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List of works by Tobias Hartmann

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

scholarly article
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

scientific article published on 01 September 1997
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

scientific article published in September 1996
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

scientific article
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

scientific article
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

scientific article published in September 2002
TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

scientific article
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

scientific article published on 12 June 2006
A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

scientific article
Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms

scientific article published on 15 February 2011
Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

scientific article published on October 1999
Innate immune receptor expression in normal brain aging

scientific article published on 9 February 2007
Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression

scientific article published on 01 April 1999
Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

scientific article published in May 2002
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein

scientific article published in November 2005
Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.

scientific article published in June 2005
Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

scientific article published in April 2008
Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease

scientific article published on 23 December 2013
Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease

scientific article
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.

scientific article published on 30 December 2016
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.

scientific article published in May 1999
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.

scientific article published on 28 October 2013
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

scientific article published on 30 October 2017
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons

scientific article published in January 2004
Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells.

scientific article
Role of amyloid beta in lipid homeostasis.

scientific article published on 07 May 2010
Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology.

scientific article published on 28 November 2010
Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

scientific article published on 14 June 2006
Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).

scientific article
The role of APP proteolytic processing in lipid metabolism.

scientific article published on 17 December 2011
Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

scientific article published on 25 January 2012
From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

scientific article published on 30 July 2011
Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy.

scientific article
Plasmalogens inhibit APP processing by directly affecting γ-secretase activity in Alzheimer's disease

scientific article published in April 2012
Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study

scientific article published on October 2013
The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease

scientific article
Shedding of APP limits its synaptogenic activity and cell adhesion properties.

scientific article published on 3 December 2014
Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism

scientific article
Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging

scientific article published on October 1, 1997
Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

scientific article published on 6 November 2013
The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

scientific article published on 25 November 2002
Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.

scientific article
The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol

scientific article published in January 2012
Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model.

scientific article published on 25 May 2015
M1 muscarinic receptors block caspase activation by phosphoinositide 3-kinase- and MAPK/ERK-independent pathways

scientific article published on 01 September 2000
Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

scientific article
Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein

scientific article published on 7 May 2014
Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.

scientific article published on 20 May 2017
APP Function and Lipids: A Bidirectional Link

scientific article published on 10 March 2017
Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice

scientific article published on 11 May 2013

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