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List of works by Andrea Ilari

A Practical Approach to Protein Crystallography

scientific article

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

scientific article

A novel antimicrobial approach based on the inhibition of zinc uptake in Salmonella enterica.

scientific article published on 21 June 2017

Antioxidant Dps protein from the thermophilic cyanobacterium Thermosynechococcus elongatus

scientific article published on 3 October 2006

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells

scientific article published on 20 July 2017

Calcium- and pH-linked oligomerization of sorcin causing translocation from cytosol to membranes

scientific article published on 01 June 1997

Cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase from Thalictrum flavum.

scientific article

Crystal structure and ligand binding properties of the truncated hemoglobin from Geobacillus stearothermophilus

scientific article published on 30 October 2006

Crystalization and preliminary X-ray crystallographic analysis of the laminarinase endo-beta-1,3-glucanase from Pyrococcus furiosus

scientific article published in December 2004

Crystallization and preliminary X-ray crystallographic analysis of the unusual ferritin from Listeria innocua

scientific article published on 01 February 1999

Effect of the vinyl-globin interactions on the temperature-dependent broadening of the Soret spectra: a study with horse myoglobin and Scapharca dimeric hemoglobin reconstituted with unnatural 2,4-heme derivatives

scientific article published on 01 April 1997

Engineered ferritin for lanthanide binding

scientific article published in PLoS ONE

Escherichia coli flavohemoglobin is an efficient alkylhydroperoxide reductase ⬇️

scientific article published on 27 March 2003

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage.

scientific article published on 21 February 2018

Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

scientific article published on 10 April 2017

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

scientific article published on 26 November 2018

Identification and characterization of the pyridoxal 5’-phosphate allosteric site in Escherichia coli pyridoxine 5’-phosphate oxidase

scientific article published in 2021

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

article published in 2018

Information transfer in the penta-EF-hand protein sorcin does not operate via the canonical structural/functional pairing. A study with site-specific mutants

scientific article published on 23 April 2003

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography

scientific article

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

scientific article published in December 2017

Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation

scientific article

Iron and hydrogen peroxide detoxification properties of DNA-binding protein from starved cells. A ferritin-like DNA-binding protein of Escherichia coli.

scientific article

Iron incorporation into Escherichia coli Dps gives rise to a ferritin-like microcrystalline core

scientific article published on 5 August 2002

Kineococcus radiotolerans Dps forms a heteronuclear Mn-Fe ferroxidase center that may explain the Mn-dependent protection against oxidative stress

scientific article

Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase

scientific article published on 29 May 2015

Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases

scientific article published on January 2018

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes

scientific article published on 23 August 2013

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions

scientific article

Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins

scientific article published in May 2017

Plasticity of secondary structure in the N-terminal region of beta-dystroglycan

scientific article published on 01 March 2001

Polyamine-trypanothione pathway: an update.

scientific article published on 13 December 2016

Rigidity of the heme pocket in the cooperative Scapharca hemoglobin homodimer and relation to the direct communication between hemes

scientific article published on 01 January 1995

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

scientific article published on 06 April 2020

Salmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporter

scientific article

Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis

scientific article (publication date: 2014)

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.

scientific article published on 05 September 2014

Structural basis of Sorcin-mediated calcium-dependent signal transduction

scientific article published on 18 November 2015

Structural basis of enzymatic (S)-norcoclaurine biosynthesis

scientific article

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.

scientific article published on 24 April 2017

Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.

scientific article published on October 2013

Structural studies on flavohemoglobins

scientific article published in January 2008

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

scientific article published on 7 May 2015

Structure-function relationships in sorcin, a member of the penta EF-hand family. Interaction of sorcin fragments with the ryanodine receptor and an Escherichia coli model system

scientific article published on 01 February 2000

Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism

scientific article published on 29 April 2019

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

scientific article published on 21 April 2020

The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway ⬇️

scientific article published on August 21, 2012

The Salmonella enterica ZinT structure, zinc affinity and interaction with the high-affinity uptake protein ZnuA provide insight into the management of periplasmic zinc

scientific article

The X-ray structure of ferric Escherichia coli flavohemoglobin reveals an unexpected geometry of the distal heme pocket

scientific article

The X-ray structure of the zinc transporter ZnuA from Salmonella enterica discloses a unique triad of zinc-coordinating histidines

scientific article

The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference

scientific article

The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures

scientific article

The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length protein

scientific article

The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site

scientific article

The mutations Lys 114 --> Gln and Asp 126 --> Asn disrupt an intersubunit salt bridge and convert Listeria innocua Dps into its natural mutant Listeria monocytogenes Dps. Effects on protein stability at Low pH

scientific article

The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme.

scientific article published on 11 July 2018

The structure of maize polyamine oxidase K300M mutant in complex with the natural substrates provides a snapshot of the catalytic mechanism of polyamine oxidation

scientific article published on 25 January 2011

The truncated oxygen-avid hemoglobin from Bacillus subtilis: X-ray structure and ligand binding properties

scientific article published on 7 December 2004

The unusual dodecameric ferritin from Listeria innocua dissociates below pH 2.0.

scientific article published on 01 September 2000

The unusual intersubunit ferroxidase center of Listeria innocua Dps is required for hydrogen peroxide detoxification but not for iron uptake. A study with site-specific mutants

scientific article published in April 2005

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors

scientific article published on 27 June 2018

Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis

scientific article

Two different crystal forms of sorcin, a penta-EF-hand Ca2+-binding protein

scientific article published on 25 May 2001

Unusual affinity of cyanide for ferrous and ferric Scapharca inaequivalvis homodimeric hemoglobin. Equilibria and kinetics of the reaction

scientific article published on 01 June 1996

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