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List of works by Joost DeJongh

A human physiologically-based model for glycyrrhzic acid, a compound subject to presystemic metabolism and enterohepatic cycling

scientific article published in December 2000

A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus

scientific article published on 22 March 2006

A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar

scientific article published on 20 November 2013

A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid

scientific article

A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans

scientific article published in January 1997

Absence of interactions on hepatic retention and 7-ethoxyresorufin-O-deethylation activity after co-administration of 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 2,4,5,2',4',5'-hexachlorobiphenyl

scientific article published on 01 October 1992

Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes

scientific article published on 3 December 2007

An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project.

scientific article

Biotransformation rates of Ugilec 141 (tetrachlorobenzyltoluenes) in rat and trout microsomes

scientific article published on 01 May 2000

Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients.

scientific article published in February 2004

Disease severity is a major determinant for the pharmacodynamics of propofol in critically ill patients

scientific article

Disease system analysis: basic disease progression models in degenerative disease

scientific article published on 22 July 2005

Disposition and elimination of three polychlorinated dibenzofurans in the liver of the rat

scientific article published on 01 May 1989

Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations.

scientific article

Evaluation of In Vitro-based simulations of toluene uptake and metabolism in rats

scientific article published on 01 October 1997

Evaluation of the impact of UGT polymorphism on the pharmacokinetics and pharmacodynamics of the novel PPAR agonist sipoglitazar

scientific article published on 24 January 2013

Evaluation of the long-term durability and glycemic control of fasting plasma glucose and glycosylated hemoglobin for pioglitazone in Japanese patients with type 2 diabetes.

scientific article

Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation.

scientific article

Induction of cytochrome P450 isoenzymes after toxicokinetic interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2',4,4',5,5'-hexachlorobiphenyl in the liver of the mouse

scientific article published on 01 May 1995

Influence of body composition on disposition of the highly fat distributed compound as analysed by physiologically based pharmacokinetic (PBPK) modeling and simulation.

scientific article published on 25 September 2017

Morphine glucuronidation in preterm neonates, infants and children younger than 3 years

scientific article

Neurite degeneration in differentiated human neuroblastoma cells

scientific article published in October 1998

Pharmacokinetic-Pharmacodynamic Modeling of Alpha Interferon Response Induced by a Toll-Like 7 Receptor Agonist in Mice

scientific article

Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain

scientific article published on 5 May 2010

Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain

scientific article published in May 2005

Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery.

scientific article published in December 2006

Pharmacokinetics of clindamycin in pregnant women in the peripartum period.

scientific article

Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks.

scientific article

Pharmacokinetics of recombinant human antithrombin in delivery and surgery patients with hereditary antithrombin deficiency.

scientific article published on 11 December 2013

Physiologically based pharmacokinetic model for tetrachlorobenzyltoluenes in rat: comparison of in vitro and in vivo metabolic rates.

scientific article

Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling

scientific article published in February 2000

Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients

scientific article published on 20 January 2006

Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%.

scientific article

Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists

scientific article

Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat.

scientific article

Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration

scientific article

Predictive Performance of a Recently Developed Population Pharmacokinetic Model for Morphine and its Metabolites in New Datasets of (Preterm) Neonates, Infants and Children

scientific article published in January 2011

Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery.

scientific article published in March 2006

Role of kinetics in acute lethality of nonreactive volatile organic compounds (VOCs).

scientific article published in September 1998

Simulation of lindane kinetics in rats.

scientific article published in September 1997

Simulation of toluene kinetics in the rat by a physiologically based pharmacokinetic model with application of biotransformation parameters derived independently in vitro and in vivo.

scientific article published in August 1996

The effects of 2,2',4,4',5,5'-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice

scientific article published on 01 October 1995

The metabolism of 2,3,7,8-tetrabromodibenzodioxin in the rat

scientific article published on 01 January 1993

The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity.

scientific article published on January 1994

Toxicokinetic interactions between chlorinated aromatic hydrocarbons in the liver of the C57BL/6J mouse: I. Polychlorinated biphenyls (PCBs)

scientific article published on 01 January 1993

Toxicokinetic mixture interactions between chlorinated aromatic hydrocarbons in the liver of the C57BL/6J mouse: 2. Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs)

scientific article published on 01 January 1993

Toxicokinetics of an environmentally relevant mixture of dioxin-like PHAHs with or without a non-dioxin-like PCB in a semi-chronic exposure study in female Sprague Dawley rats

scientific article published on 01 October 1998

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