List of works - Jeffrey Brender

A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage

A partially folded structure of amyloid-beta(1-40) in an aqueous environment

scientific article

A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity

scientific article

A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc

scientific article published on 17 May 2011

Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes

article published in 2011

Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption

scientific article published on October 2012

Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.

scientific article

An Evolution-Based Approach to De Novo Protein Design.

scientific article

An evolution-based approach to De Novo protein design and case study on Mycobacterium tuberculosis.

scientific article

Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy

scientific article published in May 2009

Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences

scientific article published on 12 February 2013

Binding Moiety Mapping by Saturation Transfer Difference NMR

scientific article published on 01 January 2018

Biphasic effects of insulin on islet amyloid polypeptide membrane disruption.

scientific article

Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.

scientific article published on 8 January 2013

Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies

scientific article published on December 2005

Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

scientific article published on April 2009

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

scientific article

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides?

scientific article published on 17 July 2012

Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

scientific article

Dynamic Imaging of Glucose and Lactate Metabolism by C-MRS without Hyperpolarization

scientific article published on 04 March 2019

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

scientific article published on 01 February 2020

Functional dynamics in the active site of the ribonuclease binase

scientific article published on July 2001

GLASS: a comprehensive database for experimentally validated GPCR-ligand associations

scientific article

Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion

scientific article

High Resolution Structure of A Partially Folded Insulin Aggregation Intermediate

scientific article published on 18 July 2020

High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification

scientific article published on 3 July 2015

Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

scientific article published on 13 August 2019

In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.

scientific article published on 15 May 2014

Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide

scientific article published on April 2009

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

scientific article

Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: MECHANISTIC DETAILS STUDIED BY SPECTROSCOPY IN COMBINATION WITH MICROSCOPY

scientific article published on 27 September 2016

Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins

scientific article

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

scientific article published on 20 February 2013

Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78)

scientific article published on 29 April 2013

Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments

scientific article published on 15 March 2013

Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective

scientific article published on 25 September 2011

Membrane fragmentation by an amyloidogenic fragment of human Islet Amyloid Polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes

scientific article

Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.

scientific article published on December 2016

Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo

scientific article

NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP 248−286

scientific article

NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG.

scientific article

Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.

scientific article published on February 2014

Nonproductive Binding Modes as a Prominent Feature of Aβ40 Fiber Elongation: Insights from Molecular Dynamics Simulation

scientific article published on 10 August 2018

Orientation of amide-nitrogen-15 chemical shift tensors in peptides: a quantum chemical study.

scientific article

Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation.

scientific article

Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles

scientific article published on 27 October 2015

Probing the Sources of the Apparent Irreproducibility of Amyloid Formation: Drastic Changes in Kinetics and a Switch in Mechanism Due to Micellelike Oligomer Formation at Critical Concentrations of IAPP

scientific article published on 03 February 2015

Probing transient non-native states in amyloid beta fiber elongation by NMR

scientific article published on 01 April 2019

Protein structure prediction provides comparable performance to crystallographic structures in docking-based virtual screening.

scientific article

Quality of Prostate MRI: Is the PI-RADS Standard Sufficient?

scientific article published on 03 March 2020

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease

scientific article

Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.

scientific article published on 8 March 2013

Role of zinc in human islet amyloid polypeptide aggregation.

scientific article published on July 2010

Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers.

scientific article published on 12 November 2012

Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286).

scientific article published on 7 March 2012

Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes

scientific article published on June 2010

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

scientific article

Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy

scientific article

Synthesis and evaluation of 13C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C-MRI

scientific article published on 22 November 2018

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species

scientific article

Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI

scientific article published on 05 June 2020

The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency.

scientific article

Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

scientific article

Towards reduction of SAR in scaling up in vivo pulsed EPR imaging to larger objects

scientific article published on 14 December 2018

Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI

scientific article published on 22 July 2020

Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation

scientific article

List of works by Jeffrey Brender

A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage

A partially folded structure of amyloid-beta(1-40) in an aqueous environment

A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity

A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc

Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes

Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption

Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.

An Evolution-Based Approach to De Novo Protein Design.

An evolution-based approach to De Novo protein design and case study on Mycobacterium tuberculosis.

Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy

Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences

Binding Moiety Mapping by Saturation Transfer Difference NMR

Biphasic effects of insulin on islet amyloid polypeptide membrane disruption.

Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.

Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies

Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides?

Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

Dynamic Imaging of Glucose and Lactate Metabolism by C-MRS without Hyperpolarization

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Functional dynamics in the active site of the ribonuclease binase

GLASS: a comprehensive database for experimentally validated GPCR-ligand associations

Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion

High Resolution Structure of A Partially Folded Insulin Aggregation Intermediate

High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification

Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.

Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: MECHANISTIC DETAILS STUDIED BY SPECTROSCOPY IN COMBINATION WITH MICROSCOPY

Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78)

Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments

Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective

Membrane fragmentation by an amyloidogenic fragment of human Islet Amyloid Polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes

Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.

Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo

NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP 248−286

NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG.

Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.

Nonproductive Binding Modes as a Prominent Feature of Aβ40 Fiber Elongation: Insights from Molecular Dynamics Simulation

Orientation of amide-nitrogen-15 chemical shift tensors in peptides: a quantum chemical study.

Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation.

Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles

Probing the Sources of the Apparent Irreproducibility of Amyloid Formation: Drastic Changes in Kinetics and a Switch in Mechanism Due to Micellelike Oligomer Formation at Critical Concentrations of IAPP

Probing transient non-native states in amyloid beta fiber elongation by NMR

Protein structure prediction provides comparable performance to crystallographic structures in docking-based virtual screening.

Quality of Prostate MRI: Is the PI-RADS Standard Sufficient?

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease

Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.

Role of zinc in human islet amyloid polypeptide aggregation.

Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers.

Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286).

Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy

Synthesis and evaluation of 13C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C-MRI

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species

Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI

The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency.

Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

Towards reduction of SAR in scaling up in vivo pulsed EPR imaging to larger objects

Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI

Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide