List of works - Brandon W. Higgs

A Blood-based Assay for Assessment of Tumor Mutational Burden in First-line Metastatic NSCLC Treatment: Results from the MYSTIC Study

scientific article published on 22 December 2020

A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth ⬇️

scientific article published on August 22, 2011

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients ⬇️

scientific article published on February 23, 2013

A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young children.

scientific article published on 12 February 2010

Allospecific CD154+ B cells associate with intestine allograft rejection in children

scientific article published on December 2010

Allospecific CD154+ T cells identify rejection-prone recipients after pediatric small-bowel transplantation.

scientific article published on 26 June 2009

Allospecific CD154+ T-cytotoxic memory cells identify recipients experiencing acute cellular rejection after renal transplantation

scientific article published in August 2011

Allospecific CD154 + T-cytotoxic memory cells as potential surrogate for rejection risk in pediatric intestine transplantation

scientific article published on 29 November 2011

Altered expression of insulin receptor isoforms in breast cancer

scientific article (publication date: 2011)

Baseline Plasma Cell Gene Signature Predicts Improvement in Systemic Sclerosis Skin Scores Following Treatment With Inebilizumab (MEDI-551) and Correlates With Disease Activity in Systemic Lupus Erythematosus and Chronic Obstructive Pulmonary Diseas

scientific article published on 22 October 2018

Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis.

scientific article

BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data.

scientific article

CD4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate COPD Phenotypes.

scientific article published on 23 August 2015

CallSim: Evaluation of Base Calls Using Sequencing Simulation

scientific article

Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab

scientific article published on 09 August 2018

Early detection of tuberculosis outbreaks among the San Francisco homeless: trade-offs between spatial resolution and temporal scale

scientific article (publication date: 12 December 2007)

Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects

scientific article published on 16 September 2009

Elevated myeloid: plasmacytoid dendritic cell ratio associates with early acute cellular rejection in pediatric small bowel transplantation

scientific article published in January 2010

Enhanced B Cell Alloantigen Presentation and Its Epigenetic Dysregulation in Liver Transplant Rejection

scientific article published on 11 December 2015

Expression profiles of mitochondrial genes in the frontal cortex and the caudate nucleus of developing humans and mice selectively bred for high and low fear

scientific article

Gene expression and genetic variation data implicate PCLO in bipolar disorder

scientific article

Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection.

scientific article

Genome-wide association studies in biliary atresia

scientific article published on 11 May 2015

Genomic signatures characterize leukocyte infiltration in myositis muscles.

scientific article

Genomic signatures of strain selection and enhancement in Bacillus atrophaeus var. globigii, a historical biowarfare simulant

scientific article published in 2011

Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression

scientific article

HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma

scientific article

High-throughput RNA sequencing reveals distinct gene signatures in active IgG4-related disease

scientific article published on 14 December 2017

Identification of activated cytokine pathways in the blood of systemic lupus erythematosus, myositis, rheumatoid arthritis, and scleroderma patients

scientific article published on 31 August 2011

Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus

scientific article

In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage.

scientific article published on 10 November 2015

Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

scientific article

Increased expression of peripheral blood leukocyte genes implicate CD14+ tissue macrophages in cellular intestine allograft rejection.

scientific article

Inhibition of myogenic microRNAs 1, 133, and 206 by inflammatory cytokines links inflammation and muscle degeneration in adult inflammatory myopathies.

scientific article published on April 2014

Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab

scientific article published on 01 May 2018

Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases

scientific article

Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy

scientific article

Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma.

scientific article published on 02 December 2016

Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients.

scientific article published on September 2013

Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations

scientific article

Meta-analysis of 12 genomic studies in bipolar disorder

scientific article published on 01 January 2007

MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.

scientific article published on 17 January 2014

Molecular profiling to diagnose a case of atypical dermatomyositis.

scientific article published on 3 June 2013

Mucosal plasma cell barrier disruption during intestine transplant rejection.

scientific article published on December 2012

NOD2 gene polymorphism rs2066844 associates with need for combined liver-intestine transplantation in children with short-gut syndrome

scientific article published on 19 October 2010

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

scientific article published on 28 July 2011

Pharmacogenomics and translational simulations to bridge indications for an anti-interferon-α receptor antibody

scientific article published on 14 February 2013

PheMaDB: a solution for storage, retrieval, and analysis of high throughput phenotype data

scientific article

Population Modeling of Tumor Kinetics and Overall Survival to Identify Prognostic and Predictive Biomarkers of Efficacy for Durvalumab in Patients with Urothelial Carcinoma.

scientific article published on 15 December 2017

Profile of the Pleximmune blood test for transplant rejection risk prediction

scientific article published on 13 January 2016

Proliferative alloresponse of T cytotoxic cells identifies rejection-prone children with small bowel transplantation

scientific article published in June 2010

Proliferative alloresponse of T-cytotoxic cells identifies rejection-prone children with steroid-free liver transplantation.

scientific article

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

scientific article published on 6 December 2016

Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis

scientific article published on 01 September 2011

Spectral embedding finds meaningful (relevant) structure in image and microarray data

scientific article

Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis

scientific article published on 20 May 2015

Suppression of soluble T cell-associated proteins by an anti-interferon-α monoclonal antibody in adult patients with dermatomyositis or polymyositis.

scientific article published on 19 December 2013

Synergistic immunosuppression and unintended consequences

scientific article

The Role of ARF6 in Biliary Atresia.

scientific article published on 17 September 2015

The plasma cell signature in autoimmune disease

scientific article published on 01 January 2014

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

scientific article published on 18 February 2019

The transcription factor, T-bet, primes intestine transplantation rejection and is associated with disrupted mucosal homeostasis.

scientific article published in April 2015

Type I interferon: potential therapeutic target for psoriasis?

scientific article

Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus.

scientific article published on 14 April 2010

List of works by Brandon W. Higgs

A Blood-based Assay for Assessment of Tumor Mutational Burden in First-line Metastatic NSCLC Treatment: Results from the MYSTIC Study

A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth ⬇️

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients ⬇️

A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young children.

Allospecific CD154+ B cells associate with intestine allograft rejection in children

Allospecific CD154+ T cells identify rejection-prone recipients after pediatric small-bowel transplantation.

Allospecific CD154+ T-cytotoxic memory cells identify recipients experiencing acute cellular rejection after renal transplantation

Allospecific CD154 + T-cytotoxic memory cells as potential surrogate for rejection risk in pediatric intestine transplantation

Altered expression of insulin receptor isoforms in breast cancer

Baseline Plasma Cell Gene Signature Predicts Improvement in Systemic Sclerosis Skin Scores Following Treatment With Inebilizumab (MEDI-551) and Correlates With Disease Activity in Systemic Lupus Erythematosus and Chronic Obstructive Pulmonary Diseas

Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis.

BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data.

CD4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate COPD Phenotypes.

CallSim: Evaluation of Base Calls Using Sequencing Simulation

Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab

Early detection of tuberculosis outbreaks among the San Francisco homeless: trade-offs between spatial resolution and temporal scale

Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects

Elevated myeloid: plasmacytoid dendritic cell ratio associates with early acute cellular rejection in pediatric small bowel transplantation

Enhanced B Cell Alloantigen Presentation and Its Epigenetic Dysregulation in Liver Transplant Rejection

Expression profiles of mitochondrial genes in the frontal cortex and the caudate nucleus of developing humans and mice selectively bred for high and low fear

Gene expression and genetic variation data implicate PCLO in bipolar disorder

Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection.

Genome-wide association studies in biliary atresia

Genomic signatures characterize leukocyte infiltration in myositis muscles.

Genomic signatures of strain selection and enhancement in Bacillus atrophaeus var. globigii, a historical biowarfare simulant

Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression

HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma

High-throughput RNA sequencing reveals distinct gene signatures in active IgG4-related disease

Identification of activated cytokine pathways in the blood of systemic lupus erythematosus, myositis, rheumatoid arthritis, and scleroderma patients

Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus

In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage.

Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

Increased expression of peripheral blood leukocyte genes implicate CD14+ tissue macrophages in cellular intestine allograft rejection.

Inhibition of myogenic microRNAs 1, 133, and 206 by inflammatory cytokines links inflammation and muscle degeneration in adult inflammatory myopathies.

Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab

Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases

Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy

Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma.

Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients.

Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations

Meta-analysis of 12 genomic studies in bipolar disorder

MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.

Molecular profiling to diagnose a case of atypical dermatomyositis.

Mucosal plasma cell barrier disruption during intestine transplant rejection.

NOD2 gene polymorphism rs2066844 associates with need for combined liver-intestine transplantation in children with short-gut syndrome

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

Pharmacogenomics and translational simulations to bridge indications for an anti-interferon-α receptor antibody

PheMaDB: a solution for storage, retrieval, and analysis of high throughput phenotype data

Population Modeling of Tumor Kinetics and Overall Survival to Identify Prognostic and Predictive Biomarkers of Efficacy for Durvalumab in Patients with Urothelial Carcinoma.

Profile of the Pleximmune blood test for transplant rejection risk prediction

Proliferative alloresponse of T cytotoxic cells identifies rejection-prone children with small bowel transplantation

Proliferative alloresponse of T-cytotoxic cells identifies rejection-prone children with steroid-free liver transplantation.

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis

Spectral embedding finds meaningful (relevant) structure in image and microarray data

Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis

Suppression of soluble T cell-associated proteins by an anti-interferon-α monoclonal antibody in adult patients with dermatomyositis or polymyositis.

Synergistic immunosuppression and unintended consequences

The Role of ARF6 in Biliary Atresia.

The plasma cell signature in autoimmune disease

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

The transcription factor, T-bet, primes intestine transplantation rejection and is associated with disrupted mucosal homeostasis.

Type I interferon: potential therapeutic target for psoriasis?

Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus.