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List of works by Rui E. Castro

A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

scientific article published on 31 May 2020

A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.

scientific article published on 7 April 2005

Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation

scientific article

Activation of necroptosis in human and experimental cholestasis.

scientific article published on 29 September 2016

Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.

scientific article

Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis

scientific article published on 01 January 2006

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.

scientific article

Apoptosis in transgenic mice expressing the P301L mutated form of human tau.

scientific article published in May 2008

Corrigendum: Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis

scientific article published on 24 June 2016

Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations.

scientific article published on 5 June 2013

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties

scientific article

Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation

scientific article published on 06 October 2020

Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes

scientific article published on 12 April 2007

Evaluation of Tissue and Circulating miR-21 as Potential Biomarker of Response to Chemoradiotherapy in Rectal Cancer

scientific article published on 14 September 2020

Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis.

scientific article published on 25 May 2006

Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients

scientific article published on 01 September 2004

Host miRNA-21 promotes liver dysfunction by targeting small intestinal <i>Lactobacillus</i> in mice

scientific article published on 01 November 2020

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid

scientific article

Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis.

scientific article

Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells

scientific article published in August 2004

Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning?

scientific article published on 20 May 2020

Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.

scientific article

MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

scientific article published on 29 April 2016

MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.

scientific article

Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes.

scientific article

Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells

scientific article published on 7 July 2016

Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents.

scientific article published on 24 March 2009

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.

scientific article

Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes

scientific journal article

Progesterone and Caspase-3 Activation in Equine Cyclic Corpora Lutea

scientific article published on 01 August 2007

Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease.

scientific article published on 28 April 2014

Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis

scientific article published on 28 May 2019

Synthesis and evaluation of water-soluble prodrugs of ursodeoxycholic acid (UDCA), an anti-apoptotic bile acid.

scientific article

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

scientific article published on 19 August 2013

Targeting miR-506 in primary biliary cirrhosis to support the HCO3− umbrella

scientific article published on 04 July 2012

Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.

scientific article published on September 2006

Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.

scientific article published on March 2009

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

scientific article

The Emerging Role of microRNAs in Aquaporin Regulation.

scientific article

The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.

scientific article

Towards a definite mouse model of NAFLD

scientific article published on 29 May 2018

Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53.

scientific article published on 31 August 2010

Ursodeoxycholic acid: effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.

scientific article published on 29 August 2017

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

scientific article

c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.

scientific article published on 13 January 2014

miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells.

scientific article published on 25 January 2016

miR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cells

scientific article

miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation

scientific article

miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice

scientific article

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

scientific article published on 15 August 2012

miRNA-21 ablation protects against liver injury and necroptosis in cholestasis.

scientific article published on 11 December 2017

p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.

scientific article published on 12 October 2009

p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis

scientific journal article

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