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List of works by Paraskevi Giannakakou

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

scientific article published in April 2003

A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model.

scientific article published on 11 July 2011

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.

scientific article

Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.

scientific article

CENP-E checks in microtubule-drug resistance

scientific article published on 15 April 2010

Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody.

scientific article

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

scientific article

Chemistry and biology of diazonamide A: second total synthesis and biological investigations

scientific article

Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow

scientific article (publication date: 2013)

Circulating tumor cells in prostate cancer diagnosis and monitoring: an appraisal of clinical potential.

scientific article

Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule

scientific article published on 01 January 1998

Decade in review-funding in cancer research: National Cancer Institute awards-a work in progress

scientific article published on 14 October 2014

Design, synthesis, and biological properties of highly potent epothilone B analogues

scientific article published on 01 August 2003

Discovery of a biologically active thiostrepton fragment.

scientific article

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.

scientific article published on 09 June 2008

ERG induces taxane resistance in castration-resistant prostate cancer

scientific article

Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells

scientific article

Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues

scientific article published on 31 January 2007

Exploitation of the HIF axis for cancer therapy

scientific article published on 29 July 2004

Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device

scientific article

HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors.

scientific article published on October 2009

Integrating image analysis algorithms in a web interface for the quantification of microtubule dynamics

scientific article

Isolation and characterization of circulating tumor cells in prostate cancer

scientific article

Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity

scientific article published in December 2005

Molecular design and chemical synthesis of a highly potent epothilone

scientific article

Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer

scientific article published in June 2000

Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second allele

scientific article published on 18 December 2005

Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure

scientific article

Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography.

scientific article published on July 2008

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

scientific article published on 01 January 2001

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).

scientific article published on September 1998

Targeting microtubules for cancer chemotherapy

scientific article

The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).

scientific article

The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression

scientific article published on 16 December 2009

The importance of p53 location: nuclear or cytoplasmic zip code?

scientific article published on December 2003

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

scientific article

Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation.

scientific article published on December 2003

Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents

scientific article published on 01 January 1997

β-1 tubulin R307H SNP alters microtubule dynamics and affects severity of a hereditary thrombocytopenia

scientific article

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