List of works - Tobias Hartmann

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

scientific article published on 30 October 2017

A convenient room temperature polycondensation toward hyperbranched AB2-type all-aromatic polyesters with phenol terminal groups

A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease

scientific article published in January 2014

A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

scientific article

APP Function and Lipids: A Bidirectional Link

scientific article published on 10 March 2017

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

scientific article published on 19 May 2015

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

scientific article

Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.

scientific article published in May 1999

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.

scientific article published on 30 December 2016

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons

scientific article published in January 2004

Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing.

scientific article published on May 1996

Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model.

scientific article published on 25 May 2015

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

scientific article published on July 1999

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism

scientific article

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

scientific article published in September 1996

Antipsychotic medication is associated with selective alterations in ventricular cerebrospinal fluid Aβ 40 and tau in patients with intractable unipolar depression

scientific article published on 9 February 2011

Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging ⬇️

scientific article published on October 1, 1997

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

scientific article published in May 2002

Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression

scientific article published on 01 April 1999

Cerebrospinal fluid protein tau levels in the differential diagnosis of Alzheimer's disease

scientific article published in October 2000

Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy.

scientific article

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

scientific article published on 14 June 2006

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

scientific article published on 04 June 2018

Clinical characterization of a presenilin 1 mutation (F177S) in a family with very early-onset Alzheimer's disease in the third decade of life

scientific article published on 11 July 2013

Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein

scientific article published on 7 May 2014

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

scientific article published on 25 January 2012

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

scientific article

Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms

scientific article published on 15 February 2011

Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.

scientific article published on 13 March 2013

Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme

scientific article published on 4 April 2016

From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

scientific article published on 30 July 2011

Frontotemporal dementia: clinical, neuroimaging, and molecular biological findings in 6 patients.

scientific article published in October 2001

GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons

scientific article published in September 2006

Going the wrong road: Fyn and targeting of amyloid precursor protein to lipid rafts ⬇️

scientific article published on September 1, 2011

Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells.

scientific article

Impact of Vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in Alzheimer's disease.

scientific article published on 30 October 2013

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

scientific article published on 12 June 2006

Increased expression of presenilin 2 inhibits protein synthesis

scientific article published on 01 January 2002

Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

scientific article published in April 2008

Innate immune receptor expression in normal brain aging

scientific article published on 9 February 2007

Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.

scientific article

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein

scientific article published in November 2005

M1 muscarinic receptors block caspase activation by phosphoinositide 3-kinase- and MAPK/ERK-independent pathways

scientific article published on 01 September 2000

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.

scientific article published in June 2005

Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology.

scientific article published on 28 November 2010

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease

scientific article published on 23 December 2013

New Alzheimer amyloid beta responsive genes identified in human neuroblastoma cells by hierarchical clustering

scientific article

Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

scientific article published on October 1999

Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.

scientific article published on 20 May 2017

Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines.

scientific article published on January 2003

Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing

scientific article published on 8 December 2015

PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease

scientific article

Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study

scientific article published on October 2013

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease

scientific article

Plasmalogens inhibit APP processing by directly affecting γ-secretase activity in Alzheimer's disease

scientific article published in April 2012

Potential external source of Aβ in biological samples

scientific article published on 01 July 2002

Reduced cerebrospinal fluid estradiol levels are associated with increased beta-amyloid levels in female patients with Alzheimer's disease

scientific article

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

scientific article

Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation

scientific article

Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.

scientific article published on 2 June 2016

Response of Toll-like receptors in experimental Guillain-Barré syndrome: a kinetic analysis

scientific article published on 8 May 2012

Role of amyloid beta in lipid homeostasis.

scientific article published on 07 May 2010

Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance

scientific article published on January 2006

Shedding of APP limits its synaptogenic activity and cell adhesion properties.

scientific article published on 3 December 2014

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

scholarly article

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

scientific article published on 6 November 2013

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

scientific article

Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system.

scientific article

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

scientific article

Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice

scientific article published on 11 May 2013

The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease

scientific article

The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease

scientific article

The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol

scientific article published in January 2012

The plant sterol brassicasterol as additional CSF biomarker in Alzheimer's disease.

scientific article published on 17 May 2011

The role of APP proteolytic processing in lipid metabolism.

scientific article published on 17 December 2011

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

scientific article published on 25 November 2002

Therapeutic perspectives in Alzheimer's disease.

scientific article published on January 2006

Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease

scientific article published on 29 October 2016

Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).

scientific article

Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice

scientific article

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

scientific article published in September 2002

Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.

scientific article published on 28 October 2013

Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Abeta42 reduces their differentiation potential

scientific article

Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

scientific article

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.

scientific article published on 19 December 2017

Vitamin E: Curse or Benefit in Alzheimer's Disease? A Systematic Investigation of the Impact of α-, γ- and δ-Tocopherol on Aß Generation and Degradation in Neuroblastoma Cells.

scientific article published on January 2015

World Wide Fingers will advance dementia prevention

scientific article published on 16 December 2017

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

scientific article published on 29 January 2003

List of works by Tobias Hartmann

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

A convenient room temperature polycondensation toward hyperbranched AB2-type all-aromatic polyesters with phenol terminal groups

A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease

A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

APP Function and Lipids: A Bidirectional Link

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons

Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing.

Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model.

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

Antipsychotic medication is associated with selective alterations in ventricular cerebrospinal fluid Aβ 40 and tau in patients with intractable unipolar depression

Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging ⬇️

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression

Cerebrospinal fluid protein tau levels in the differential diagnosis of Alzheimer's disease

Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy.

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

Clinical characterization of a presenilin 1 mutation (F177S) in a family with very early-onset Alzheimer's disease in the third decade of life

Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms

Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.

Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme

From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

Frontotemporal dementia: clinical, neuroimaging, and molecular biological findings in 6 patients.

GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons

Going the wrong road: Fyn and targeting of amyloid precursor protein to lipid rafts ⬇️

Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells.

Impact of Vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in Alzheimer's disease.

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

Increased expression of presenilin 2 inhibits protein synthesis

Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

Innate immune receptor expression in normal brain aging

Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein

M1 muscarinic receptors block caspase activation by phosphoinositide 3-kinase- and MAPK/ERK-independent pathways

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.

Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology.

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease

New Alzheimer amyloid beta responsive genes identified in human neuroblastoma cells by hierarchical clustering

Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.

Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines.

Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing

PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease

Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease

Plasmalogens inhibit APP processing by directly affecting γ-secretase activity in Alzheimer's disease

Potential external source of Aβ in biological samples

Reduced cerebrospinal fluid estradiol levels are associated with increased beta-amyloid levels in female patients with Alzheimer's disease

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation

Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.

Response of Toll-like receptors in experimental Guillain-Barré syndrome: a kinetic analysis

Role of amyloid beta in lipid homeostasis.

Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance

Shedding of APP limits its synaptogenic activity and cell adhesion properties.

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system.

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice

The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease

The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease

The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol

The plant sterol brassicasterol as additional CSF biomarker in Alzheimer's disease.

The role of APP proteolytic processing in lipid metabolism.

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

Therapeutic perspectives in Alzheimer's disease.

Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease

Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).