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List of works by Kevin Gaston

A cancer cell-specific inducer of apoptosis

scientific article published in June 2007

A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors

scientific article

A quadrivalent vaccine for human papillomavirus.

scientific article published on November 2006

CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation.

scientific article

CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism

Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus

scientific article

CpG methylation and the binding of YY1 and ETS proteins to the Surf-1/Surf-2 bidirectional promoter

scientific article published on 01 May 1995

DNA binding and bending by the human papillomavirus type 16 E2 protein. Recognition of an extended binding site

scientific article published on 01 March 1997

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers.

scientific article published on 31 July 2010

DNA wrapping and distortion by an oligomeric homeodomain protein

scientific article

Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes.

scientific article

Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.

scientific article published in February 2006

Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death.

scientific article published on October 2004

Human T cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells

article

Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulval intraepithelial neoplasia

scientific article published in August 2003

In situ subcellular fractionation of adherent and non-adherent mammalian cells

scientific article

Magnesium ions enhance the transfer of human papillomavirus E2 protein from non-specific to specific binding sites

scientific article published on 01 December 1999

Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion

scientific article

Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors

scientific article published on 01 June 2000

Novel mechanisms of resistance to vemurafenib in melanoma - V600E B-Raf reversion and switching VEGF-A splice isoform expression

scientific article published on 15 December 2014

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain

scientific article

P53 represses human papillomavirus type 16 DNA replication via the viral E2 protein

scientific article

PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.

scientific article published on 18 November 2013

PRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling.

scientific article

Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth

scientific article published on 12 June 2017

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.

scientific article

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.

scientific article published on 16 September 2017

Purification and characterisation of the PRH homeodomain: Removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.

scientific article published on 21 February 2006

Purification of the proline-rich homeodomain protein.

scientific article

Stringent spacing requirements for transcription activation by CRP.

scientific article

The Enigmatic Origin of Papillomavirus Protein Domains

scientific article

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors

scientific article

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

scientific article published in January 2000

The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins

scientific article

The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation

scientific article

The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein

scientific article published on 12 August 2006

Transcription from the Escherichia coli melR promoter is dependent on the cyclic AMP receptor protein

scientific article published on 01 September 1988

Transcriptional repression in eukaryotes: repressors and repression mechanisms.

scientific article

YY1 is involved in the regulation of the bi-directional promoter of the Surf-1 and Surf-2 genes

scientific article published on 01 June 1994

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