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List of works by Werner J. Pichler

A cell surface ELISA for the screening of monoclonal antibodies to antigens on viable cells in suspension

scientific article published on 01 May 1994

A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals.

scientific article published on April 2004

Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses

scientific article (publication date: 2014)

Activation of T cells by carbamazepine and carbamazepine metabolites

scientific article

Acute pancreatitis due to pyritinol: An immune-mediated phenomenon ⬇️

scientific article published on August 1, 1998

Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific alphabeta+ T cell clones ⬇️

scientific article published on April 1, 1998

Allergy to antibacterials: the problem with beta-lactams and sulfonamides

scientific article published on 01 August 1998

Allergy to sulfonamides

scientific article published on 01 January 2013

Allergy workup of severe cutaneous adverse drug reactions: a light at the end of the tunnel?

scientific article

Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response.

scientific article

Alteration of Fc-receptor phenotype and proliferative capacity of Fc-IgG-receptor positive lymphocytes through interaction with soluble immune complexes of patients with SLE or RA

scientific article published on 01 January 1985

Anaphylactic shock after intradermal testing with betalactam antibiotics

scientific article published on 01 June 2008

Anaphylactic shock after subcutaneous injection of mandragora D3, a homeopathic drug

scientific article published on 01 November 2000

Anaphylactoid Reactions to Radiopaque Contrast Dye–Reply–I.

scientific article published in July 2009

Anaphylaxis to celecoxib

scientific article published in March 2002

Anaphylaxis to drugs: overcoming mast cell unresponsiveness by fake antigens

scientific article published on 11 August 2020

Anergy induction in human CD4+ T-cell clones by stimulation with soluble peptides does not require cell proliferation and is accompanied by elevated IL4 production

scientific article published on 01 October 1996

Anisakiasis: immunity, allergy or both? Lessons on the natural role of immunoglobulin E from a nematode infestation

scientific article published on 01 September 1999

Anti-CD4 antibody treatment of patients with rheumatoid arthritis: II. Effect of in vivo treatment on in vitro proliferative response of CD4 cells

scientific article published on 01 October 1989

Anti-amiodarone antibodies: detection and relationship to the development of side effects

scientific article published on 01 August 1988

Antigen-presenting cells and keratinocytes express interleukin-12 in allergic contact dermatitis

scientific article published on 01 January 2000

Antigen-presenting human T cells and antigen-presenting B cells induce a similar cytokine profile in specific T cell clones.

scientific article published in December 1993

Association of class I, II, and III MHC gene products with systemic lupus erythematosus. Results of a Central European multicenter study

scientific article published on 01 January 1989

Avidity determines T-cell reactivity in abacavir hypersensitivity.

scientific article published on 14 June 2012

Bioresonanz – diagnostischer und therapeutischer Unsinn

Boletus edulis: a digestion-resistant allergen may be relevant for food allergy

scientific article published in May 2002

CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity

scientific article published on 13 November 2007

CD80 and CD86 costimulatory molecules on circulating T cells of HIV infected individuals

scientific article published on 01 February 1999

Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide.

scientific article published on December 1993

Ceftobiprole associated agranulocytosis after drug rash with eosinophilia and systemic symptoms induced by vancomycin and rifampicin

scientific article published on February 2011

Cellular mechanisms of T cell mediated drug hypersensitivity.

scientific article

Characterisation of blood and synovial fluid lymphocytes from patients with rheumatoid arthritis and other joint diseases by monoclonal antibodies (OKT series) and acid alpha-naphthyl esterase staining

scientific article published on 01 January 1982

Characterization of T8 epitopes by enzymatic digestion, crossblocking, and involvement in cell-mediated lympholysis

scientific article published on 01 December 1985

Characterization of drug-specific T cells in lamotrigine hypersensitivity

scientific article published on June 2003

Chronic idiopathic urticaria: natural course and association with Helicobacter pylori infection

scientific article

Comparison of the Inhibitory Activity of Seven Anti-T8 Antibodies on Specific Cellular Cytotoxicity ⬇️

scientific article published on 01 October 1984

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

scientific article published in September 2002

Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole

scientific article published on 22 April 2010

Cytotoxic HIV-1 p55ᵍᵃᵍ-Specific CD4+ T Cells Produce HIV-Inhibitory Cytokines and Chemokines

scholarly article

Cytotoxic T lymphocytes derived from patients with chronic hepatitis C virus infection kill bystander cells via Fas-FasL interaction

scientific article published on February 2004

Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies.

scientific article published on June 2004

Delayed allergy-like reactions to X-ray contrast media: mechanistic considerations.

scientific article

Detection of specific IgE to quinolones

scientific article published on 01 January 2004

Diagnosis of immediate allergic reactions to beta‐lactam antibiotics ⬇️

scientific article published on October 1, 2003

Dichotomous effect of monocyte Fc receptor interaction on anti-CD3-induced immunoglobulin synthesis

scientific article published on 01 March 1990

Differences of T-cell activation by the anti-CD3 antibodies Leu4 and BMA030.

scientific article published on August 1987

Different effects of IL-2 addition or antibody crosslinking on T-cell subset stimulation by CD3 antibodies

scientific article published on 01 August 1986

Direct T-cell stimulations by drugs--bypassing the innate immune system.

scientific article

Discrimination of human CD4 T cell clones based on their reactivity with antigen-presenting T cells

scientific article

Down-regulation of IL-12 by topical corticosteroids in chronic atopic dermatitis.

scientific article

Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors

scientific article

Drug hypersensitivity: flare-up reactions, cross-reactivity and multiple drug hypersensitivity

scientific article published in February 2011

Drug hypersensitivity: questionnaire. EAACI interest group on drug hypersensitivity

scientific article published on 01 September 1999

Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity

scientific article published in March 2004

Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations

scientific article published on 01 September 2003

Drug-induced linear IgA bullous dermatosis associated with ceftriaxone- and metronidazole-specific T cells

scientific article published in January 1999

Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity

scientific article published on 18 February 2009

Dual antibody stimulation: role of monocyte products and activation requirements of T cell subsets

scientific article published in January 1990

Educational case series: Mechanisms of drug allergy.

scientific article published on 06 June 2011

Effect of chemotherapy on T-lymphocyte subsets in B-cell proliferative disorders

scientific article published on 01 March 1985

Effect of natural seasonal pollen exposure and repeated nasal allergen provocations on elevation of exhaled nitric oxide

scientific article

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

scientific article published on 26 February 2011

Enhancement of drug-specific lymphocyte proliferation using CD25(hi)-depleted CD3(+) effector cells

scientific article published on 13 February 2014

Epidermal Langerhans cells bear Fc and C3 receptors

scientific article published in Nature

Etiology and pathogenesis of adverse drug reactions.

scientific article published on 3 May 2012

Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions

scientific article published on 01 December 2000

Fc IgM receptors on human lymphoblastoid B cell lines ⬇️

scientific article published on April 1, 1978

Fever, pneumonia and eosinophilia

scientific article

Fulminant liver failure after vancomycin in a sulfasalazine-induced DRESS syndrome: fatal recurrence after liver transplantation

scientific article published in September 2009

General considerations for skin test procedures in the diagnosis of drug hypersensitivity

scientific article published on 01 January 2002

General considerations on rapid desensitization for drug hypersensitivity - a consensus statement.

scientific article published on 17 August 2010

HAART in HIV-infected patients: restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia

scientific article published on 01 October 1999

HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin

scientific article published on 17 April 2013

HLA-B*57:01(+) abacavir-naive individuals have specific T cells but no patch test reactivity

scientific article published on 23 May 2013

Highlights of the 4th Drug Hypersensitivity Meeting--Rome, April 22-25, 2010. Preface

scientific article published on 01 March 2011

Human afferent lymph from normal skin contains an increased number of mainly memory / effector CD4(+) T cells expressing activation, adhesion and co-stimulatory molecules

scientific article published on 01 February 2000

Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA.

scientific article published on 03 September 2012

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones

scientific article published in March 2003

Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy.

scientific article published on 31 October 2013

IgE mediated chlorhexidine allergy - cross-reactivity with other biguanide disinfectants

scientific article published on 17 July 2020

IgE-mediated anaphylaxis to intraarticular glucocorticoid preparations.

scientific article published in August 2009

Immune mechanism of drug hypersensitivity.

scientific article published in August 2004

Immune pathomechanism and classification of drug hypersensitivity

scientific article published on 29 April 2019

Immune pathomechanism of drug hypersensitivity reactions

scientific article published on 01 March 2011

Important questions in Allergy: 1--drug allergy/hypersensitivity

scientific article published on May 2008

In vitro detection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases.

scientific article

In vitro diagnosis of T cell-mediated drug allergy.

scientific article published on 22 February 2011

In vitro drug causality assessment in Stevens-Johnson syndrome - alternatives for lymphocyte transformation test

scientific article

In vitro tests in drug hypersensitivity diagnosis

scientific article

In vitro tests of T cell-mediated drug hypersensitivity.

scientific article

Incidence of anaphylaxis with circulatory symptoms: a study over a 3-year period comprising 940,000 inhabitants of the Swiss Canton Bern

scientific article published in February 2004

Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus Clearance

scientific article

Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria ⬇️

scientific article published on September 8, 2011

Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions

scientific article published on 01 June 2000

Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils

scientific article published on 01 October 1996

Inhibition of syncytia-inducing (SI) virus by autologous serum from HIV-1-infected individuals

scientific article published in August 1996

Interleukin-2 in the ontogeny of human lymphoid tissues

scientific article published on 01 January 1982

International Consensus on drug allergy.

scientific article published on April 2014

Involvement of CD80 in the generation of CD4+ cytotoxic T cells.

scientific article published on January 1996

Involvement of T cells in drug-induced allergies

scientific article published on 01 August 1998

Involvement of drug-specific T cells in acute drug-induced interstitial nephritis

scientific article published on 30 August 2006

Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study

scientific article published on 01 April 2006

Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions

scientific article published in February 2006

Macular exanthema appearing 5 days after X-ray contrast medium administration.

scientific article

Mechanisms of drug-induced allergy.

scientific article published on March 2009

Molecular basis of drug recognition by specific T-cell receptors.

scientific article

Monoclonal anti-CD4 in arthritis

scientific article published on 01 December 1987

Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells

scientific article published on 21 September 2011

NKp46+ cells express granulysin in multiple cutaneous adverse drug reactions

scientific article published on 05 August 2011

Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides

scientific article

Noncytotoxic human CD4+ T-cell clones presenting and simultaneously responding to an antigen die of apoptosis

scientific article

Nonimmediate drug allergy: diagnostic benefit of skin testing and practical approach.

scientific article published in April 2012

Only weak association between disease severity and HLA-DRB 1 genes in a Swiss population of rheumatoid arthritis patients

scientific article published in January 1996

Oral prednisolone induced acute generalized exanthematous pustulosis due to corticosteroids of group A confirmed by epicutaneous testing and lymphocyte transformation tests.

scientific article

Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01.

scientific article published on 3 March 2014

Pathogenesis of drug-induced exanthema

scientific article published in January 2001

Peptide vaccines against hepatitis B virus: from animal model to human studies.

scientific article

Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis

scientific article published in June 2001

Perspectives: towards a peptide-based vaccine against hepatitis C virus.

scientific article published in December 2001

Pharmacological interaction of drugs with immune receptors: the p-i concept.

scientific article published on March 2006

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project.

scientific article published in February 2009

Preface. Drug hypersensitivity

scientific article published on 01 August 2009

Processing-dependent and -independent pathways for recognition of iodinated contrast media by specific human T cells

scientific article published on 16 December 2009

Receptors for IgM on Human B Lymphocytes ⬇️

scientific article published on January 1, 1978

Recognition of local anesthetics by alphabeta+ T cells.

scientific article published on February 1999

Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy

scientific article

Robust expression of CCR3 as a single basophil selection marker in flow cytometry

scientific article published on 01 January 2011

Selective expression of T-cell receptor-V beta in acute infectious mononucleosis

scientific article published on 01 July 1995

Selective restimulation of antigen or allergen preactivated T cells using OKT3 F(ab)2 results in the secretion of TH-1 or TH-2-like cytokine patterns

scientific article published on 01 November 1995

Skin and laboratory tests in amoxicillin- and penicillin-induced morbilliform skin eruption

scientific article published on 01 April 2000

Skin testing in patients with hypersensitivity reactions to iodinated contrast media - a European multicenter study.

scientific article published in February 2009

Stimulation of human T cells with sulfonamides and sulfonamide metabolites.

scientific article published in February 2010

Strong alpha beta and gamma delta TCR response in a patient with disseminated Mycobacterium avium infection and lack of NK cells and monocytopenia

scientific article published on 01 May 2000

Studies on rosette formation of human lymphocytes with pig red blood cells

scientific article published on 01 January 1978

Sulfamethoxazole induces a switch mechanism in T cell receptors containing TCRVβ20-1, altering pHLA recognition

scientific article

Sézary syndrome with hyposplenism

scientific article published on 01 August 1984

T cell activation by cross-linking anti-CD3 antibodies with second anti-T cell antibodies: dual antibody cross-linking mimics physical monocyte interaction.

scientific article published on November 1987

T cell involvement in cutaneous drug eruptions

scientific article published on 01 September 2001

T cell reactivity to penicillin: phenotypic analysis of in vitro activated cell subsets

scientific article

T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity

scientific article published in January 2006

T cell-mediated reactions to iodinated contrast media: evaluation by skin and lymphocyte activation tests.

scientific article published on January 2005

T cells as antigen-presenting cells ⬇️

scientific article published on July 1, 1994

T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury

scientific article published on 13 April 2014

T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic

scientific article published on 01 October 2000

T-cell reaction to local anaesthetics: relationship to angioedema and urticaria after subcutaneous application--patch testing and LTT in patients with adverse reaction to local anaesthetics

scientific article published in November 1999

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays.

scientific article published on 18 August 2010

The area of drug hypersensitivity has been widely neglected not least because it is a complex area. Preface

scientific article published on 01 July 2010

The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity

scientific article published on 01 February 1997

The role of drug, dose, and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndrome

scientific article published on 09 December 2019

Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds.

scientific article published on 14 April 2006

Ultra rush bee venom immunotherapy does not reduce cutaneous weal responses to bee venom and codeine phosphate

scientific article published on 01 December 1995

Use of antibody/peptide constructs to direct antigenic peptides to T cells: Evidence for T cell processing and presentation ⬇️

scientific article published on January 1, 1992

Virological and immunological characteristics of HIV treatment failure

scientific article published in August 2000

[The significance of Fc-IgG and Fc-IgM receptors on human T-lymphocytes (author's transl)].

scientific article

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