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List of works by Paul Johnston

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

scientific article

A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

scientific article

Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform

scientific article

Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor

scientific article published on 06 September 2019

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

scientific article

Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library

scientific article published in June 2009

Cellular platforms for HTS: three case studies

scientific article

Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport.

scientific article

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

scientific article published on 15 July 2008

Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy

scientific article published on 30 April 2019

Design and activity of AP endonuclease-1 inhibitors

scientific article published on 19 April 2015

Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells

scientific article

Development and Validation of a High-Content Screening Assay to Identify Inhibitors of Cytoplasmic Dynein-Mediated Transport of Glucocorticoid Receptor to the Nucleus ⬇️

scientific article published on July 25, 2012

Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors

scientific article

Development and optimization of high-throughput in vitro protein phosphatase screening assays

scientific article

Drug resistance in the fission yeast Schizosaccharomyces pombe: pleiotropic mutations affecting the oleic acid and sterol composition of cell membranes

article

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity

scientific article

Erratum to: High Content Screening

scientific article published on 01 January 2018

Fc-receptor mediated protein phosphorylation in murine peritoneal macrophages

scientific article published on 01 October 1984

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

scientific article

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines

scientific article

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

scientific article

High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions.

scientific article published in January 2018

High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug Leads

scientific article published on 28 December 2018

High content screening biosensor assay to identify disruptors of p53-hDM2 protein-protein interactions.

scientific article published on January 2015

High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer

scientific article published on 15 August 2018

High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer

scientific article published on 7 December 2017

High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.

scientific article

High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer

scientific article published in January 2009

Homologous and heterologous desensitization of proto-oncogene cfos expression in murine peritoneal macrophages

article

Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review

scientific article

Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits

scientific article

Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database

scientific article published on 30 November 2018

Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone.

scientific article published in October 2017

Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules

scientific article published on 27 June 2017

Introduction and Welcome to the Society of Biomolecular Imaging and Informatics (SBI2)

scientific article published on 01 September 2014

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines

scientific article

Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: Correlation between drug and amino acid uptake and membrane ATPase activities

scientific article published in July 1983

Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: Evidence for the existence of pleiotropic mutations affecting energy dependent transport systems

article

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors

scientific article

Potentiation of Antibiotic Therapy for Bovine Mastitis by Recombinant Bovine Interleukin-2

scientific article published on 01 December 1992

Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation

scientific article

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

scientific article

Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.

scientific article published on 8 September 2016

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?

scientific article

STAT3 signaling: anticancer strategies and challenges.

scientific article

Standardization of high content imaging and informatics

scientific article (publication date: September 2015)

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors

scientific article

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

scientific article

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype

scientific article published on 30 July 2012

The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates.

scientific article published in January 2018

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites

scientific article published in May 2005

The production of 3D tumor spheroids for cancer drug discovery

scientific article

Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation

scientific article published on 24 October 2016

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