List of works - Heung-Chin Cheng

1H, 13C and 15N chemical shift assignments of the SH2 domain of the Csk homologous kinase

scientific article published on 01 December 2002

A Peptide Corresponding to Residues Asp177 to Asn208 of Human Cyclin A Forms an α-Helix

scientific article published in 1998

A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

scientific article published on 17 February 2016

A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases

scientific article published on 5 November 2010

A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity

scientific article published on 25 February 2004

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

scientific article published on 11 February 2013

Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity

scientific article published on August 2012

Activation of Src family tyrosine kinases by ferric ions

scientific article

Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530

Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: implications for disease-associated kinases

scientific article published on 29 June 2009

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations

scientific article published on October 2012

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).

scientific article published on 05 July 2012

Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.

scientific article published on December 1995

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

scientific article

C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases

scientific article

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

scientific article

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

scientific article published in Journal of Biological Chemistry

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

scientific article published on 25 September 2006

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

scientific article published in March 2011

Common in vitro substrate specificity and differential Src homology 2 domain accessibility displayed by two members of the Src family of protein-tyrosine kinases, c-Src and Hck.

scientific article published in July 1998

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

scientific article

Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression

Decreased CHK protein levels are associated with Src activation in colon cancer cells.

scientific article

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate

scientific article

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.

scientific article published on 25 July 2010

Differential in vitro phosphorylation of clathrin light chains by the epidermal growth factor receptor-associated protein tyrosine kinase and a pp60c-src-related spleen tyrosine kinase

scientific article published in February 1992

Dual role of Src kinase in governing neuronal survival

scientific article published on 31 October 2014

Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases

scientific article

Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase

scientific article

Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays

scientific article

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

scientific article published on 07 May 2019

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).

scientific article published on 19 November 2007

Modulation of the Catalytic Activity of the Src Family Tyrosine Kinase Hck by Autophosphorylation at a Novel Site in the Unique Domain

scientific article published in Journal of Biological Chemistry

PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation

scientific article

PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis

scientific article published on 20 July 2006

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).

scientific article published on 24 February 2014

Purification of Bovine Thymus Cytosolic C-Terminal Src Kinase (CSK) and Demonstration of Differential Efficiencies of Phosphorylation and Inactivation of p56lynand pp60c-srcby CSK†

scientific article published in 1996

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

scientific article published on 01 March 2019

Regulation and function of protein kinases and phosphatases

scientific article

Src family kinases and their role in hematological malignancies

scientific article

Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases

scientific article published on October 2010

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate

scientific article published on 12 October 2015

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

scientific article published on 01 November 2018

Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.

scientific article published on 27 May 2010

List of works by Heung-Chin Cheng

1H, 13C and 15N chemical shift assignments of the SH2 domain of the Csk homologous kinase

A Peptide Corresponding to Residues Asp177 to Asn208 of Human Cyclin A Forms an α-Helix

A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases

A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity

Activation of Src family tyrosine kinases by ferric ions

Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530

Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: implications for disease-associated kinases

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).

Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

Common in vitro substrate specificity and differential Src homology 2 domain accessibility displayed by two members of the Src family of protein-tyrosine kinases, c-Src and Hck.

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression

Decreased CHK protein levels are associated with Src activation in colon cancer cells.

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.

Differential in vitro phosphorylation of clathrin light chains by the epidermal growth factor receptor-associated protein tyrosine kinase and a pp60c-src-related spleen tyrosine kinase

Dual role of Src kinase in governing neuronal survival

Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases

Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase

Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).

Modulation of the Catalytic Activity of the Src Family Tyrosine Kinase Hck by Autophosphorylation at a Novel Site in the Unique Domain

PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation

PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).

Purification of Bovine Thymus Cytosolic C-Terminal Src Kinase (CSK) and Demonstration of Differential Efficiencies of Phosphorylation and Inactivation of p56lynand pp60c-srcby CSK†

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Regulation and function of protein kinases and phosphatases

Src family kinases and their role in hematological malignancies

Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.