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List of works by Eric S. Fischer

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.

scientific article published on 7 November 2017

Acute pharmacological degradation of Helios destabilizes regulatory T cells

scientific article published on 25 May 2021

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).

scientific article published on 16 April 2018

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

scientific article published on 14 March 2024

Crystal structure of the human COP9 signalosome

scientific article

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome

scientific article

Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!

scientific article published on 06 May 2011

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

scientific article published on 19 December 2017

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

scientific article published on 15 October 2021

Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein

scientific article

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity

scientific article published on 24 July 2018

MEN1 mutations mediate clinical resistance to menin inhibition

scientific article published on 15 March 2023

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

scientific article

Plasticity in binding confers selectivity in ligand-induced protein degradation

scientific article published on 11 June 2018

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

scientific article published on 27 July 2017

Rapid 'mix and read' assay for scalable detection of SARS-CoV-2 antibodies in patient plasma

scientific article published on 03 September 2020

SPLINTS: small-molecule protein ligand interface stabilizers

scientific article published on 29 January 2016

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

scientific article published on 01 August 2019

Small-molecule-induced polymerization triggers degradation of BCL6

scientific article published on 18 November 2020

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase

scientific article

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

scientific article published on 04 November 2019

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

scientific article

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases

scientific article published on 09 February 2023

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

scientific article published on 25 March 2019

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

scientific article published on 15 June 2020

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

scientific article published on 01 August 2018

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

scientific article published on 03 June 2020

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

scientific article

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

scientific article published on 27 April 2020

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

scientific article published on 22 May 2017

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