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List of works by Jose C. Perales

6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia

scientific article

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

scientific article (publication date: 3 April 2014)

A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis

scientific article

Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids.

scientific article published on 2 March 2013

Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation

scientific article published on 23 March 2005

Axon-mediated gene transfer of retinal ganglion cells in vivo

scientific article published in January 1997

Biological properties of poly-L-lysine-DNA complexes generated by cooperative binding of the polycation

scientific article published on 03 July 2001

Branched RNA: A New Architecture for RNA Interference ⬇️

scientific article published on March 6, 2011

Characterization of a new liver- and kidney-specific pfkfb3 isozyme that is downregulated by cell proliferation and dedifferentiation.

scientific article

Cholesteryl ester transfer activity in liver disease and cholestasis, and its relation with fatty acid composition of lipoprotein lipids

scientific article published on 01 April 1996

Copolymers of poly-L-lysine with serine and tryptophan form stable DNA vectors: implications for receptor-mediated gene transfer.

scientific article

Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

scientific article published on 2 November 2016

Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification.

scientific article

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

scientific article

Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.

scientific article published on April 1994

Fructose 1,6-bisphosphate prevented endotoxemia, macrophage activation, and liver injury induced by D-galactosamine in rats.

scientific article published in March 2006

Fructose 1,6-bisphosphate reduced TNF-alpha-induced apoptosis in galactosamine sensitized rat hepatocytes through activation of nitric oxide and cGMP production

scientific article

Functional characterization of the human mariner transposon Hsmar2

scientific article (publication date: 2013)

Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice.

scientific article published on November 2011

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake

scientific article

Gene transfer into hepatoma cell lines via the serpin enzyme complex receptor ⬇️

scientific article published on August 1, 1997

Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor

scientific article

Glutathione content and adaptation to endogenously induced energy depletion in Mv1Lu cells.

scientific article published on June 2004

Immunologic responses to gene transfer into mice via the polymeric immunoglobulin receptor

scientific article

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability

scientific article (publication date: 8 August 2014)

Neuronal Progenitor Maintenance Requires Lactate Metabolism and PEPCK-M-Directed Cataplerosis

scientific article published on December 2014

New antidepressant strategy based on acute siRNA silencing of 5-HT1A autoreceptors

scientific article published on 01 June 2012

Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.

scientific article published on 3 November 2005

Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain.

scientific article published on 6 November 2007

PEPCK-C reexpression in the liver counters neonatal hypoglycemia in Pck1 del/del mice, unmasking role in non-gluconeogenic tissues

scientific article published on 26 October 2016

PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis

scientific article

PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner

scientific article published on 07 January 2021

PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells

scientific article

Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice.

scientific article published on 28 April 2008

Pfkfb3 is transcriptionally upregulated in diabetic mouse liver through proliferative signals.

scientific article published on 18 July 2009

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M

scientific article published on 15 November 2019

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

scientific article

Receptor-mediated gene transfer into macrophages

scientific article

Receptor-mediated gene transfer vectors: progress towards genetic pharmaceuticals.

scientific article published on October 2003

Reduced milk triglycerides in mice lacking phosphoenolpyruvate carboxykinase in mammary gland adipocytes and white adipose tissue contribute to the development of insulin resistance in pups

scientific article published on 07 October 2009

Regulation of the phosphoenolpyruvate carboxykinase/human factor IX gene introduced into the livers of adult rats by receptor-mediated gene transfer.

scientific article published in August 1993

Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation

scientific article (publication date: 28 August 2003)

Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.

scientific article published on 2 October 2017

Safety-modified episomal vectors for human gene therapy.

scientific article

Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects.

scientific article published on 2 August 2011

Short-fiber protein of ad40 confers enteric tropism and protection against acidic gastrointestinal conditions.

scientific article published on 27 June 2013

Single-stranded DNA condensed with poly-L-lysine results in nanometric particles that are significantly smaller, more stable in physiological ionic strength fluids and afford higher efficiency of gene delivery than their double-stranded counterparts

scientific article published on 01 August 2002

Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo

scientific article

Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region.

scientific article

Stepwise synthesis of RNA conjugates carrying peptide sequences for RNA interference studies

scientific article published on 03 February 2009

Synthesis and in vitro inhibition properties of siRNA conjugates carrying acridine and quindoline moieties.

scientific article

Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations ⬇️

scientific article published on January 26, 2011

Synthesis of lipid-oligonucleotide conjugates for RNA interference studies.

scientific article

Synthesis of oligonucleotides carrying amino lipid groups at the 3'-end for RNA interference studies.

scientific article published on October 2010

The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche

scientific article published on 28 December 2012

Transfer of the human Alpha1-antitrypsin gene into pulmonary macrophages in vivo

scientific article published on 01 May 1998

Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease.

scientific article

p38α function in osteoblasts influences adipose tissue homeostasis.

scientific article published on 30 December 2014

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