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List of works by Jason Roszik

4-1BB-Enhanced Expansion of CD8+ TIL from Triple-Negative Breast Cancer Unveils Mutation-Specific CD8+ T Cells

scientific article published on 4 May 2017

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

scientific article published in April 2018

A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis and Metastasis in Aneuploid Cancers

scientific article published on 04 December 2020

A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma

scientific article published on 22 August 2019

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

scientific article published on 26 September 2018

A tool for discovering drug sensitivity and gene expression associations in cancer cells

scientific article

ARID1A mutation may define an immunologically active subgroup in patients with microsatellite-stable colorectal cancer

scientific article published on 07 January 2021

AccPbFRET: an ImageJ plugin for semi-automatic, fully corrected analysis of acceptor photobleaching FRET images

scientific article

Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes

scientific article published on 18 September 2017

Analysis of MDM2 Amplification: Next-Generation Sequencing of Patients With Diverse Malignancies

scientific article published on 13 July 2018

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

scientific article published on 29 October 2020

Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma

scientific article

Beyond KRAS: Practical Molecular Targets in Pancreatic Adenocarcinoma

scientific article published on 04 January 2019

Beyond autoantibodies: Biological roles of human autoreactive B cells in rheumatoid arthritis revealed by RNA-sequencing

scientific article published on 23 February 2019

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.

scientific article

Biological Validation of RNA Sequencing Data from Formalin-Fixed Paraffin-Embedded Primary Melanomas

scientific article published on 14 June 2018

Biophysical characterization of histone H3.3 K27M point mutation

scientific article published on 21 June 2017

Cancer Genetics and Therapeutic Opportunities in Urologic Practice

scientific article published on 18 March 2020

Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.

scientific article

Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target

scientific article published in January 2017

Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target.

scientific article published on 30 August 2016

Cervical Cancer Neoantigen Landscape and Immune Activity is Associated with Human Papillomavirus Master Regulators

scientific article

Checkpoint Genes at the Cancer Side of the Immunological Synapse in Bladder Cancer

scientific article published on 20 December 2019

Clinical Next-Generation Sequencing for Precision Oncology in Rare Cancers

scientific article published on 13 April 2018

Clinical, Molecular, and Immune Analysis of Dabrafenib-Trametinib Combination Treatment for BRAF Inhibitor-Refractory Metastatic Melanoma: A Phase 2 Clinical Trial

scientific article published on 28 April 2016

Clinicopathological features and clinical outcomes associated with TP53 and BRAFNon-V600 mutations in cutaneous melanoma patients

scientific article published on 2 December 2016

Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum.

scientific article published on 18 April 2016

Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma

scientific article

Current Targeted Therapies for the Fight against Non-Small Cell Lung Cancer

scientific article published on 09 November 2020

Cylindrospermopsin induces alterations of root histology and microtubule organization in common reed (Phragmites australis) plantlets cultured in vitro.

scientific article

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer

scientific article published on 27 February 2017

Drugging the R-loop interactome: RNA-DNA hybrid binding proteins as targets for cancer therapy

scientific article published on 06 July 2019

Editorial: Targeting Metabolism in Cancer Immunotherapy

scientific article published on 11 September 2018

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

scientific article published on 01 October 2019

ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas.

scientific article

Evaluation of intensity-based ratiometric FRET in image cytometry--approaches and a software solution

scientific article

Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target

scientific article published on 17 January 2018

Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma

scientific article published on 20 October 2016

Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy

article

Genetic analysis of the 'uveal melanoma' C918 cell line reveals atypical BRAF and common KRAS mutations and single tandem repeat profile identical to the cutaneous melanoma C8161 cell line

scientific article

Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.

scientific article

Genomics, morphoproteomics, and treatment patterns of alveolar soft part sarcoma patients and response to multiple experimental therapies

scientific article published on 03 March 2020

HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

scientific article published on 6 September 2017

High-Throughput Architecture for Discovering Combination Cancer Therapeutics

scientific article published on 01 December 2018

HotSpotter: efficient visualization of driver mutations

scientific article

Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

scientific article published on 16 July 2018

Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma

scientific article published on 25 July 2016

IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation

scientific article published on 3 October 2016

Identification of predictive biomarker signatures in melanoma tumors associated with response to tumor-infiltrating lymphocyte (TIL) therapy

scientific article published on 7 November 2013

Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography

scientific article published on 31 May 2016

Imaging of T cells expressing chimeric antigen receptors

scientific article published in December 2011

Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.

scientific article

Immuno-genomic landscape of osteosarcoma

scientific article published on 21 February 2020

Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy

scientific article published on 16 March 2018

In Silico Restriction Enzyme Digests to Minimize Mapping Bias in Genomic Sequencing.

scientific article

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

scientific article published on 05 April 2018

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.

scientific article

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

scientific article

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

article

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

scientific article published on 09 September 2016

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.

scientific article published on 8 December 2015

Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature

scientific article published on 12 September 2019

MAGE-A3 is a Clinically Relevant Target in Undifferentiated Pleomorphic Sarcoma/Myxofibrosarcoma

scientific article published on 15 May 2019

Mechanisms of nuclear content loading to exosomes

scientific article published on 20 November 2019

Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology

scientific article published on 26 March 2018

Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression

scientific article published on 23 January 2016

Mining Public Databases for Precision Oncology

scientific article published on 22 May 2018

Molecular profiling of metastatic bladder cancer early-phase clinical trial participants predicts patient outcomes

scientific article published on 15 December 2020

Multifaceted role of BTLA in the control of CD8+ T cell fate after antigen encounter

scientific article

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

scientific article published on 09 May 2016

Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.

scientific article

Opportunities for Single-Cell Sequencing Technologies and Data Science

scientific article published on 19 November 2020

Outcomes of patients with sarcoma enrolled in clinical trials of pazopanib combined with histone deacetylase, mTOR, Her2, or MEK inhibitors.

scientific article

Overexpressed PRAME is a potential immunotherapy target in sarcoma subtypes

scientific article

Pan-Cancer Efficacy of Vemurafenib in BRAFV600-Mutant Non-Melanoma Cancers

scientific article published on 06 February 2020

Phase 1 Study of P-cadherin-Targeted Radioimmunotherapy with 90Y-FF-21101 Monoclonal Antibody in Solid Tumors

scientific article published on 18 August 2020

Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma

scientific article published on 4 April 2017

Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma

scientific article published on 20 June 2019

Positive Tumor Response to Combined Checkpoint Inhibitors in a Patient With Refractory Alveolar Soft Part Sarcoma: A Case Report ⬇️

scientific article published on 06 July 2017

Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4

scientific article published on 12 November 2018

Predictive immune biomarker signatures in the tumor microenvironment of melanoma metastases associated with tumor-infiltrating lymphocyte (TIL) therapy

scientific article published on 6 November 2014

Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome

RMEL3, a novel BRAFV600E-associated long noncoding RNA, is required for MAPK and PI3K signaling in melanoma.

scientific article published on 04 May 2016

RNA editing derived epitopes function as cancer antigens to elicit immune responses

scientific article published in Nature Communications

Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas

scientific article published on 17 August 2017

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition

article published in the Proceedings of the National Academy of Sciences of the United States of America

SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.

scientific article

Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells

scientific article

Somatic Copy Number Alterations at Oncogenic Loci Show Diverse Correlations with Gene Expression

scientific article published on 20 January 2016

T-cell synapse formation depends on antigen recognition but not CD3 interaction: studies with TCR:ζ, a candidate transgene for TCR gene therapy

scientific article published on 13 April 2011

TCRs genetically linked to CD28 and CD3ε do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity

scientific article published on 15 October 2014

TNFSF4 (OX40L) expression and survival in locally advanced and metastatic melanoma

scientific article published on 09 September 2019

Targeting KRAS in Cancer: Promising Therapeutic Strategies

scientific article published in 2021

Targeting iNOS to increase efficacy of immunotherapies

scientific article published on 25 January 2017

Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers

scientific article published on 24 February 2020

The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma

scientific article published on 11 December 2018

The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells

scientific article published on 03 November 2021

The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy.

scientific article published on 18 December 2017

The Expression of CD74-Regulated Inflammatory Markers in Stage IV Melanoma: Risk of CNS Metastasis and Patient Survival

scientific article published on 14 December 2020

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

scientific article

The Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non-Small Cell Lung Cancer

scientific article published on 25 May 2017

The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression

scientific article published in March 2018

The Role of Next-Generation Sequencing in Sarcomas: Evolution From Light Microscope to Molecular Microscope

scientific article published on 13 October 2017

The Ubiquitin Specific Protease USP18 Promotes Lipolysis, Fatty Acid Oxidation and Lung Cancer Growth

scientific article published on 30 December 2020

The glutaminase inhibitor CB-839 (Telaglenastat) enhances the anti-melanoma activity of T cell mediated immunotherapies

scientific article published on 23 December 2020

The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth

scientific article published on 16 December 2018

The potential role of platelets in the consensus molecular subtypes of colorectal cancer.

scientific article published on 6 July 2017

Towards precision oncology in RET-aberrant cancers

scientific article published on 20 March 2017

Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy

scientific article published on 29 July 2019

Unique Aberrations in Intimal Sarcoma Identified by Next-Generation Sequencing as Potential Therapy Targets

scientific article published on 31 August 2019

Validating Pharmacological Disruption of Protein–Protein Interactions by Acceptor Photobleaching FRET Imaging ⬇️

scientific article published on January 1, 2013

Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers

scientific article published on 21 October 2020

mTOR at the Transmitting and Receiving Ends in Tumor Immunity.

scientific article published on 27 March 2018

mTORC2 Promotes Tumorigenesis via Lipid Synthesis

scientific article published in December 2017

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