List of works by Neil B Ruderman

14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.

scientific article published on March 2002

A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia.

scientific article published on June 1971

A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation

scientific article published on 01 August 1995

A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells

scientific article

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli

scientific article published in April 2004

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

scientific article published in October 2002

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

scientific article

AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms

scientific article published on August 2004

AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats

scientific article published on 14 June 2005

AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance

scientific article published on 5 April 2008

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

scientific article published on 14 September 2004

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise

scientific article

AMPK and SIRT1: a long-standing partnership?

scientific article

AMPK and the biochemistry of exercise: implications for human health and disease

scientific article published on March 2009

AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.

scientific article

AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells.

scientific article published in November 2004

AMPK regulation of the growth of cultured human keratinocytes

scientific article published on 28 August 2006

AMPK, insulin resistance, and the metabolic syndrome

scientific article published on July 2013

AMPK, the metabolic syndrome and cancer

scientific article

Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones

scientific article

Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes

scientific article published on 01 December 1987

Acetoacetate as a fuel for perfused rat skeletal muscle ⬇️

scientific article published on January 1, 1971

Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization

scientific article published on 5 June 2009

Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes

scientific article

Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio

scientific journal article

Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

scientific article published in Journal of Biological Chemistry

Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes

scientific article

Acute exercise activates AMPK and eNOS in the mouse aorta

scientific article

Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells

scientific article published in June 2001

Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis

scientific article published on 01 October 1981

Additive effects of prior exercise and insulin on glucose and AIB uptake by rat muscle

scientific article published on 01 July 1986

Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion

scientific article published on 22 April 2009

Alanine metabolism and gluconeogenesis in the rat.

scientific article published in August 1976

Alpha and Beta adrenergic effects on metabolism in contracting, perfused muscle

scientific article published on 01 November 1982

Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles

scientific article published on 01 October 1992

Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle

scientific article published in August 2002

Amino acid metabolism in skeletal muscle. Regulation of glutamine and alanine release in the perfused rat hindquarter.

scientific article

An electron microscopic study of lipoprotein production and release by the isolated perfused rat liver

scientific article published on 01 October 1966

Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy

scientific article published on 06 July 2009

Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study

scientific article

Brain metabolism in diabetes

scientific article published on 01 January 1980

CELL BIOLOGY: Enhanced: Chewing the Fat--ACC and Energy Balance

scientific article published in Science

Cardiorespiratory fitness attenuates mortality associated with the metabolic syndrome

scientific article published in July 2005

Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium

scientific article published on 01 October 1988

Chronic hypoglycemia increases brain glucose transport

scientific article

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

scientific article

Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise

scientific journal article

Could intranasal insulin be useful in the treatment of non-insulin-dependent diabetes mellitus?

scientific article published in August 1991

Cutting the Gordian knot. Addition of metformin to insulin therapy in a patient with uncontrolled diabetes and schizophrenia

article

Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo

scientific article published on 01 June 1999

Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

scientific article

Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity

scientific article

Diabetes as an atherogenic factor.

scientific article published on March 1984

Diabetes, exercise, and atherosclerosis

scientific article published on November 1, 1992

Diabetes-induced alterations of glucose metabolism in rat cerebral microvessels

scientific article published in October 1984

Diacylglycerol-protein kinase C signalling in skeletal muscle: a possible link to insulin resistance.

scientific article published in January 1991

Dichloroacetate: Effects on exercise endurance in untrained rats

scientific article published on 01 June 1981

Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA.

scientific article published in December 1997

Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats

scientific article published in January 2005

Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels

scientific article published on 01 November 1993

Differential stimulation of Na+ pump activity by insulin and nitric oxide in rabbit aorta

scientific article published on 01 April 1996

Dissociation of 5' AMP-activated protein kinase activation and glucose uptake stimulation by mitochondrial uncoupling and hyperosmolar stress: differential sensitivities to intracellular Ca2+ and protein kinase C inhibition

scientific article published in July 2001

Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle

scientific article published on 3 August 2010

Effect of acute insulin deprivation on rat liver glucokinase

scientific article published on 01 October 1968

Effect of diabetes on the induction of ornithine decarboxylase by refeeding

scientific article published in August 1979

Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle

scientific article published on 01 January 1989

Effect of insulin on protein synthesis and degradation in skeletal muscle after exercise

scientific article published on 01 January 1990

Effect of oleate concentration on its metabolism by the perfused rat liver

scientific article published on 01 May 1968

Effect of prior exercise and insulin on potential thermogenic systems in rat skeletal muscle

scientific article published on 01 June 1992

Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter

scientific article published on 01 February 1977

Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels

scientific article published in March 1988

Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver

scientific article published on 01 September 1967

Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta

scientific article published on 01 July 1991

Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide ⬇️

scientific article published on September 1, 1992

Energy state of bovine cerebral microvessels: comparison of isolation methods

scientific article

Enhanced Stimulation of Diacylglycerol and Lipid Synthesis by Insulin in Denervated Muscle: Altered Protein Kinase C Activity and Possible Link to Insulin Resistance ⬇️

scientific article published on December 1, 1991

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

scientific article

Enhanced muscle glucose metabolism after exercise in the rat: the two phases

scientific article published on 01 June 1984

Enzymes of carbohydrate and fat metabolism in anti-insulin serum diabetes; inactivation by free fatty acids and the protective effect of cellular protein.

scientific article published in December 1974

Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism ⬇️

scientific article published on September 1, 1971

Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle.

scientific article published on February 1986

Exercise and insulin signaling: a historical perspective

scientific article

Exercise and physical training in the treatment of diabetes mellitus

scientific article published on 01 January 1986

Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle

scientific article published on 01 August 2000

Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle

scientific article

Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

scientific article published in July 2000

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver

scientific article published in December 2005

Glucogenic substrate levels in fasting man.

scientific article published in January 1975

Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate

scientific article

Glucose and diabetic vascular disease.

scientific article

Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase

scientific article

Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels

scientific article published in March 1990

Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition ⬇️

scientific article published on August 15, 1976

Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake ⬇️

scientific article published on January 1, 1975

Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies and free fatty acids.

scientific article

Glucose regulation of hepatic gluconeogenesis.

scientific article published in June 1968

Glucose represses PPARα gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell

scientific article published on 8 July 2009

Glucose uptake and insulin sensitivity in rat muscle: changes during 3-96 weeks of age

scientific article published on 01 January 1983

Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise.

scientific article published in December 1986

H.D.L. IN DIABETES

scientific article published in The Lancet

Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity

scientific article

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

scientific article

Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation

scientific article published in January 2002

Impaired fibrinolytic response to exercise in type II diabetes: Effects of exercise and physical training

article

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats

scientific article published on 18 October 2005

Influence of muscle use on amino acid metabolism.

scientific article published on January 1982

Inhibition of hepatic gluconeogenesis and fatty acid oxidation by pent-4-enoic acid.

scientific article published in July 1970

Inhibition of hepatic gluconeogenesis by 4-pentenoic acid.

scientific article published in March 1970

Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle

scientific journal article

Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis.

scientific article published in January 1974

Insulin and exercise stimulate muscle alpha-aminoisobutyric acid transport by a Na+-K+-ATPase independent pathway

scientific article published in February 1986

Insulin binding and sensitivity in rat skeletal muscle: effect of starvation

scientific article published on 01 February 1981

Insulin increases a biochemically distinct pool of diacylglycerol in the rat soleus muscle

scientific article published on 01 March 1994

Insulin increases thermogenesis in rat skeletal muscle following exercise

scientific article published on 01 January 1985

Insulin preservation of glucokinase activity in isolated perfused rat liver

scientific article published on 01 May 1967

Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?

scientific article published on October 2011

Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation

scientific article

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue

scientific article published on 8 February 2012

Insulin sensitivity of rat skeletal muscle: effects of starvation and aging

scientific article published on May 1, 1979

Insulin-enhanced thermogenesis in skeletal muscle after exercise: regulatory factors

scientific article published on 01 September 1986

Insulin-like growth factor I binding and receptor kinase in red and white muscle

scientific article published on 01 July 1988

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle

scientific article published on 01 February 1993

Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes.

scientific article published in April 1985

Intrinsic differences of insulin receptor kinase activity in red and white muscle

scientific article published on 01 November 1986

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.

scientific article

Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol

scientific article published on 01 July 1994

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

scientific article published in July 2002

MYOPATHIC DISORDER ASSOCIATED WITH MITOCHONDRIAL ABNORMALITIES, HYPERGLYCÆMIA, AND HYPERKETONÆMIA

scientific article published in The Lancet

Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity

scientific article published on 01 January 1998

Malonyl coenzyme A and adiposity in the dahl salt-sensitive rat: Effects of pioglitazone

scientific article published on 01 April 1996

Malonyl-CoA and AMP-activated protein kinase: an expanding partnership

scientific article published on November 1, 2003

Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise

scientific article published on 21 September 2004

Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo.

scientific article published in August 2000

Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle

scientific article published on 01 April 1997

Metabolic and hormonal interactions between muscle and adipose tissue

scientific article published in May 2004

Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrations

scientific article published on 01 May 1988

Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.

scientific article

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists

scientific article

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

scientific article published on 18 September 2003

Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion

scientific article published on 25 July 2011

Muscle Amino Acid Metabolism and Gluconeogenesis ⬇️

scientific article published on January 1, 1975

Muscle alpha-aminoisobutyric acid transport after exercise: enhanced stimulation by insulin

scientific article published on 01 May 1985

Muscle glucose oxidation.

scientific article published in October 1985

Muscle glycogenolysis during exercise: dual control by epinephrine and contractions

scientific article published on 01 January 1982

Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat

scientific article published on 01 December 1999

Muscle nitrogen metabolism in chronic hepatic insufficiency

scientific article published on 01 April 1976

Non-beta-cell tumor hypoglycemia associated with increased nonsuppressible insulin-like protein (NSILP)

scientific article published on January 1, 1979

Obesity-associated disorders in normal-weight individuals: some speculations

scientific article published on 01 January 1982

Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes

scientific article published in October 2005

Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins

scientific article published on 10 August 2011

Ornithine decarboxylase activity in insulin-deficient states.

scientific article published on November 1980

Oxygen consumption in perfused skeletal muscle. Effect of perfusion with aged, fresh and aged-rejuvenated erythrocytes on oxygen consumption, tissue metabolites and inhibition of glucose utilization by acetoacetate.

scientific article published on July 1980

Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide.

scientific article published in June 2005

Partial characterization of an insulin-dependent serum factor that regulates ornithine decarboxylase in skeletal muscle

scientific article published on 01 June 1982

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution

scientific article published in February 1992

Physical activity/exercise and diabetes mellitus

scientific article published on 01 January 2003

Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers

scientific article

Physical training and cardiovascular disease in the diabetic

scientific article published on 01 January 1982

Pioglitazone acutely reduces energy metabolism and insulin secretion in rats

scientific article published on February 2013

Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations

scientific article

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

scientific article published on February 2004

Polymyxin B inhibits contraction-stimulated glucose uptake in rat skeletal muscle

scientific article published in April 1991

Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes

scientific article

Prior exercise potentiates the thermic effect of a carbohydrate load

scientific article published on 01 November 1986

Protein conservation during starvation: possible role of lipid fuels

scientific article published on 01 January 1982

Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus

scientific article published on 30 November 2012

Reduced Na(+)-K+ pump activity in diabetic rabbit carotid artery: reversal by aldose reductase inhibition

scientific article published on 01 October 1993

Regulation of alanine formation and release in rat muscle in vivo: effect of starvation and diabetes

scientific article published on 01 August 1977

Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR.

scientific article published in August 2001

Regulation of ketone body metabolism in skeletal muscle.

scientific article

Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus

scientific article

Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation.

scientific article published in December 1986

Regulation of ornithine decarboxylase in skeletal muscle: evidence for the involvement of an insulin-dependent serum factor

scientific article published on 01 August 1981

Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle

scientific article published on 01 November 1993

Regulation of production and release of lipoprotein by the perfused rat liver

scientific article published on 01 September 1968

Relation of fatty acid oxidation tgluconeogenesis: effect of pentenoic acid.

scientific article

Role of endothelium-derived nitric oxide in stimulation of Na(+)-K(+)-ATPase activity by endothelin in rabbit aorta

scientific article published on 01 February 1994

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

scientific article

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

scientific article

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

scientific journal article

Sites of protein conservation and loss during starvation: influence of adiposity

scientific article published in May 1984

Skeletal muscle: reservoir for exogenous L-dopa

scientific article

Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus

scientific article

Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein

scientific article published on 01 October 1980

Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism

scientific article published on 01 October 1980

Stimulation of vascular Na(+)-K(+)-ATPase activity by nitric oxide: a cGMP-independent effect

scientific article published on 01 May 1994

Studies on the mechanism of improved glucose control during regular exercise in Type 2 (non-insulin-dependent) diabetes

scientific article published on 01 May 1984

Substrate utilization in perfused skeletal muscle

scientific article published in January 1979

Synthesis of Essential Amino Acids from Their α-Keto Analogues by Perfused Rat Liver and Muscle ⬇️

scientific article published on November 1, 1973

Ten-Year Experience with an Exercise-Based Outpatient Life-Style Modification Program in the Treatment of Diabetes Mellitus

scientific article published on 01 November 1992

The "metabolically-obese," normal-weight individual.

scientific article published on August 1981

The Effect of AMP-Activated Protein Kinase and Its Activator AICAR on the Metabolism of Human Umbilical Vein Endothelial Cells

scientific article published in 1999

The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes

scientific article published in January 1979

The evolution of insulin resistance in muscle of the glucose infused rat

scientific article

The formation of glutamine and alanine in skeletal muscle.

scientific article published in September 1974

The lost symposium. Diabetes and exercise 1990

scientific article published on 01 June 1993

The metabolically obese, normal-weight individual revisited

scientific article

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin

scientific article published on 01 August 1994

The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver

scientific article published on 01 February 1970

Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues

scientific article published on 7 February 2006

Why Might Thiazolidinediones Increase Exercise Capacity in Patients With Type 2 Diabetes?

scientific article published on 01 December 2005

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