List of works - Robert C. Reid

A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

scientific article published in May 2003

A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis

scientific article

A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease

scientific article

An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

scientific article published on 8 November 2016

An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats ⬇️

scientific article published on September 1, 2012

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.

scientific article published in September 2002

Antifibrotic Activity of an Inhibitor of Group IIA Secretory Phospholipase A2 in Young Spontaneously Hypertensive Rats

scientific article published on 01 June 2006

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

scientific article

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

scientific article published on 22 September 2010

Benzhydrylamine linker grafting: a strategy for the improved synthesis of C‐terminal peptide amides ⬇️

scientific article published on October 1, 2010

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

scientific article published on 17 December 2015

Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.

scientific article published on January 2002

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

scientific article

Chemical Approaches to Modulating Complement-Mediated Diseases.

scientific article published on 4 October 2017

Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury

scientific article

Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

scientific article

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

scientific article

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

scientific article

Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism

scientific article

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

scientific article published on 01 December 2021

Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis

scientific article published on 10 December 2015

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

scientific article published on 3 March 2010

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

scientific article

Efficient chemical synthesis of human complement protein C3a

scientific article

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor

scientific article

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

scientific article published on 24 August 2017

Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.

scientific article published on 28 December 2015

Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages

scientific article

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina

scientific article published on 9 October 2015

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro

scientific article published on 21 June 2019

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

article

Inhibition of Inflammation and Fibrosis by a Complement C5a Receptor Antagonist in DOCA-Salt Hypertensive Rats

article

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

scientific article

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

scientific article published in January 2002

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation

scientific article published on 17 August 2019

Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats

scientific article published on 9 February 2006

Inhibitors of secretory phospholipase A2 group IIA.

scientific article

Inhibitors selective for HDAC6 in enzymes and cells ⬇️

scientific article published on October 12, 2010

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

scientific article (publication date: 10 January 2017)

Nonpeptidic ligands for peptide-activated G protein-coupled receptors.

scientific article published on July 2007

Novel Agonists and Antagonists for Human Protease Activated Receptor 2 ⬇️

scientific article published on October 28, 2010

PAR2 Modulators Derived from GB88.

scientific article

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence

scientific article

Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

scientific article

Potent Small Agonists of Protease Activated Receptor 2.

scientific article published on 30 November 2015

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity

scientific article published on 07 January 2020

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

scientific article published on 23 October 2015

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

scientific article published in April 2004

Potent heterocyclic ligands for human complement c3a receptor

scientific article published on 8 October 2014

Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats

scientific article

Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine

scientific article

Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats

scientific article

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

scientific article

Selective hexapeptide agonists and antagonists for human complement C3a receptor

scientific article published in July 2010

Small Peptides Do Not Inhibit Human Non-Pancreatic Secretory Phospholipase-A2 (Type IIA)

scientific article published on 01 August 2000

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system.

scientific article published on 27 January 2015

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

scientific article published on 08 March 2017

Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides.

scientific article

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding

scientific article

The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis.

scientific article

Towards isozyme-selective HDAC inhibitors for interrogating disease.

scientific article published on January 2012

List of works by Robert C. Reid

A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis

A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease

An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats ⬇️

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.

Antifibrotic Activity of an Inhibitor of Group IIA Secretory Phospholipase A2 in Young Spontaneously Hypertensive Rats

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

Benzhydrylamine linker grafting: a strategy for the improved synthesis of C‐terminal peptide amides ⬇️

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Chemical Approaches to Modulating Complement-Mediated Diseases.

Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury

Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

Efficient chemical synthesis of human complement protein C3a

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.

Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

Inhibition of Inflammation and Fibrosis by a Complement C5a Receptor Antagonist in DOCA-Salt Hypertensive Rats

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation

Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats

Inhibitors of secretory phospholipase A2 group IIA.

Inhibitors selective for HDAC6 in enzymes and cells ⬇️

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

Nonpeptidic ligands for peptide-activated G protein-coupled receptors.

Novel Agonists and Antagonists for Human Protease Activated Receptor 2 ⬇️

PAR2 Modulators Derived from GB88.

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence

Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

Potent Small Agonists of Protease Activated Receptor 2.

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

Potent heterocyclic ligands for human complement c3a receptor

Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats

Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine

Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Selective hexapeptide agonists and antagonists for human complement C3a receptor

Small Peptides Do Not Inhibit Human Non-Pancreatic Secretory Phospholipase-A2 (Type IIA)

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system.

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides.

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding

The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis.

Towards isozyme-selective HDAC inhibitors for interrogating disease.