List of works - Jonathan Schisler

A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.

scientific article published on July 2012

ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF

scientific article

Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP

article

All the Little Pieces - Regulation of Mitochondrial Fusion and Fission by Ubiquitin and Small Ubiquitin-Like Modifier and Their Potential Relevance in the Heart - ⬇️

scientific article published on October 15, 2011

An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans

scientific article published on September 2004

Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP.

scientific article published on 23 April 2018

Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease.

scientific article published on January 2008

Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.

scientific article published on 30 April 2018

Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP

scientific article

BMPER regulates cardiomyocyte size and vessel density in vivo ⬇️

scientific article published on November 28, 2012

Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding

scientific article published on 23 January 2017

Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.

scientific article

Brothers and sisters: molecular insights into arterial-venous heterogeneity

scientific article published on October 2008

Build it up-Tear it down: protein quality control in the cardiac sarcomere

scientific article published on 29 October 2008

CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis

scientific article

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

scientific article published on 20 October 2020

CHIP protects against cardiac pressure overload through regulation of AMPK ⬇️

scientific article published on July 25, 2013

Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin.

scientific article published on 24 February 2015

Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo

scientific article published on 04 June 2009

Cardio-metabolic effectsof HIV protease inhibitors (lopinavir/ritonavir)

scientific article

Changes in protein function underlie the disease spectrum in patients with CHIP mutations

scientific article published on 16 October 2019

Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.

scientific article published on 15 November 2017

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

scientific article

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

scientific article published in 2023

Correction: Cardio-Metabolic Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir).

scientific article published on 26 November 2013

Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates.

scientific article

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

scientific article published on 17 September 2018

Emerging evidence of coding mutations in the ubiquitin-proteasome system associated with cerebellar ataxias

scientific article published on 23 October 2014

Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions

scientific article published on April 2015

Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.

scientific article published on 29 October 2015

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

scientific article

Global gene expression profiling of a mouse model of ovarian clear cell carcinoma caused by ARID1A and PIK3CA mutations implicates a role for inflammatory cytokine signaling.

scientific article

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo.

scientific article published on 23 April 2016

Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo

scientific article published on 23 May 2018

Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library

scientific article

MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

scientific article published in February 2006

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes

scientific article

Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart.

scientific article published on 16 December 2009

Minireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system

scientific article

Modeling the Transition From Decompensated to Pathological Hypertrophy.

scientific article

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

scientific article published on 5 August 2015

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.

scientific article published on 28 July 2015

New insights into bone morphogenetic protein signaling: focus on angiogenesis

scientific article published on May 2009

Non-radiometric Cell-free Assay to Measure the Effect of Molecular Chaperones on AMP-Activated Kinase Activity

scientific article published on 01 April 2019

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

scientific article

Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

scientific article published on 12 August 2013

Regulation of AMPK by the ubiquitin proteasome system

scientific article

SKELETAL MUSCLE MITOCHONDRIAL ALTERATIONS IN CARBOXYL TERMINUS OF HSC70 INTERACTING PROTEIN (CHIP) -/- MICE

Seek and destroy: the ubiquitin----proteasome system in cardiac disease.

scientific article published on December 2009

Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry

scientific article

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1

scientific article

TAS2R38 Predisposition to Bitter Taste Associated with Differential Changes in Vegetable Intake in Response to a Community-Based Dietary Intervention.

scientific article

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

scientific article

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

scientific article published on 25 June 2015

Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males

scientific article

Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function

scientific article

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

scientific article published on 08 April 2022

Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities

scientific article published on August 2016

Using community-based participatory research principles to develop more understandable recruitment and informed consent documents in genomic research

scientific article published on 4 May 2015

mTORtuous effect on the elastic heart

scientific article published on July 2015

List of works by Jonathan Schisler

A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.

ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF

Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP

All the Little Pieces - Regulation of Mitochondrial Fusion and Fission by Ubiquitin and Small Ubiquitin-Like Modifier and Their Potential Relevance in the Heart - ⬇️

An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans

Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP.

Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease.

Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.

Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP

BMPER regulates cardiomyocyte size and vessel density in vivo ⬇️

Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding

Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.

Brothers and sisters: molecular insights into arterial-venous heterogeneity

Build it up-Tear it down: protein quality control in the cardiac sarcomere

CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

CHIP protects against cardiac pressure overload through regulation of AMPK ⬇️

Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin.

Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo

Cardio-metabolic effectsof HIV protease inhibitors (lopinavir/ritonavir)

Changes in protein function underlie the disease spectrum in patients with CHIP mutations

Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

Correction: Cardio-Metabolic Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir).

Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates.

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

Emerging evidence of coding mutations in the ubiquitin-proteasome system associated with cerebellar ataxias

Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions

Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

Global gene expression profiling of a mouse model of ovarian clear cell carcinoma caused by ARID1A and PIK3CA mutations implicates a role for inflammatory cytokine signaling.

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo.

Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo

Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library

MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes

Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart.

Minireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system

Modeling the Transition From Decompensated to Pathological Hypertrophy.

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.

New insights into bone morphogenetic protein signaling: focus on angiogenesis

Non-radiometric Cell-free Assay to Measure the Effect of Molecular Chaperones on AMP-Activated Kinase Activity

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

Regulation of AMPK by the ubiquitin proteasome system

SKELETAL MUSCLE MITOCHONDRIAL ALTERATIONS IN CARBOXYL TERMINUS OF HSC70 INTERACTING PROTEIN (CHIP) -/- MICE

Seek and destroy: the ubiquitin----proteasome system in cardiac disease.

Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1

TAS2R38 Predisposition to Bitter Taste Associated with Differential Changes in Vegetable Intake in Response to a Community-Based Dietary Intervention.

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males

Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities

Using community-based participatory research principles to develop more understandable recruitment and informed consent documents in genomic research

mTORtuous effect on the elastic heart