List of works - Simone M Schoenwaelder

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

scientific article published on 27 September 2016

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

scientific article

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

scientific article published on 01 January 2012

A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

scientific article

Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

scientific article published on 01 October 1994

Antiplatelet therapy: in search of the 'magic bullet'.

scientific article published on October 2003

Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!

scientific article

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

scientific article

Bcl-xL–inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function ⬇️

scientific article published on 01 February 2012

Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots

scientific article published on 01 January 1997

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

scientific article

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets

scientific article published on 14 March 2018

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 30 August 2017

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

scientific article

Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets

scientific article published on 01 October 1997

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice

scientific article

Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

scientific article

Endogenous fibrinolysis facilitates clot retraction in vivo

scientific article

Ferric chloride thrombosis model: unraveling the vascular effects of a highly corrosive oxidant

scientific article published on 26 October 2015

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

scientific article published in February 2010

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

scientific article

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

scientific article published on 02 August 2007

Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2

scientific article (publication date: 12 September 2003)

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

scientific article published on 21 May 2018

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

scientific article published in February 2013

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

scientific article

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

scientific article

New insights into the haemostatic function of platelets.

scientific article

Non-receptor protein tyrosine kinases and phosphatases in human platelets

scientific article published on 01 November 1996

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

scientific article published on 8 October 2009

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

scientific article published on August 2007

Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells

scientific article published on 16 June 2008

PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3.

scientific article published on January 2010

PI 3-kinase p110beta: a new target for antithrombotic therapy

scientific journal article

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

scientific article

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

scientific article

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.

scientific article

Procoagulant platelets: are they necrotic?

scientific article published on 10 June 2010

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

scientific article

Rap1b is required for normal platelet function and hemostasis in mice

scientific article

Rap1b is required for normal platelet function and hemostasis in mice.

scientific article published in August 2005

RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.

scientific article published on 5 February 2002

Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways

scientific article published in July 2010

Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation

scientific article published in March 2008

Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.

scientific article

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi ⬇️

scientific article published on April 2, 2013

The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.

scientific article published on October 1996

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

scientific article published on 5 November 2010

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

scientific article

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency

scientific article published on 03 January 2006

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

scientific article

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms

scientific article published on 14 January 2019

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 22 April 2009

Type I phosphoinositide 3-kinases: potential antithrombotic targets?

scientific article

Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers

scientific article published on 01 December 1994

List of works by Simone M Schoenwaelder

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

Antiplatelet therapy: in search of the 'magic bullet'.

Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Bcl-xL–inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function ⬇️

Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice

Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

Endogenous fibrinolysis facilitates clot retraction in vivo

Ferric chloride thrombosis model: unraveling the vascular effects of a highly corrosive oxidant

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

New insights into the haemostatic function of platelets.

Non-receptor protein tyrosine kinases and phosphatases in human platelets

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells

PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3.

PI 3-kinase p110beta: a new target for antithrombotic therapy

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.

Procoagulant platelets: are they necrotic?

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Rap1b is required for normal platelet function and hemostasis in mice

Rap1b is required for normal platelet function and hemostasis in mice.

RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.

Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways

Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation

Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi ⬇️

The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

Type I phosphoinositide 3-kinases: potential antithrombotic targets?

Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers