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List of works by Wei-Shuo Fang

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

scientific article published on 23 January 2018

A new triglucosylated naphthalene glycoside from Aloe vera L.

scientific article published on 26 July 2009

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization

scientific article published on 25 November 2015

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro.

scientific article published on 11 August 2013

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.

scientific article

An efficient semi-synthesis and structure revision of a cytotoxic triterpenoid 25-acetoxy-3alpha-hydroxyolean-12-en-28-oic acid from Liquidamber styraciflua

scientific article

An efficient semi-synthesis of 1-hydroxyl oleanolic acid analogs

scientific article published on 09 April 2017

Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck.

scientific article published on 25 March 2009

Anti-tumor activity of a 3-oxo derivative of oleanolic acid

scientific article

BACE inhibitory flavanones from Balanophora involucrata Hook. f

scientific article published on 14 August 2012

BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis

scientific article published in April 2008

BACE1 (beta-secretase) inhibitory phenolic acids and a novel sesquiterpenoid from Homalomena occulta

scientific article published in April 2010

Biotransformation of 3-oxo-oleanolic acid by Absidia glauca

scientific article published on 14 June 2010

Design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives.

scientific article published on 8 June 2011

Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods.

scientific article published on 26 April 2017

Distribution of paclitaxel and its congeners in Taxus mairei

scientific article published in November 2001

Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.

scientific article

Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.

scientific article published on 16 November 2012

High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

scientific article published on 12 August 2015

Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative

scientific article published in March 2017

Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation

scientific article published in January 2012

Jacaranone analogs from Senecio scandens

scientific article published in January 2009

Jacaranone glycosides from Senecio scandens

scientific article published on 01 January 2006

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

scientific article published on 07 July 2016

Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo.

scientific article

Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo.

scientific article published on January 2012

Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer.

scientific article

Microtubule stabilising agents for cancer chemotherapy.

scientific article published on May 2009

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.

scientific article published on 3 June 2017

Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes ⬇️

scientific article published on December 20, 2011

Natural products

scientific article published on 01 January 2009

New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis

scientific article published in January 2012

On the chemical constituents of Dipsacus asper. ⬇️

scientific article

Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.

scientific article

Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.

scientific article published on May 2007

Preparation, pharmacokinetics, biodistribution, antitumor efficacy and safety of Lx2-32c-containing liposome

scientific article

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses

scientific article published in March 2010

Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups

scientific article published on 09 December 2015

Structural studies of taxol analogues for drug discovery.

scientific article published on September 2008

Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates

scientific article published on 2 May 2016

Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids

scientific article published on 08 June 2019

Synthesis and biological activities of high affinity taxane-based fluorescent probes

scientific article published on 10 December 2008

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

scientific article

Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

scientific article

Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues

scientific article published on 14 March 2007

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

scientific article

Three new antioxidant C-glucosylanthrones from Aloe nobilis

scientific article published in June 2010

Two novel tetrairidoid glucosides from Dipsacus asper

scientific article published on 01 May 2006

[Chemical constituents from Sambucus chinensis]

scientific article published on 01 May 2012

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