List of works - Claudio Palomo

(1R)-(+)-camphor and acetone derived alpha'-hydroxy enones in asymmetric Diels-Alder reaction: catalytic activation by Lewis and Brønsted acids, substrate scope, applications in syntheses, and mechanistic studies

scientific article published in March 2010

1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis

scientific article

A 4-hydroxypyrrolidine-catalyzed mannich reaction of aldehydes: control of anti-selectivity by hydrogen bonding assisted by Brønsted acids.

scientific article published in May 2010

A Concise beta-Lactam Route to Short Peptide Segments Containing beta,beta-Disubstituted beta-Amino Acids

scientific article published on 01 April 1998

A beta-lactam-based stereoselective access to beta,gamma-dihydroxy alpha-amino acid-derived peptides with either alpha,beta-like or unlike configurations.

scientific article published in June 2001

A chiral acrylate equivalent for metal-free Diels-Alder reactions: endo-2-acryloylisoborneol

scientific article published in September 2002

A concise synthesis of α-amino acid N-carboxy anhydrides of (2S,3S)-β-substituted serines

A practical total synthesis of hapalosin, a 12-membered cyclic depsipeptide with multidrug resistance-reversing activity, by employing improved segment coupling and macrolactonization

scientific article

A strategy for the asymmetric aminohomologation of alpha, beta-dihydroxy aldehydes: application to the synthesis of the southwest tripeptide segment of echinocandin B.

scientific article

Alkylation of chiral alpha-hydroxy ketones derived from (1R)-(+)-camphor. An asymmetric variant of the classical acetylene route to carbonyl compounds

scientific article published on 01 October 2001

Alpha'-hydroxy enones as achiral templates for Lewis acid-catalyzed enantioselective Diels-Alder reactions

scientific article published in November 2003

Alpha,alpha-diarylprolinol ethers: new tools for functionalization of carbonyl compounds.

scientific article published on June 2008

Asymmetric Assembly of All-Carbon Tertiary/Quaternary Nonadjacent Stereocenters through Organocatalytic Conjugate Addition of α-Cyanoacetates to a Methacrylate Equivalent.

scientific article published on 3 August 2016

Asymmetric Synthesis of Adjacent Tri- and Tetrasubstituted Carbon Stereocenters: Organocatalytic Aldol Reaction of an Hydantoin Surrogate with Azaarene 2-Carbaldehydes

scientific article published on 03 September 2019

Asymmetric aza-Henry reaction under phase transfer catalysis: an experimental and theoretical study

scientific article published on 30 May 2008

Asymmetric synthesis of beta-mercapto carboxylic acid derivatives by intramolecular sulfur transfer in N-enoyl oxazolidine-2-thiones promoted by Lewis acids

scientific article published on 01 June 2001

Asymmetric synthesis of α-keto β-lactams via [2+2] cycloaddition reaction: A concise approach to optically active (α-hydroxy β-lactams and β-alkyl(aryl)isoserines

Base-Catalyzed Asymmetric α-Functionalization of 2-(Cyanomethyl)azaarene N-Oxides Leading to Quaternary Stereocenters

scientific article published on 3 March 2016

Bifunctional Brønsted Base Catalyst Enables Regio-, Diastereo-, and Enantioselective Cα -Alkylation of β-Tetralones and Related Aromatic-Ring-Fused Cycloalkanones.

scientific article published on 18 January 2017

Bifunctional Brønsted Base Catalyzed Mannich Reaction of β-Alkoxy α-Keto Amides: Stereocontrolled Entry to Functionalized Amino Diols

scientific article published on 23 July 2018

Bifunctional Brønsted Base Catalyzes Direct Asymmetric Aldol Reaction of α-Keto Amides

scientific article published on 02 February 2016

Brønsted Base Catalyzed One-Pot Synthesis of Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition

scientific article published on 30 August 2019

Camphor-based alpha-bromo ketones for the asymmetric darzens reaction

scientific article published on 01 December 2000

Catalytic Enantioselective Synthesis of N,C(α),C(α)-Trisubstituted α-Amino Acid Derivatives Using 1H-Imidazol-4(5H)-ones as Key Templates.

scientific article

Catalytic Michael reactions of ketoesters with a camphor-derived acrylate equivalent: stereoselective access to all-carbon quaternary centers

scientific article published on 03 June 2008

Catalytic asymmetric synthesis of γ-substituted vinyl sulfones

scientific article published on 19 January 2011

Catalytic conjugate additions of geminal bis(sulfone)s: expanding the chemistry of sulfones as simple alkyl anion equivalents.

scientific article published in November 2009

Catalytic enantioselective Mannich-type reaction with beta-phenyl sulfonyl acetonitrile

scientific article published in June 2010

Catalytic enantioselective aza-Henry reaction with broad substrate scope.

scientific article

Catalytic enantioselective conjugate addition of carbamates

scientific article published on 01 August 2004

Catalytic enantioselective quick route to aldol-tethered 1,6- and 1,7-enynes from ω-unsaturated aldehydes.

scientific article published on 3 October 2014

Catalytic enantioselective synthesis of tertiary thiols from 5H-thiazol-4-ones and nitroolefins: bifunctional ureidopeptide-based Brønsted base catalysis

scientific article published on 17 September 2013

Chirality-driven folding of short β-lactam pseudopeptides

scientific article published on 13 December 2012

Conjugate addition of nitroalkanes to an acrylate equivalent. Stereocontrol at C-alpha of the nitro group through double catalytic activation

scientific article published on 01 September 2009

Construction of C--S bonds with a quaternary stereocenter through a formal michael reaction: asymmetric synthesis of tertiary thiols

scientific article published on 01 June 2004

Construction of Quaternary Stereogenic Centers via [2 + 2] Cycloaddition Reactions. Synthesis of Homochiral 4,4-Disubstituted 2-Azetidinones and Imine Substituent Effects on beta-Lactam Formation

scientific article published on 01 April 1997

Controlling the α/γ-Reactivity of Vinylogous Ketone Enolates in Organocatalytic Enantioselective Michael Reactions.

scientific article published on 30 May 2017

Copper-catalyzed enantioselective conjugate addition of dialkylzinc reagents to alpha'-oxy enones

scientific article published on 01 January 2008

Cyanoalkylation: Alkylnitriles in Catalytic C-C Bond-Forming Reactions.

scientific article published on 21 September 2015

Cyclic RGD β-Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells

article

Design and synthesis of a novel class of sugar-peptide hybrids: C-linked glyco beta-amino acids through a stereoselective "acetate" Mannich reaction as the key strategic element

scientific article

Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin

scientific article

Development of a syn-Selective Mannich Reaction of Aldehydes with Propargylic Imines by Dual Catalysis: Asymmetric Synthesis of Functionalized Propargylic Amines

scientific article published on 13 April 2016

Diarylprolinol ethers: expanding the potential of enamine/iminium-ion catalysis

scientific article published on 01 December 2006

Diastereoselective Conjugate Reduction and Enolate Trapping with Glyoxylate Imines. A Concise Approach to beta-Lactams that Involves a Ternary Combination of Components

scientific article published on 01 March 1999

Diastereoselective [2 + 2] cycloaddition of dichloroketene with α-oxyaldehydes and α-amino aldehydes

Enantio- and diastereoselective organocatalytic α-alkylation of aldehydes with 3-substituted 2-(bromomethyl)acrylates

scientific article published on 14 December 2011

Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Brønsted Base/H-Bonding Catalysis

scientific article published on 27 February 2019

Enantioselective Synthesis of 5,5-Disubstituted Hydantoins by Brønsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template.

scientific article published on 25 March 2018

Enantioselective Synthesis of Quaternary Δ4 - and Δ5 -Dehydroprolines Based on a Two-Step Formal [3+2] Cycloaddition of α-Aryl and α-Alkyl Isocyano(thio)acetates with Vinyl Ketones.

scientific article published on 28 July 2017

Enantioselective aza-Henry reactions assisted by Zn(II) and N-methylephedrine.

scientific article

Enantioselective construction of tetrasubstituted stereogenic carbons through Brønsted base catalyzed michael reactions: α'-hydroxy enones as key enoate equivalent

scientific article published on 09 December 2014

Enantioselective henry reactions under dual Lewis acid/amine catalysis using chiral amino alcohol ligands

scientific article published on 01 June 2005

From beta-lactams to alpha- and beta-amino acid derived peptides.

scientific article

Functionalization ofN-[(Silyl)methyl]-β-lactam Carbanions with Carbon Electrophiles

scientific article published on 01 August 2006

Generation of Threonine- and Azathreonine N-Carboxy Anhydrides from alpha-Hydroxy beta-Lactams Promoted by 2,2,6,6-Tetramethylpiperidinyl-1-oxyl (TEMPO) in Combination with Sodium Hypochlorite

scientific article published on 01 June 1996

Highly Diastereoselective Aldol Reactions with Camphor-Based Acetate Enolate Equivalents

scientific article published on 01 October 1999

Highly efficient asymmetric michael addition of aldehydes to nitroalkenes catalyzed by a simple trans-4-hydroxyprolylamide

scientific article published on 01 September 2006

Highly enantioselective Friedel-Crafts alkylations of pyrroles and indoles with alpha'-hydroxy enones under Cu(II)-simple bis(oxazoline) catalysis.

scientific article published in March 2005

Highly enantioselective conjugate additions of aldehydes to vinyl sulfones

scientific article published on 01 January 2009

Intramolecular sulfur transfer in N-enoyl oxazolidine-2-thiones promoted by Brønsted acids. Practical asymmetric synthesis of beta-mercapto carboxylic acids and mechanistic insights

scientific article published on 01 November 2006

Lewis acid catalyzed asymmetric cycloadditions of nitrones: alpha'-hydroxy enones as efficient reaction partners

scientific article published on 01 September 2005

Mechanistic insights on the magnesium(II) ion-activated reduction of methyl benzoylformate with chelated NADH peptide beta-lactam models.

scientific article published in September 2009

N-(Diazoacetyl)oxazolidin-2-thiones as sulfur-donor reagents: asymmetric synthesis of thiiranes from aldehydes

scientific article published on 26 September 2012

New Approach to the Coupling of γ-Amino β-Hydroxy Acids and β,γ-Dihydroxy Acids with α-Amino Acid Esters

Practical Access to Carbacephem Intermediates via Asymmetric [2 + 2] Ketene-Imine Cycloaddition

scientific article published on 01 September 1998

Practical Synthesis of α-Amino AcidN-Carboxy Anhydrides of Polyhydroxylated α-Amino Acids from β-Lactam Frameworks. Model Studies toward the Synthesis of Directly Linked Peptidyl Nucleoside Antibiotics

article

Regio- and enantioselective direct oxyamination reaction of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether

scientific article published on 01 January 2007

Scavenging of fluorinated N,N'-dialkylureas by hydrogen binding: a novel separation method for fluorous synthesis

scientific article published on 01 July 2001

Simple access to the nonproteinogenic peptide fragments of lysobactin from azetidin-2-one frameworks

Strategy for Stereoselective Metal-free α-Functionalization of 2-Azaaryl Acetates with N-Boc Imines.

scientific article published on 4 September 2017

Synthesis of Type II β-Turn Surrogate Dipeptides Based onsyn-α-Amino-α,β-dialkyl-β-lactams

scientific article published on 01 November 2004

Synthesis of β-Lactam Scaffolds for Ditopic Peptidomimetics

scientific article published in 2007

Synthetic applications of chromium(VI) reagents in combination with chlorotrimethylsilane

The aldol addition reaction: an old transformation at constant rebirth

scientific article published on 01 January 2002

Towards Direct Mukaiyama‐Type Reactions Catalytic in Silicon ⬇️

scientific article published on 08 July 2011

Unveiling reliable catalysts for the asymmetric nitroaldol (Henry) reaction.

scientific article published in October 2004

Ureidopeptide-based Brønsted bases: design, synthesis and application to the catalytic enantioselective synthesis of β-amino nitriles from (arylsulfonyl)acetonitriles

scientific article published on 15 April 2014

Water-compatible iminium activation: organocatalytic Michael reactions of carbon-centered nucleophiles with enals

scientific article published in January 2007

alpha-Alkyl-alpha-Amino-beta-Lactam Peptides: Design, Synthesis, and Conformational Features.

scientific article

alpha-Oxymethyl Ketone Enolates for the Asymmetric Mannich Reaction. From Acetylene and N-Alkoxycarbonylimines to beta-Amino Acids This work was supported by the University of the Basque Country, the Basque Government (Projects UPV 170.215-G47/98, E

scientific article published on 01 March 2000

α-Branched Ketone Dienolates: Base-Catalysed Generation and Regio- and Enantioselective Addition Reactions

scientific article published on 03 July 2019

α-Hydroxy Ketones as Masked Ester Donors in Brønsted Base Catalyzed Conjugate Additions to Nitroalkenes

scientific article published on 15 February 2018

α-Hydroxy ketones as useful templates in asymmetric reactions.

scientific article published on 17 April 2012

β2, 2 -Amino Acid N-Carboxyanhydrides Relying on Sequential Enantioselective C(4)-Functionalization of Pyrrolidin-2,3-diones and Regioselective Baeyer-Villiger Oxidation

scientific article published on 28 February 2017

“Click” Saccharide/β-Lactam Hybrids for Lectin Inhibition

article

List of works by Claudio Palomo

(1R)-(+)-camphor and acetone derived alpha'-hydroxy enones in asymmetric Diels-Alder reaction: catalytic activation by Lewis and Brønsted acids, substrate scope, applications in syntheses, and mechanistic studies

1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis

A 4-hydroxypyrrolidine-catalyzed mannich reaction of aldehydes: control of anti-selectivity by hydrogen bonding assisted by Brønsted acids.

A Concise beta-Lactam Route to Short Peptide Segments Containing beta,beta-Disubstituted beta-Amino Acids

A beta-lactam-based stereoselective access to beta,gamma-dihydroxy alpha-amino acid-derived peptides with either alpha,beta-like or unlike configurations.

A chiral acrylate equivalent for metal-free Diels-Alder reactions: endo-2-acryloylisoborneol

A concise synthesis of α-amino acid N-carboxy anhydrides of (2S,3S)-β-substituted serines

A practical total synthesis of hapalosin, a 12-membered cyclic depsipeptide with multidrug resistance-reversing activity, by employing improved segment coupling and macrolactonization

A strategy for the asymmetric aminohomologation of alpha, beta-dihydroxy aldehydes: application to the synthesis of the southwest tripeptide segment of echinocandin B.

Alkylation of chiral alpha-hydroxy ketones derived from (1R)-(+)-camphor. An asymmetric variant of the classical acetylene route to carbonyl compounds

Alpha'-hydroxy enones as achiral templates for Lewis acid-catalyzed enantioselective Diels-Alder reactions

Alpha,alpha-diarylprolinol ethers: new tools for functionalization of carbonyl compounds.

Asymmetric Assembly of All-Carbon Tertiary/Quaternary Nonadjacent Stereocenters through Organocatalytic Conjugate Addition of α-Cyanoacetates to a Methacrylate Equivalent.

Asymmetric Synthesis of Adjacent Tri- and Tetrasubstituted Carbon Stereocenters: Organocatalytic Aldol Reaction of an Hydantoin Surrogate with Azaarene 2-Carbaldehydes

Asymmetric aza-Henry reaction under phase transfer catalysis: an experimental and theoretical study

Asymmetric synthesis of beta-mercapto carboxylic acid derivatives by intramolecular sulfur transfer in N-enoyl oxazolidine-2-thiones promoted by Lewis acids

Asymmetric synthesis of α-keto β-lactams via [2+2] cycloaddition reaction: A concise approach to optically active (α-hydroxy β-lactams and β-alkyl(aryl)isoserines

Base-Catalyzed Asymmetric α-Functionalization of 2-(Cyanomethyl)azaarene N-Oxides Leading to Quaternary Stereocenters

Bifunctional Brønsted Base Catalyst Enables Regio-, Diastereo-, and Enantioselective Cα -Alkylation of β-Tetralones and Related Aromatic-Ring-Fused Cycloalkanones.

Bifunctional Brønsted Base Catalyzed Mannich Reaction of β-Alkoxy α-Keto Amides: Stereocontrolled Entry to Functionalized Amino Diols

Bifunctional Brønsted Base Catalyzes Direct Asymmetric Aldol Reaction of α-Keto Amides

Brønsted Base Catalyzed One-Pot Synthesis of Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition

Camphor-based alpha-bromo ketones for the asymmetric darzens reaction

Catalytic Enantioselective Synthesis of N,C(α),C(α)-Trisubstituted α-Amino Acid Derivatives Using 1H-Imidazol-4(5H)-ones as Key Templates.

Catalytic Michael reactions of ketoesters with a camphor-derived acrylate equivalent: stereoselective access to all-carbon quaternary centers

Catalytic asymmetric synthesis of γ-substituted vinyl sulfones

Catalytic conjugate additions of geminal bis(sulfone)s: expanding the chemistry of sulfones as simple alkyl anion equivalents.

Catalytic enantioselective Mannich-type reaction with beta-phenyl sulfonyl acetonitrile

Catalytic enantioselective aza-Henry reaction with broad substrate scope.

Catalytic enantioselective conjugate addition of carbamates

Catalytic enantioselective quick route to aldol-tethered 1,6- and 1,7-enynes from ω-unsaturated aldehydes.

Catalytic enantioselective synthesis of tertiary thiols from 5H-thiazol-4-ones and nitroolefins: bifunctional ureidopeptide-based Brønsted base catalysis

Chirality-driven folding of short β-lactam pseudopeptides

Conjugate addition of nitroalkanes to an acrylate equivalent. Stereocontrol at C-alpha of the nitro group through double catalytic activation

Construction of C--S bonds with a quaternary stereocenter through a formal michael reaction: asymmetric synthesis of tertiary thiols

Construction of Quaternary Stereogenic Centers via [2 + 2] Cycloaddition Reactions. Synthesis of Homochiral 4,4-Disubstituted 2-Azetidinones and Imine Substituent Effects on beta-Lactam Formation

Controlling the α/γ-Reactivity of Vinylogous Ketone Enolates in Organocatalytic Enantioselective Michael Reactions.

Copper-catalyzed enantioselective conjugate addition of dialkylzinc reagents to alpha'-oxy enones

Cyanoalkylation: Alkylnitriles in Catalytic C-C Bond-Forming Reactions.

Cyclic RGD β-Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells

Design and synthesis of a novel class of sugar-peptide hybrids: C-linked glyco beta-amino acids through a stereoselective "acetate" Mannich reaction as the key strategic element

Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin

Development of a syn-Selective Mannich Reaction of Aldehydes with Propargylic Imines by Dual Catalysis: Asymmetric Synthesis of Functionalized Propargylic Amines

Diarylprolinol ethers: expanding the potential of enamine/iminium-ion catalysis

Diastereoselective Conjugate Reduction and Enolate Trapping with Glyoxylate Imines. A Concise Approach to beta-Lactams that Involves a Ternary Combination of Components

Diastereoselective [2 + 2] cycloaddition of dichloroketene with α-oxyaldehydes and α-amino aldehydes

Enantio- and diastereoselective organocatalytic α-alkylation of aldehydes with 3-substituted 2-(bromomethyl)acrylates

Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Brønsted Base/H-Bonding Catalysis

Enantioselective Synthesis of 5,5-Disubstituted Hydantoins by Brønsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template.

Enantioselective Synthesis of Quaternary Δ4 - and Δ5 -Dehydroprolines Based on a Two-Step Formal [3+2] Cycloaddition of α-Aryl and α-Alkyl Isocyano(thio)acetates with Vinyl Ketones.

Enantioselective aza-Henry reactions assisted by Zn(II) and N-methylephedrine.

Enantioselective construction of tetrasubstituted stereogenic carbons through Brønsted base catalyzed michael reactions: α'-hydroxy enones as key enoate equivalent

Enantioselective henry reactions under dual Lewis acid/amine catalysis using chiral amino alcohol ligands

From beta-lactams to alpha- and beta-amino acid derived peptides.

Functionalization ofN-[(Silyl)methyl]-β-lactam Carbanions with Carbon Electrophiles

Generation of Threonine- and Azathreonine N-Carboxy Anhydrides from alpha-Hydroxy beta-Lactams Promoted by 2,2,6,6-Tetramethylpiperidinyl-1-oxyl (TEMPO) in Combination with Sodium Hypochlorite

Highly Diastereoselective Aldol Reactions with Camphor-Based Acetate Enolate Equivalents

Highly efficient asymmetric michael addition of aldehydes to nitroalkenes catalyzed by a simple trans-4-hydroxyprolylamide

Highly enantioselective Friedel-Crafts alkylations of pyrroles and indoles with alpha'-hydroxy enones under Cu(II)-simple bis(oxazoline) catalysis.

Highly enantioselective conjugate additions of aldehydes to vinyl sulfones

Intramolecular sulfur transfer in N-enoyl oxazolidine-2-thiones promoted by Brønsted acids. Practical asymmetric synthesis of beta-mercapto carboxylic acids and mechanistic insights

Lewis acid catalyzed asymmetric cycloadditions of nitrones: alpha'-hydroxy enones as efficient reaction partners

Mechanistic insights on the magnesium(II) ion-activated reduction of methyl benzoylformate with chelated NADH peptide beta-lactam models.

N-(Diazoacetyl)oxazolidin-2-thiones as sulfur-donor reagents: asymmetric synthesis of thiiranes from aldehydes

New Approach to the Coupling of γ-Amino β-Hydroxy Acids and β,γ-Dihydroxy Acids with α-Amino Acid Esters

Practical Access to Carbacephem Intermediates via Asymmetric [2 + 2] Ketene-Imine Cycloaddition

Practical Synthesis of α-Amino AcidN-Carboxy Anhydrides of Polyhydroxylated α-Amino Acids from β-Lactam Frameworks. Model Studies toward the Synthesis of Directly Linked Peptidyl Nucleoside Antibiotics

Regio- and enantioselective direct oxyamination reaction of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether

Scavenging of fluorinated N,N'-dialkylureas by hydrogen binding: a novel separation method for fluorous synthesis

Simple access to the nonproteinogenic peptide fragments of lysobactin from azetidin-2-one frameworks

Strategy for Stereoselective Metal-free α-Functionalization of 2-Azaaryl Acetates with N-Boc Imines.

Synthesis of Type II β-Turn Surrogate Dipeptides Based onsyn-α-Amino-α,β-dialkyl-β-lactams

Synthesis of β-Lactam Scaffolds for Ditopic Peptidomimetics

Synthetic applications of chromium(VI) reagents in combination with chlorotrimethylsilane

The aldol addition reaction: an old transformation at constant rebirth

Towards Direct Mukaiyama‐Type Reactions Catalytic in Silicon ⬇️

Unveiling reliable catalysts for the asymmetric nitroaldol (Henry) reaction.

Ureidopeptide-based Brønsted bases: design, synthesis and application to the catalytic enantioselective synthesis of β-amino nitriles from (arylsulfonyl)acetonitriles

Water-compatible iminium activation: organocatalytic Michael reactions of carbon-centered nucleophiles with enals