List of works - Douglas B. Kitchen

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

scientific article

5-Functionalized indazoles as glucocorticoid receptor agonists

scientific article published on 11 April 2010

Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

scientific article published on 16 July 2015

Computational approaches for modeling human intestinal absorption and permeability.

scientific article published on April 2006

Computational models to predict blood-brain barrier permeation and CNS activity

scientific article published on 01 October 2003

Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

scientific article published on 05 November 2010

Design, selection, and evaluation of a general kinase-focused library

scientific article published in August 2009

Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease

scientific article

Determining local conformational variations in DNA. Nuclear magnetic resonance structures of the DNA duplexes d(CGCCTAATCG) and d(CGTCACGCGC) generated using back-calculation of the nuclear Overhauser effect spectra, a distance geometry algorithm an

scientific article published in August 1990

Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design

scientific article

Early phase drug discovery: cheminformatics and computational techniques in identifying lead series

scientific article

Homology model for oncostatin M based on NMR structural data.

scientific article

Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)

scientific article published on 01 April 1999

Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.

scientific article

Median Partitioning: a novel method for the selection of representative subsets from large compound pools

scientific article published in July 2002

Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

scientific article published on 23 September 2015

Molecular dynamics simulation of solvated protein at high pressure

scientific article

Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor.

scientific article published on April 1997

Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations

scientific article published on 4 November 2015

The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism

scientific article (publication date: 2011)

The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties

scientific article published on 28 April 2014

List of works by Douglas B. Kitchen

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

5-Functionalized indazoles as glucocorticoid receptor agonists

Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

Computational approaches for modeling human intestinal absorption and permeability.

Computational models to predict blood-brain barrier permeation and CNS activity

Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Design, selection, and evaluation of a general kinase-focused library

Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease

Determining local conformational variations in DNA. Nuclear magnetic resonance structures of the DNA duplexes d(CGCCTAATCG) and d(CGTCACGCGC) generated using back-calculation of the nuclear Overhauser effect spectra, a distance geometry algorithm an

Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design

Early phase drug discovery: cheminformatics and computational techniques in identifying lead series

Homology model for oncostatin M based on NMR structural data.

Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)

Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.

Median Partitioning: a novel method for the selection of representative subsets from large compound pools

Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Molecular dynamics simulation of solvated protein at high pressure

Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor.

Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations

The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism

The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties