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List of works by Massimiliano Gnecchi

Allogeneic lethally irradiated cord blood mononuclear cells in no-option critical limb ischemia: a "box of rain".

scientific article published on 13 July 2013

Bone marrow-derived mesenchymal stem cells: isolation, expansion, characterization, viral transduction, and production of conditioned medium

scientific article

Cell Therapy for Heart Regeneration: Learning from the Past to Build a Brighter Future

scientific article published on 08 September 2018

Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation.

scientific article published on April 2015

Comparison of Outcomes of Staged Complete Revascularization Versus Culprit Lesion-Only Revascularization for ST-Elevation Myocardial Infarction and Multivessel Coronary Artery Disease.

scientific article published on 9 December 2016

Conditioned medium from human amniotic mesenchymal stromal cells limits infarct size and enhances angiogenesis

scientific article published on 30 March 2015

Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries

scientific article published on 27 September 2004

Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions

scientific article published in Scientific Reports

Early Complete Revascularization in Hemodynamically Stable Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease

scientific article published on 19 March 2019

Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction

scientific article

Effectiveness of adjunctive stent implantation following directional coronary atherectomy for treatment of left anterior descending ostial stenosis

scientific article published on 01 November 2002

Endothelium-targeted gene and cell-based therapies for cardiovascular disease.

scientific article published on 12 August 2004

Enhancing stem cell therapy through genetic modification

scientific article published on 01 October 2005

Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement

scientific article published on 01 April 2006

Favorable effect of glycoprotein IIbIIIa inhibitors among STEMI patients treated with primary PCI and incomplete ST resolution

scientific article published on 20 January 2019

From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2

scientific article published on 01 June 2019

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene.

scientific article published on 7 April 2018

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi003-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1.

scientific article published on 6 April 2018

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

scientific article published on 27 March 2019

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

scientific article published on 13 April 2019

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi006-A from a patient affected by an autosomal recessive form of long QT syndrome type 1

scientific article published on 20 November 2019

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene

scientific article published on 06 March 2019

Generation of two human induced pluripotent stem cell (hiPSC) lines from a long QT syndrome South African founder population

scientific article published on 24 July 2019

Genetic therapies for cardiovascular diseases

scientific article

Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function

Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection

scientific article published on 14 November 2020

Identification of a targeted and testable antiarrhythmic therapy for long-QT syndrome type 2 using a patient-specific cellular model

scientific article published on 21 July 2017

Induced pluripotent stem cell technology: Toward the future of cardiac arrhythmias

scientific article published on 21 March 2017

Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells

scientific article published on 01 May 2019

Mesenchymal stem cell therapy for heart disease.

scientific article published on 12 April 2012

Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation

scientific article published on 11 September 2006

Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism.

scientific article published on May 2004

NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis

scientific article published on 15 February 2020

Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis.

scientific article published on 28 July 2015

Optimized lentiviral transduction of human amniotic mesenchymal stromal cells.

scientific article published on 14 November 2017

Paracrine Mechanisms of Mesenchymal Stem Cells in Tissue Repair

scientific article

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

scientific article published in April 2005

Paracrine factors of human fetal MSCs inhibit liver cancer growth through reduced activation of IGF-1R/PI3K/Akt signaling

scientific article

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart ⬇️

scientific article published on August 19, 2010

Prognostic Impact of in-Hospital-Bleeding in Patients With ST-Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention

scientific article published on 4 August 2017

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

scientific article

Protocols for in vitro Differentiation of Human Mesenchymal Stem Cells into Osteogenic, Chondrogenic and Adipogenic Lineages

scientific article published in January 2016

Rat experimental model of myocardial ischemia/reperfusion injury: an ethical approach to set up the analgesic management of acute post-surgical pain

scientific article

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

scientific journal article

Smoker's paradox in ST-elevation myocardial infarction: Role of inflammation and platelets

scientific article published on 02 April 2019

Strategies for reducing door to balloon time in patients with acute myocardial infarction undergoing primary angioplasty: the Pavia experience

scientific article

Synthetic extracellular matrix mimic hydrogel improves efficacy of mesenchymal stromal cell therapy for ischemic cardiomyopathy

scientific article published on 13 January 2018

Testing the Paracrine Properties of Human Mesenchymal Stem Cells Using Conditioned Medium.

scientific article published in January 2016

The KCNH2-IVS9-28A/G mutation causes aberrant isoform expression and hERG trafficking defect in cardiomyocytes derived from patients affected by Long QT Syndrome type 2.

scientific article published on 12 April 2017

The Unstoppable Attraction for Induced Pluripotent Stem Cells ⬇️

scientific article published in September 2012

Therapeutic potential of endothelial progenitor cells in cardiovascular diseases.

scientific article

Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion

scientific article published in November 2011

microRNA and Cardiac Regeneration.

scientific article published on January 2015

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