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List of works by Atsushi Kato

1-O-Benzyl-2,3-O-iso-propyl-idene-6-O-tosyl-α-l-sorbo-furan-ose

scientific article published on 12 June 2013

2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease.

scientific article published on 21 April 2010

3-Fluoroazetidinecarboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar

scientific article published on 17 April 2015

3-Hydroxyazetidine carboxylic acids: non-proteinogenic amino acids for medicinal chemists

scientific article published on 06 March 2013

4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group

scientific article

6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology.

scientific article

A concise stereoselective synthesis of (-)-erycibelline

scientific article published on 23 September 2011

Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae).

scientific article published on August 2003

Alkaloids from the poisonous plant Ipomoea carnea: effects on intracellular lysosomal glycosidase activities in human lymphoblast cultures

scientific article

Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.

scientific article published on 21 August 2006

An approach to 8 stereoisomers of homonojirimycin from (D)-glucose via kinetic & thermodynamic azido-γ-lactones

scientific article

Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice

scientific article published on 01 March 1998

Asymmetric synthesis of the four possible fagomine isomers

scientific article published on 01 May 2003

Azetidine iminosugars from the cyclization of 3,5-di-O-triflates of α-furanosides and of 2,4-di-O-triflates of β-pyranosides derived from glucose

scientific article published on 05 April 2012

Biological activities of 3,4,5-trihydroxypiperidines and their N- and O-derivatives

scientific article published on 16 April 2018

Biological properties of D- and L-1-deoxyazasugars

scientific article

C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat

scientific article published on 5 June 2013

Calystegine B3 as a specific inhibitor for cytoplasmic alpha-mannosidase, Man2C1

scientific article published on 08 January 2011

Calystegine B4, a novel trehalase inhibitor from Scopolia japonica

scientific article published on 01 October 1996

Calystegins of Physalis alkekengi var. francheti (Solanaceae). Structure determination and their glycosidase inhibitory activities

scientific article published on April 1995

Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases

scientific article published on 29 March 2019

Characterizing the selectivity of ER α-glucosidase inhibitors.

scientific article published in July 2019

Concise synthesis of calystegines B2 and B3via intramolecular Nozaki-Hiyama-Kishi reaction

scientific article published on 10 May 2016

Corrected Structure of Natural Hyacinthacine C1 via Total Synthesis

scientific article published on 04 February 2019

Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal α-Glucosidases: Binding Conformation and Interaction for ntSI

scientific article published on 13 April 2015

Design of a New α-1--Alkyl-DAB Derivative Acting as a Pharmacological Chaperone for β-Glucocerebrosidase Using Ligand Docking and Molecular Dynamics Simulation

scientific article published on 18 October 2018

Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1

scientific article published on 03 November 2011

Dihydroxynortropane alkaloids from calystegine-producing plants

scientific article published in July 2001

Discovery of a Potent α-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry

scientific article published on 01 August 2018

Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation

scientific article published on 01 August 2018

Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.

scientific article published on 12 March 2014

Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease

scientific article published on 03 December 2015

Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases

scientific article

Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in db/db mice

scientific article published on 01 February 2014

Effects of the prostaglandin E1 analog limaprost on mechanical allodynia caused by chemotherapeutic agents in mice

scientific article published on 11 March 2009

Eight stereoisomers of homonojirimycin from D-mannose

scientific article published on 03 April 2012

Enzymatic synthesis of the glycosides of calystegines B1 and B2 and their glycosidase inhibitory activities

scientific article published on 01 November 1997

Epimerization of C5 of an N-hydroxypyrrolidine in the synthesis of swainsonine related iminosugars

scientific article published on 19 April 2016

Evaluation of amino acid-mustard transport as L-type amino acid transporter 1 (LAT1)-mediated alkylating agents.

scientific article

Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition

scientific article published on 12 February 2019

Fagomine isomers and glycosides from Xanthocercis zambesiaca.

scientific article

First total synthesis of (+)-broussonetine W: glycosidase inhibition of natural product & analogs

scientific article published on 17 May 2016

Fluorinated and Conformationally Fixed Derivatives of L-HomoDMDP: Synthesis and Glycosidase Inhibition

scientific article published on 6 May 2015

General synthesis and biological evaluation of alpha-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-alpha-C-glycosides).

scientific article

General synthesis of sugar-derived azepane nitrones: precursors of azepane iminosugars

scientific article published on 11 March 2013

Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes

scientific article published on 06 April 2019

Glucosylceramide mimics: highly potent GCase inhibitors and selective pharmacological chaperones for mutations associated with types 1 and 2 Gaucher disease.

scientific article published on 2 October 2013

Glycosidase inhibition by all 10 stereoisomeric 2,5-dideoxy-2,5-iminohexitols prepared from the enantiomers of glucuronolactone

scientific article published on 06 September 2012

Homonojirimycin Isomers and N-Alkylated Homonojirimycins: Structural and Conformational Basis of Inhibition of Glycosidases ⬇️

scientific article published on July 2, 1998

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes

scientific article

Iminosugars as therapeutic agents: recent advances and promising trends

scientific article

In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease

scientific article published on 01 November 2017

In vitro inhibition and intracellular enhancement of lysosomal α-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives

scientific article published in July 2000

In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

scientific article

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.

scientific article published on 02 March 2016

Inhibition of nonmammalian glycosidases by azetidine iminosugars derived from stable 3,5-di-O-triflates of pentoses

scientific article published on 10 October 2011

Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

scientific article published on 10 May 2007

Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo

scientific article published on 01 September 2006

Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice

scientific article published on 16 April 2009

Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors ⬇️

scientific article published on 9 January 2015

Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and β-alanine pyrrolidine amino acids

scientific article published on 11 May 2019

Iteamine, the first alkaloid isolated from Itea virginica L. inflorescence

scientific article published on 14 February 2014

L-DMDP, L-homoDMDP and their C-3 fluorinated derivatives: synthesis and glycosidase-inhibition

scientific article published on 18 March 2011

Looking-glass synergistic pharmacological chaperones: DGJ and L-DGJ from the enantiomers of tagatose

scientific article published on 11 July 2011

Mechanical allodynia induced by paclitaxel, oxaliplatin and vincristine: different effectiveness of gabapentin and different expression of voltage-dependent calcium channel alpha(2)delta-1 subunit

scientific article

Multivalency To Inhibit and Discriminate Hexosaminidases.

scientific article published on 26 May 2017

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

scientific article

NHC-mediated cross-coupling of sugar-derived cyclic nitrones with enals: general and efficient synthesis of polyhydroxylated pyrrolizidines and indolizidines

scientific article published on 07 June 2013

New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii

scientific article published in February 2002

Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors

scientific article published on 07 April 2014

Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis

scientific article published on 01 May 1998

Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae). ⬇️

scientific article

Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes.

scientific article published on 18 November 2016

Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.).

scientific article published on September 2001

Polyhydroxylated pyrrolidine and pyrrolizidine alkaloids from Hyancinthoides non-scripta and Scilla campanulata

scientific article published on 01 March 1999

Protective effects of dietary 1,5-anhydro-D-glucitol as a blood glucose regulator in diabetes and metabolic syndrome

scientific article published on 11 January 2013

Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.

scientific article published on 26 June 2012

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain ⬇️

scientific article published on April 21, 2011

Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics

scientific article

Skeletal rearrangement of seven-membered iminosugars: synthesis of (-)-adenophorine, (-)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors

scientific article published on 2 April 2013

Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol

scientific article

Specific alpha-galactosidase inhibitors, N-methylcalystegines--structure/activity relationships of calystegines from Lycium chinense ⬇️

scientific article published on 01 September 1997

Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine

scientific article published on 01 October 2015

Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity

scientific article published on 19 June 2020

Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas

scientific article published on 15 October 2016

Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids.

scientific article published on 13 October 2016

Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase

scientific article published on 22 May 2008

Synthesis and biological evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-l-fucosidases.

scientific article published on 24 August 2013

Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors

scientific article published on 11 June 2014

Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for α-glucosidase recognition.

scientific article published on 30 November 2016

Synthesis and glycosidase inhibition of N-substituted derivatives of 1,4-dideoxy-1,4-imino-d-mannitol (DIM)

scientific article published on 16 January 2020

Synthesis and glycosidase inhibition of australine and its fluorinated derivatives.

scientific article

Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C-allyl iminosugar

scientific article published on 18 July 2019

Synthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloid

scientific article published in June 2010

Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol

scientific article published on 27 July 2012

Synthesis of 1,2-cis-homoiminosugars derived from GlcNAc and GalNAc exploiting a β-amino alcohol skeletal rearrangement.

scientific article published on 20 October 2014

Synthesis of 1,2-trans-2-acetamido-2-deoxyhomoiminosugars

scientific article published on 20 October 2014

Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit ofSimplified Structures and Potent β-N-Acetylhexosaminidase Inhibition

scientific article published on 25 March 2020

Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors

scientific article

Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of β-N-acetylhexosaminidases

scientific article

Synthesis of fully substituted polyhydroxylated pyrrolizidines via Cope-House cyclization

scientific article published on 28 July 2011

Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer

scientific article published on 16 April 2016

Synthesis of pyrrolidine-based analogues of 2-acetamidosugars as N-acetyl-D-glucosaminidase inhibitors

scientific article published on 10 March 2015

Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols

scientific article published on 01 June 2014

Synthesis of the naringinase inhibitors l-swainsonine and related 6-C-methyl-l-swainsonine analogues: (6R)-C-methyl-l-swainsonine is a more potent inhibitor of l-rhamnosidase by an order of magnitude than l-swainsonine

article

Synthesis of uronic-noeurostegine--a potent bacterial β-glucuronidase inhibitor.

scientific article

Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether-Bridged Iminosugars

article

Synthetic Chemical Inducers and Genetic Decoupling Enable Orthogonal Control of the rhaBAD Promoter.

scientific article published on 31 May 2016

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

scientific article

The effects of calystegines isolated from edible fruits and vegetables on mammalian liver glycosidases

scientific article published on 01 December 1997

The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-D-ribitol, on eukaryotic DNA polymerases

scientific article published in April 2003

The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors

scientific article published on 30 November 2010

ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity.

scientific article

Total Synthesis of Natural Hyacinthacine C5 and Six Related Hyacinthacine C5 Epimers.

scientific article

Total synthesis and glycosidase inhibition of broussonetine I and J(2)

scientific article published on 29 July 2013

Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes

scientific article published in October 2010

Tuning of β-glucosidase and α-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules

scientific article published on 27 June 2017

Two subsites on the active center of pig kidney trehalase.

scientific article

α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia

scientific article

γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

scientific article published on 01 March 2015

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