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List of works by Karen Lillycrop

ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity

scientific article published on 26 April 2017

Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH.

scientific article published on 31 March 2016

An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth

scientific article

Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour.

scientific article published on 22 April 2015

Associations between DNA methylation of a glucocorticoid receptor promoter and acute stress responses in a large healthy adult population are largely explained by lifestyle and educational differences

scientific article published on 05 October 2011

Breast cancer and the importance of early life nutrition

scientific article published on January 2014

Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism

scientific article published on 01 December 2018

Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight

scientific article published on 12 January 2021

Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth

scientific article

Correction of unexpected distributions of P values from analysis of whole genome arrays by rectifying violation of statistical assumptions ⬇️

scientific article published on March 11, 2013

DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years

scientific article published on 02 September 2016

DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood

scientific article published on 31 August 2017

DNA methylation of amino acid transporter genes in the human placenta.

scientific article published on 31 October 2017

DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study

scientific article published on 09 January 2022

DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake

scientific article published on 28 April 2021

Development, Epigenetics and Metabolic Programming

scientific article published on 18 April 2016

Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms

scientific article published on 08 January 2011

Dietary protein restriction during F0 pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspring

scientific article

Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations

scientific article

Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood

scientific article published on 8 January 2019

Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep

scientific article

Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3.

scientific article published on 29 November 2007

Docosahexaenoic acid and oleic acid induce altered DNA methylation of individual CpG loci in Jurkat T cells

scientific article published on 21 May 2020

Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart

scientific article

Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes

scientific article

Environment-physiology, diet quality and energy balance: the influence of early life nutrition on future energy balance

scientific article published on 04 January 2014

Environmental challenge, epigenetic plasticity and the induction of altered phenotypes in mammals

scientific article published on January 2014

Epigenetic Age Acceleration in Adolescence Associates With BMI, Inflammation, and Risk Score for Middle Age Cardiovascular Disease

scientific article published on 01 July 2019

Epigenetic gene promoter methylation at birth is associated with child's later adiposity

scientific article published on 6 April 2011

Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?

scientific article

Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS)

scientific article published on 04 December 2021

Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content

scientific article published on 8 December 2011

FUT2 Genetic Variants and Reported Respiratory and Gastrointestinal Illnesses During Infancy

scholarly article by Sheila J Barton et al published 30 October 2018 in Journal of Infectious Diseases

Fat and carbohydrate intake over three generations modify growth, metabolism and cardiovascular phenotype in female mice in an age-related manner

scientific article published on 12 August 2015

Fatty acids and epigenetics

scientific article published on March 2014

Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring

scientific article

Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring

scientific article

Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study

scientific article published on 26 April 2016

Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition

scientific article published in April 2009

Folic acid supplementation in vitro induces cell type-specific changes in BRCA1 and BRCA 2 mRNA expression, but does not alter DNA methylation of their promoters or DNA repair

scientific article published on 18 April 2015

Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood

scientific article published on November 2015

Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: Results from the MAVIDOS trial

scientific article published on 15 October 2018

Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats

scientific article

Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylatio

scientific article

Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years

scientific article published on 19 July 2021

Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells.

scientific article published on August 2004

Maternal diet alters expression of specific PPARα transcripts in the hearts of their female offspring

Maternal diet as a modifier of offspring epigenetics

scientific article published on April 2015

Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial

scientific article published on 05 November 2020

Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver

scientific article published on 27 October 2012

Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats

scientific article published on 09 March 2010

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.

scholarly article

Nerve growth factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion

scientific article

Non-imprinted epigenetics in fetal and postnatal development and growth

scientific article published on 22 January 2013

Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?

scientific article published on 12 December 2008

Nutrition, Epigenetics and Health

article

Nutritional modulation of the epigenome and its implication for future health

scientific article published on 19 February 2019

PGC1α promoter methylation in blood at 5-7 years predicts adiposity from 9 to 14 years (EarlyBird 50).

scientific article published on 12 March 2014

Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey.

scientific article

Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells

scientific article published on 5 March 2018

Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells

scientific article published on 20 August 2015

Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans

scientific article published on 12 April 2019

Prenatal famine exposure, health in later life and promoter methylation of four candidate genes.

scientific article published on December 2012

Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition

scientific article

Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses

scientific article published on 18 July 2013

Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats

scientific article

Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells

scientific article

The developmental environment, epigenetic biomarkers and long-term health.

scientific article published on 28 May 2015

The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases

scientific article published on January 2011

The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc

scientific article published on 2 July 2002

The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation

scientific article published on 11 May 2021

The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption

scientific article published on 29 August 2007

Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin

scientific article

Transcriptome-wide analysis suggests that temporal changes in the relative contributions of hyperplasia, hypertrophy and apoptosis underlie liver growth in pregnant mice

scientific article

Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial

scientific article published on 10 August 2015

Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis

scientific article

Vitamin B12 supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits.

scientific article published on 14 November 2017

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