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List of works by Christopher J Lingle

A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells.

scientific article published on May 1997

A glutamate-activated chloride conductance on a crustacean muscle ⬇️

scientific article published on May 18, 1981

A human calcium-activated potassium channel gene expressed in vascular smooth muscle

scientific article

A limited access compartment between the pore domain and cytosolic domain of the BK channel.

scientific article published in November 2006

Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC.

scientific article published on 21 August 2005

Activation of skeletal muscle nicotinic acetylcholine receptors ⬇️

scientific article published on March 1, 1992

Activation of the primary kinetic modes of large- and small-conductance cholinergic ion channels in Xenopus myocytes.

scientific article

Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site

scientific article

Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors ⬇️

scientific article published on December 1, 1997

Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants.

scientific article published in July 2000

BK channel activation by brief depolarizations requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cells

scientific article published on 01 May 1999

BK channel inhibition by strong extracellular acidification

scientific article published on 02 July 2018

BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism.

scientific article

Block of glutamatergic excitatory synaptic channels by chlorisondamine

scientific article published on 01 March 1981

Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.

scientific article published on 02 January 2010

Blockade of cholinergic channels by chlorisondamine on a crustacean muscle

scientific article published on 01 June 1983

Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications

scientific article published on 6 April 2015

Calcium sensitivity of BK-type KCa channels determined by a separable domain.

scientific article published on September 1994

Calcium-activated potassium channels in adrenal chromaffin cells.

scientific article

Closed-channel block of BK potassium channels by bbTBA requires partial activation.

scientific article

Comparison of excitatory currents activated by different transmitters on crustacean muscle. II. Glutamate-activated currents and comparison with acetylcholine currents present on the same muscle.

scientific article

Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels

scientific article (publication date: March 2002)

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.

scientific article

Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa ⬇️

scientific article

Different types of blockade of crustacean acetylcholine-induced currents.

scientific article published in June 1983

Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells.

scientific article published on October 2009

Direct observation of a preinactivated, open state in BK channels with beta2 subunits

scientific article

Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.

scientific article

Empirical considerations regarding the use of ensemble-variance analysis of macroscopic currents

scientific article published on 30 June 2006

Enantioselective Blockade of T-type Ca2+ Current in Adult Rat Sensory Neurons by a Steroid That Lacks γ-Aminobutyric Acid-Modulatory Activity ⬇️

scientific article published on November 1, 1998

Engineering differential charge selectivity from a single structural template.

scientific article published on 28 October 2016

Functional regulation of BK potassium channels by γ1 auxiliary subunits.

scientific article published on 17 March 2014

Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini

scientific article published in June 2001

Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.

scientific article

Halothane Reduces Calcium Currents in Clonal (GH3) Pituitary Cells ⬇️

scientific article published on January 1, 1991

Halothane inhibits two components of calcium current in clonal (GH3) pituitary cells

scientific article published on July 1991

Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes

scientific article published on 01 September 1986

Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and noninactivating subunits.

scientific article

Inactivating and noninactivating Ca(2+)- and voltage-dependent K+ current in rat adrenal chromaffin cells

scientific article published in September 1995

Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues

scientific article

Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+.

scientific article

Kinetic and pharmacological properties of low voltage-activated Ca2+ current in rat clonal (GH3) pituitary cells.

scientific article

Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons

scientific article

Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.

scientific article

Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells

scientific article published on 17 April 2017

LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells

scientific article published on 26 August 2019

Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains.

scientific article published in June 2004

Membrane currents in identified lactotrophs of rat anterior pituitary.

scientific article

Mg2+-dependent regulation of BK channels: importance of electrostatics.

scientific article published on January 2008

Multiple components of voltage-dependent potassium current in normal rat anterior pituitary cells.

scientific article

Multiple regulatory sites in large-conductance calcium-activated potassium channels.

scientific article published in August 2002

N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels.

scientific article published on March 2009

NAVigating a transition from single action potential firing to bursting in chromaffin cells

scientific article published on 01 February 2015

Neuromuscular blocking agents

scientific article published on 01 January 1988

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.

scientific article

Pharmacological Properties of T-Type Ca2+ Current in Adult Rat Sensory Neurons: Effects of Anticonvulsant and Anesthetic Agents ⬇️

scientific article published on January 1, 1998

RINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels.

scientific article published in February 1999

Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.

scientific article

Redox-sensitive extracellular gates formed by auxiliary β subunits of calcium-activated potassium channels ⬇️

scientific article published on June 1, 2003

Regulation of BK Channels by Beta and Gamma Subunits

scientific article published on 01 February 2019

Regulatory γ1 subunits defy symmetry in functional modulation of BK channels

article published in the Proceedings of the National Academy of Sciences of the United States of America

Roles of Na+, Ca2+, and K+ channels in the generation of repetitive firing and rhythmic bursting in adrenal chromaffin cells.

scientific article

SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility

scientific journal article

Setting the stage for molecular dissection of the regulatory components of BK channels.

scientific article

Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa

scientific article published on September 2013

Slo3 K+ channels: voltage and pH dependence of macroscopic currents

scientific article

Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits

scientific article published in July 2008

Stereospecific binding of a disordered peptide segment mediates BK channel inactivation.

scientific article

The Anesthetic Steroid (+)-3α-Hydroxy-5α-androstane-17β-carbonitrile Blocks N-, Q-, and R-Type, but Not L- and P-Type, High Voltage-Activated Ca2+ Current in Hippocampal and Dorsal Root Ganglion Neurons of the Rat ⬇️

scientific article published on September 1, 1998

The Ca2+-activated K+ current of human sperm is mediated by Slo3.

scientific article published on 26 March 2014

The action of halothane on stimulus-secretion coupling in clonal (GH3) pituitary cells

scientific article published on July 1991

The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockers

scientific article

The functionally relevant site for paxilline inhibition of BK channels

scientific article published on 26 December 2019

The suppression of Ca(2+)- and voltage-dependent outward K+ current during mAChR activation in rat adrenal chromaffin cells

scientific article published on 01 June 1995

Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.

scientific article published on 12 October 2017

Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channel

scientific article published on September 18, 1992

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating

scientific article published on 21 September 2015

Two components of calcium-activated potassium current in rat adrenal chromaffin cells

scientific article published on 01 January 1992

[Ca2+]i elevations detected by BK channels during Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular stores in rat chromaffin cells

scientific article published on 01 July 1996

pH-regulated Slo3 K+ channels: properties of unitary currents

scientific article

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