List of works - Philippe Gual

A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies ⬇️

scientific article published on December 1, 1995

A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients.

scientific article published on 7 October 2010

Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling

scientific article published on February 2004

Autophagy and non-alcoholic fatty liver disease.

scientific article

Autophagy in chronic liver diseases: a friend rather than a foe?

scientific article published in March 2017

Autophagy in chronic liver diseases: the two faces of Janus

scientific article published on 30 November 2016

Autophagy, signaling and obesity

scientific article published on 13 September 2012

Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation

scientific article published on 11 March 2008

Baseline Anthropometric and Metabolic Parameters Correlate with Weight Loss in Women 1-Year After Laparoscopic Roux-En-Y Gastric Bypass.

scientific article published on 26 May 2017

Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling

scientific article published on 19 February 2018

Body composition, anthropometrics, energy expenditure, systemic inflammation, in premenopausal women 1 year after laparoscopic Roux-en-Y gastric bypass

scientific article published on 07 September 2013

C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

article

CD44 is a key player in non-alcoholic steatohepatitis

scientific article

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis

scientific article

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

scientific journal article

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

scientific article

Cross-talk between the proto-oncogenes Met and Ron

scientific article

Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1

scientific article published on 30 March 2015

Determinants associated with the correction of glomerular hyper-filtration one year after bariatric surgery.

scientific article published on 19 July 2017

Different point mutations in the met oncogene elicit distinct biological properties

scientific article published in February 2000

Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.

scientific article published on 3 August 2006

Differential requirement of the last C-terminal tail of Met receptor for cell transformation and invasiveness.

scientific article published on September 2001

ER stress induces NLRP3 inflammasome activation and hepatocyte death.

scientific article

Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia

scientific article published on 13 April 2018

Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots

scientific article published on 3 October 2013

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity

scientific article published on 24 October 2008

Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation

scientific article

Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling

scientific article (publication date: 11 January 2001)

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon

scientific article published in May 2008

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

scientific article

Hemojuvelin: A New Link Between Obesity and Iron Homeostasis

article by Nathalie Luciani et al published 10 February 2011 in Obesity

Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients

scientific article (publication date: 22 October 2010)

Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway

scientific article published on 6 February 2007

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

scientific article (publication date: 18 July 2003)

Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.

scientific article published on 18 December 2014

Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients

scientific article

Immunoglobulin G4-associated autoimmune hepatitis may be found in Western countries.

scientific article published on 22 October 2015

Impact of laparoscopic Roux-en-Y gastric bypass on metabolic syndrome, inflammation, and insulin resistance in super versus morbidly obese women

scientific article published on 19 November 2008

Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes

Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH

scientific article

Insulin receptor-induced phosphorylation of cellular and synthetic substrates is regulated by the receptor beta-subunit C-terminus

scientific article published on 01 August 1996

Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor

scientific article

Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

scientific article

Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease

scientific article

Low Levels of 25-Hydroxy Vitamin D are Independently Associated with the Risk of Bacterial Infection in Cirrhotic Patients

scientific article

M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease

scientific article published on 20 November 2013

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

scientific journal article

Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients

scientific article

Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease.

scientific article published on 28 May 2019

Non-alcoholic steatohepatitis in morbidly obese patients

scientific article published on 21 January 2013

Non-invasive Evaluation of NAFLD with Indocyanine Green Clearance Test: a Preliminary Study in Morbidly Obese Patients Undergoing Bariatric Surgery.

scientific article published on 5 September 2017

Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression

scientific article published on 15 March 2012

Osteopontin deficiency aggravates hepatic injury induced by ischemia-reperfusion in mice

scientific article

Pharmacological treatments of the "Fibrotic-NASH": Towards a delivery on time?

scientific article published on 09 July 2019

Positive and negative regulation of glucose uptake by hyperosmotic stress

scientific article published on December 2003

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

scientific article (publication date: 2005)

Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.

scientific article

Prophylaxis of bacterial infections in cirrhosis: is an optimal 25-OH vitamin D level required?

scientific article published on 11 July 2014

Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte

scientific article

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

scientific article published on June 2003

Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery

scientific article published on 20 July 2012

Role of the insulin receptor C-terminal acidic domain in the modulation of the receptor kinase by polybasic effectors

scientific article published on 01 October 1996

Roux-En Y Gastric Bypass Results in Long-Term Remission of Hepatocyte Apoptosis and Hepatic Histological Features of Non-alcoholic Steatohepatitis.

scientific article published on 19 August 2016

Screening for therapeutic trials and treatment indication in clinical practice: MACK-3, a new blood test for the diagnosis of fibrotic NASH.

scientific article published on 25 March 2018

Severe Vitamin D Deficiency Is Not Associated with Liver Damage in Morbidly Obese Patients.

scientific article published on 19 January 2016

Severe Vitamin D Deficiency May be an Additional Cofactor for the Occurrence of Alcoholic Steatohepatitis

scientific article published on 02 May 2015

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease

scientific article

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

scientific article (publication date: 16 March 2000)

The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis

scientific article published on 16 May 2019

The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH

scientific article published on 22 June 2006

The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease

scientific article (publication date: 2012)

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis

scientific article published on 11 April 2015

Therapeutic potential of nicotinamide adenine dinucleotide for nonalcoholic fatty liver disease

scientific article published on 16 February 2016

Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis

scientific article

Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production

scientific article published on 2 March 2018

[Metabolic fatty liver diseases: hepatic consequences of the metabolic syndrome]

scientific article published on 01 December 2007

[Obesity, diabetes and insulin resistance. Alterations of insulin signalling]

scientific article published on 01 January 2006

[Pathogenesis of non-alcoholic fatty liver disease]

scientific article published on 22 November 2019

List of works by Philippe Gual

A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies ⬇️

A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients.

Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling

Autophagy and non-alcoholic fatty liver disease.

Autophagy in chronic liver diseases: a friend rather than a foe?

Autophagy in chronic liver diseases: the two faces of Janus

Autophagy, signaling and obesity

Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation

Baseline Anthropometric and Metabolic Parameters Correlate with Weight Loss in Women 1-Year After Laparoscopic Roux-En-Y Gastric Bypass.

Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling

Body composition, anthropometrics, energy expenditure, systemic inflammation, in premenopausal women 1 year after laparoscopic Roux-en-Y gastric bypass

C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

CD44 is a key player in non-alcoholic steatohepatitis

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

Cross-talk between the proto-oncogenes Met and Ron

Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1

Determinants associated with the correction of glomerular hyper-filtration one year after bariatric surgery.

Different point mutations in the met oncogene elicit distinct biological properties

Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.

Differential requirement of the last C-terminal tail of Met receptor for cell transformation and invasiveness.

ER stress induces NLRP3 inflammasome activation and hepatocyte death.

Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia

Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity

Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation

Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling

Guidelines for the use and interpretation of assays for monitoring autophagy

HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

Hemojuvelin: A New Link Between Obesity and Iron Homeostasis

Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients

Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.

Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients

Immunoglobulin G4-associated autoimmune hepatitis may be found in Western countries.

Impact of laparoscopic Roux-en-Y gastric bypass on metabolic syndrome, inflammation, and insulin resistance in super versus morbidly obese women

Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes

Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH

Insulin receptor-induced phosphorylation of cellular and synthetic substrates is regulated by the receptor beta-subunit C-terminus

Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor

Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease

Low Levels of 25-Hydroxy Vitamin D are Independently Associated with the Risk of Bacterial Infection in Cirrhotic Patients

M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients

Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease.

Non-alcoholic steatohepatitis in morbidly obese patients

Non-invasive Evaluation of NAFLD with Indocyanine Green Clearance Test: a Preliminary Study in Morbidly Obese Patients Undergoing Bariatric Surgery.

Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression

Osteopontin deficiency aggravates hepatic injury induced by ischemia-reperfusion in mice

Pharmacological treatments of the "Fibrotic-NASH": Towards a delivery on time?

Positive and negative regulation of glucose uptake by hyperosmotic stress

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.

Prophylaxis of bacterial infections in cirrhosis: is an optimal 25-OH vitamin D level required?

Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery

Role of the insulin receptor C-terminal acidic domain in the modulation of the receptor kinase by polybasic effectors

Roux-En Y Gastric Bypass Results in Long-Term Remission of Hepatocyte Apoptosis and Hepatic Histological Features of Non-alcoholic Steatohepatitis.

Screening for therapeutic trials and treatment indication in clinical practice: MACK-3, a new blood test for the diagnosis of fibrotic NASH.

Severe Vitamin D Deficiency Is Not Associated with Liver Damage in Morbidly Obese Patients.

Severe Vitamin D Deficiency May be an Additional Cofactor for the Occurrence of Alcoholic Steatohepatitis

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis

The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH

The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis

Therapeutic potential of nicotinamide adenine dinucleotide for nonalcoholic fatty liver disease

Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis

Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production

[Metabolic fatty liver diseases: hepatic consequences of the metabolic syndrome]

[Obesity, diabetes and insulin resistance. Alterations of insulin signalling]