List of works - Andrew Sutherland

A Tandem Aza-Claisen Rearrangement and Ring Closing Metathesis Reaction for the Synthesis of Cyclic Allylic Trichloroacetamides

scientific article published on 09 November 2007

A facile synthesis of (S)-gizzerosine, a potent agonist of the histamine H2-receptor

A flexible approach for the synthesis of selectively labelled l -arginine

A highly efficient, asymmetric synthesis of blastidic acid: the β-amino acid component of the antibiotic, (+)-blasticidin S

A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement

scientific article published on 07 February 2005

A new general approach for the stereocontrolled synthesis of functionalised γ- and δ-lactams

article

A novel 18F-labelled high affinity agent for PET imaging of the translocator protein

scientific article published on 27 May 2015

A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents.

scientific article

A one-pot, reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids

scientific article published on 13 May 2011

A one-pot, three-step process for the diastereoselective synthesis of aminobicyclo[4.3.0]nonanes using consecutive palladium(II)- and ruthenium(II)-catalysis

scientific article

A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction.

scientific article

A stereoselective synthesis of (2R,3S)-2-amino-3,4-dihydroxybutyric acid using an ether directed aza-Claisen rearrangement

A tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one of defined relative stereochemistry for use towards Agariblazeispirol C

article

A three-step tandem process for the synthesis of bicyclic γ-lactams

scientific article published on 28 May 2010

Access to 2,6-Disubstituted 4-Oxopiperidines Using a 6-Endo-trig Cyclization: Stereoselective Synthesis of Spruce Alkaloid and (+)-241D.

scientific article

An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent.

scientific article

Asymmetric Synthesis of Pipecolic Acid and Derivatives

Asymmetric synthesis of allylic secondary alcohols: a new general approach for the preparation of α-amino acids

Asymmetric synthesis of cis-aminocyclopentenols, building blocks for medicinal chemistry.

scientific article published in February 2014

Bacterial diaminopimelate metabolism as a target for antibiotic design.

scientific article published in May 2000

Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence

scientific article published on 20 January 2020

Conjugate addition of radicals generated from diacyloxyiodobenzenes to dehydroamino acid derivatives; a synthesis of diaminopimelic acid analogues

scientific article

Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.

scientific article published on 16 July 2009

Development of the radiosynthesis of high-specific-activity 123I-NKJ64

article

Diastereoselective synthesis of highly substituted polycyclic scaffolds via a one-pot four-step tandem catalytic process

article by Mark W. Grafton et al published October 2014 in Tetrahedron

Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds

article by Mark W. Grafton et al published 2012 in Chemical Communications

Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase

scientific article

Enantioselective Synthesis of 3-Methyleneindan-1-ols via a One-Pot Allylboration–Heck Reaction of 2-Bromobenzaldehydes

scientific article published on 01 May 2015

Enantioselective syntheses of α-amino-β-hydroxy acids, and [15N]-L-threonine

Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect

scholarly article by Andrew G. Jamieson & Andrew Sutherland published March 2007 in Tetrahedron

Ether-directed, stereoselective aza-Claisen rearrangements: synthesis of the piperidine alkaloid, alpha-conhydrine

scientific article published on 20 March 2007

Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide

scientific article published on 01 October 2015

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scientific article published on 01 February 2020

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scientific article published on 01 December 2019

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scientific article published on 14 April 2020

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scientific article published on 23 July 2019

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scientific article published on 15 June 2020

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scientific article published on 12 August 2020

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scientific article published on 08 October 2020

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scientific article published on 09 December 2020

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scientific article published on 01 June 2016

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article published in 2007

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scientific article published on 20 September 2019

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scientific article published on 01 April 2018

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scientific article published on 01 June 2017

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article published in 2014

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scientific article published on 01 June 2013

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Identification of Active Site Cysteine Residues that Function as General Bases: Diaminopimelate Epimerase

article

Intermolecular Aryl C-H Amination through Sequential Iron and Copper Catalysis.

scientific article published on 5 December 2016

Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography

scientific article

Iron(III)-Catalyzed Chlorination of Activated Arenes

scientific article published on 29 June 2017

Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer

scientific article published on 31 May 2019

Late stage iodination of biologically active agents using a one-pot process from aryl amines

scholarly article in RSC Advances, vol. 7 no. 86, 2017

Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

article

Mechanism of Cu-Catalyzed Aryl Boronic Acid Halodeboronation Using Electrophilic Halogen: Development of a Base-Catalyzed Iododeboronation for Radiolabeling Applications

scientific article published on 25 March 2019

Microwave-promoted tandem reactions for the synthesis of bicyclic γ-lactams

Molecular tracers for the PET and SPECT imaging of disease

scientific article published on September 2010

Multibond Forming Tandem Reactions of Anilines via Stable Aryl Diazonium Salts: One-Pot Synthesis of 3,4-Dihydroquinolin-2-ones

New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors

scholarly article by Roland Bischoff et al published 2007 in Journal of Labelled Compounds and Radiopharmaceuticals

New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein

scientific article

New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter

scientific article published on 19 August 2008

Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides

scientific article

Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging

scientific article published on 18 June 2013

One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Brønsted Acid and Palladium Catalysis.

scientific article published on 6 October 2017

One-Pot Multi-Reaction Processes: Synthesis of Natural Products and Drug-Like Scaffolds

One-Pot Synthesis of 5-Amino-2,5-dihydro-1-benzoxepines: Access to Pharmacologically Active Heterocyclic Scaffolds

scientific article published on 13 April 2015

One-pot ortho-amination of aryl C-H bonds using consecutive iron and copper catalysis

scientific article published on 01 May 2019

Palladium(II)-Catalysed Rearrangement Reactions

Preparation of Amino-Substituted Indenes and 1,4-Dihydronaphthalenes Using a One-Pot Multireaction Approach: Total Synthesis of Oxybenzo[c]phenanthridine Alkaloids

scientific article published on 01 August 2014

Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-sphinganine, (+)-spisulosine, and D-ribo-phytosphingosine.

scientific article published on 3 July 2013

Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes.

scientific article published on 6 November 2017

Rapid and efficient radiosynthesis of [123I]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors

scientific article published on 2 May 2008

Recent Advances in Synthetic Methods for Radioiodination

scientific article published on 05 May 2020

Recent Advances in Transition-Metal-Catalyzed Iodination of Arenes

article published in 2016

Recent Advances in Transition-Metal-Catalyzed, Directed Aryl C–H/N–H Cross-Coupling Reactions

Recent advances in the synthesis and application of fluorescent α-amino acids

scientific article

Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents.

scientific article published on 30 June 2006

Silver(I)-Catalyzed Iodination of Arenes: Tuning the Lewis Acidity of N-Iodosuccinimide Activation

scientific article published on 25 January 2016

Spectroscopic Characterization of Model Compounds, Reactants, and Byproducts Connected with an Isocyanate Production Chain

Stereocontrol of palladium(ii)-catalysed aza-Claisen rearrangements using a combination of 1,3-allylic strain and a solvent mediated directing effect

scientific article published on 28 September 2006

Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement

scientific article

Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter

scientific article published on 30 April 2008

Stereoselective synthesis of 2,6-trans-4-oxopiperidines using an acid-mediated 6-endo-trig cyclisation

scientific article published on 01 September 2018

Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton

Stereoselective synthesis of hydroxylated 3-aminoazepanes using a multi-bond forming, three-step tandem process

scientific article published on 01 October 2012

Stereoselective synthesis of polyhydroxylated aminocyclohexanes

scientific article published on 02 March 2011

Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin

scientific article published on 10 August 2010

Structural diversification of the aminobicyclo[4.3.0]nonane skeleton using alkynylsilyl-derived allylic trichloroacetimidates

scientific article

Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target

scholarly article

Structure–activity relationships of novel iodinated quinoline-2-carboxamides for targeting the translocator protein

article published in 2013

Studies on the aza-Claisen rearrangement of 4,5-dihydroxylated allylic trichloroacetimidates: the stereoselective synthesis of (2R,3S)- and (2S,3S)-2-amino-3,4-dihydroxybutyric acids

Switching the Stereochemical Outcome of 6-Endo-Trig Cyclizations; Synthesis of 2,6-Cis-6-Substituted 4-Oxopipecolic Acids

Syntheses of isotopically labelled L-α-amino acids with an asymmetric centre at C-3

Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo

scientific article published on 15 October 2015

Synthesis and Fluorescent Properties of β-Pyridyl α-Amino Acids

scientific article published on 15 February 2019

Synthesis and Photophysical Properties of Benzotriazole-Derived Unnatural α-Amino Acids

scientific article published on 07 August 2019

Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.

scientific article

Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor

Synthesis and enzyme-catalysed reductions of 2-oxo acids with oxygen containing side-chains

Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity

scientific article

Synthesis and reactivity of 4-oxo-5-trimethylsilanyl derived α-amino acids

Synthesis of 5-Amino-2,5-dihydro-1H-benzo[b]azepines Using a One-Pot Multibond Forming Process

scientific article published on 21 July 2016

Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells

scientific article

Synthesis of Benzo[b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis

scientific article published on 18 March 2020

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

scientific article published on 19 December 2018

Synthesis of Isotopically Labeled α-Amino Acids

Synthesis of amino-substituted indanes and tetralins via consecutive multibond-forming tandem processes

scientific article

Synthesis of fluorescent enone derived alpha-amino acids

scientific article published on 18 August 2009

Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

scientific article published on 14 September 2008

Synthesis of probes for the active site of leucine dehydrogenase

scientific article published on 01 July 1999

Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones

article

Synthesis of the isoquinoline alkaloid, crispine C

Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165.

scientific article

Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles

scientific article published on 26 September 2007

Tandem aza-Claisen rearrangement and ring-closing metathesis reactions: the stereoselective synthesis of functionalised carbocyclic amides

The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement

scientific article published on 19 February 2004

The first isolation of an alkoxy-N,N-dialkylaminodifluorosulfane from the reaction of an alcohol and DAST: an efficient synthesis of (2S,3R,6S)-3-fluoro-2,6-diaminopimelic acid

The first stereospecific synthesis of l-tetrahydrodipicolinic acid†; a key intermediate of diaminopimelate metabolism

The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase

scientific article published on 15 November 2005

Total synthesis of clavaminol A, C and H

scientific article published on 30 August 2011

Unsaturated α-aminopimelic acids as potent inhibitors of meso-diaminopimelic acid (DAP) D-dehydrogenase

Versatile synthesis of 3,5-disubstituted 2-fluoropyridines and 2-pyridones

scientific article published in April 2003

Walleminol and walleminone, novel caryophyllenes from the toxigenic fungus Wallemia sebi

article

¹²³I-NKJ64: a novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain

scientific article published on 10 March 2011

List of works by Andrew Sutherland

A Tandem Aza-Claisen Rearrangement and Ring Closing Metathesis Reaction for the Synthesis of Cyclic Allylic Trichloroacetamides

A facile synthesis of (S)-gizzerosine, a potent agonist of the histamine H2-receptor

A flexible approach for the synthesis of selectively labelled l -arginine

A highly efficient, asymmetric synthesis of blastidic acid: the β-amino acid component of the antibiotic, (+)-blasticidin S

A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement

A new general approach for the stereocontrolled synthesis of functionalised γ- and δ-lactams

A novel 18F-labelled high affinity agent for PET imaging of the translocator protein

A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents.

A one-pot, reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids

A one-pot, three-step process for the diastereoselective synthesis of aminobicyclo[4.3.0]nonanes using consecutive palladium(II)- and ruthenium(II)-catalysis

A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction.

A stereoselective synthesis of (2R,3S)-2-amino-3,4-dihydroxybutyric acid using an ether directed aza-Claisen rearrangement

A tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one of defined relative stereochemistry for use towards Agariblazeispirol C

A three-step tandem process for the synthesis of bicyclic γ-lactams

Access to 2,6-Disubstituted 4-Oxopiperidines Using a 6-Endo-trig Cyclization: Stereoselective Synthesis of Spruce Alkaloid and (+)-241D.

An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent.

Asymmetric Synthesis of Pipecolic Acid and Derivatives

Asymmetric synthesis of allylic secondary alcohols: a new general approach for the preparation of α-amino acids

Asymmetric synthesis of cis-aminocyclopentenols, building blocks for medicinal chemistry.

Bacterial diaminopimelate metabolism as a target for antibiotic design.

Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence

Conjugate addition of radicals generated from diacyloxyiodobenzenes to dehydroamino acid derivatives; a synthesis of diaminopimelic acid analogues

Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.

Development of the radiosynthesis of high-specific-activity 123I-NKJ64

Diastereoselective synthesis of highly substituted polycyclic scaffolds via a one-pot four-step tandem catalytic process

Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds

Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase

Enantioselective Synthesis of 3-Methyleneindan-1-ols via a One-Pot Allylboration–Heck Reaction of 2-Bromobenzaldehydes

Enantioselective syntheses of α-amino-β-hydroxy acids, and [15N]-L-threonine

Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect

Ether-directed, stereoselective aza-Claisen rearrangements: synthesis of the piperidine alkaloid, alpha-conhydrine

Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide

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