Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving

scientific article published on 28 July 2006

Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts

scientific article published on 06 November 2012

Connexins in the sinoatrial and atrioventricular nodes.

scientific article

Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel

scientific article

Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex

scientific article

Differences in sino-atrial and atrio-ventricular function with age and sex attributable to the Scn5a+/- mutation in a murine cardiac model.

scientific article published on 19 March 2010

Distribution and functional role of inositol 1,4,5-trisphosphate receptors in mouse sinoatrial node.

scientific article

Editorial: Ca(2+) Signaling and Heart Rhythm.

scientific article published on January 2015

Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes.

scientific article

Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer.

scientific article published on May 2010

FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.

scientific article

Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/- hearts: the effects of ageing and sex

scientific article published on 8 August 2012

Glycyrretinic acid blocks cardiac sodium channels expressed in Xenopus oocytes.

scientific article published on 25 June 2009

Growth factors mediated differentiation of mesenchymal stem cells to cardiac polymicrotissue using hanging drop and bioreactor.

scientific article published on 7 January 2015

Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node

scientific article published in March 2002

Heterogeneous expression of the delayed-rectifier K+ currents i(K,r) and i(K,s) in rabbit sinoatrial node cells

scientific article

High resolution optical mapping of cardiac electrophysiology in pre-clinical models

scientific article published in 2022

Inhibition by Compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit isolated sino-atrial node cells

scientific article published on 01 March 1998

Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide

scientific article

Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.

scientific article published in July 2000

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.

scientific article

Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.

scientific article

Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells.

scientific article published in January 2000

Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome

scientific article

Nitric oxide can increase heart rate by stimulating the hyperpolarization-activated inward current, I(f).

scientific article published in July 1997

Non-muscarinic and non-nicotinic inhibition by the acetylcholine analogue carbachol of the delayed rectifier potassium current, iK, in rabbit isolated sino-atrial node cells

scientific article published on 01 July 1999

Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21-activated kinase.

scientific article

Novel insights into mechanisms for Pak1-mediated regulation of cardiac Ca(2+) homeostasis.

scientific article published on 17 March 2015

Optimal iodine staining of cardiac tissue for X-ray computed tomography

scientific article

Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart

scientific article

Organisation of the mouse sinoatrial node: structure and expression of HCN channels

scientific article published on 15 November 2006

PAK1 is a novel cardiac protective signaling molecule

scientific article

Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice.

scientific article published on December 2005

Pak1 is required to maintain ventricular Ca²⁺ homeostasis and electrophysiological stability through SERCA2a regulation in mice.

scientific article published on 12 September 2014

Pak1: steps towards understanding the regulatory mechanisms of pacemaker function of the heart

scientific article published on 01 September 2007

Pharmacological changes in cellular Ca2+ homeostasis parallel initiation of atrial arrhythmogenesis in murine Langendorff-perfused hearts.

scientific article

Plasma membrane Ca2+ -ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in the mouse

scientific article published on 10 October 2017

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain

scientific article published on 29 September 2011

Regulation of Ca(2+) transient by PP2A in normal and failing heart

scientific article

Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells

scientific article published on 5 April 2007

Regulation of cardiac excitation and contraction by p21 activated kinase-1

scientific article published on October 2008

Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer.

scientific article

Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking

scientific article published on 14 July 2004

Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node

scientific article published on 10 August 2007

Role of the 293b-sensitive, slowly activating delayed rectifier potassium current, i(Ks), in pacemaker activity of rabbit isolated sino-atrial node cells

scientific article published in January 2002

SCN5A and sinoatrial node pacemaker function.

scientific article published on 19 January 2007

Selected contribution: axial stretch increases spontaneous pacemaker activity in rabbit isolated sinoatrial node cells.

scientific article published in November 2000

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

scientific journal article

Sinus node dysfunction in ATX-II-induced in-vitro murine model of long QT3 syndrome and rescue effect of ranolazine

scientific article

Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32.

scientific article published on 19 October 2015

Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes

scientific article

Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions.

scientific article published on 7 June 2011

Sudden cardiac death by Commotio cordis: role of mechano-electric feedback

scientific article (publication date: May 2001)

Swelling-induced decrease in spontaneous pacemaker activity of rabbit isolated sino-atrial node cells

scientific article published on 01 September 1998

TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.

scientific article published on 14 April 2011

The SCN5A mutation A1180V is associated with electrocardiographic features of LQT3.

scientific article

The age-dependence of atrial arrhythmogenicity in Scn5a+/- murine hearts reflects alterations in action potential propagation and recovery

scientific article published on 01 June 2012

The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue.

scientific article published on 13 April 2015

The sinoatrial node: cell size does matter

scientific article published in September 2007

Three-dimensional image reconstruction of distribution of Pnmt+ cell-derived cells in murine heart.

scientific article

Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca2+ transients in murine heart

scientific article published on 26 July 2018

Two components of the delayed rectifier potassium current, IK, in rabbit sino-atrial node cells.

scientific article published in September 1996

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

scientific article published on 5 October 2015

Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling

scientific article published on 27 September 2013

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